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Misc Methylphenidate-induced topical anesthesia: mechanism of action?

k-opioid

Bluelighter
Joined
Aug 2, 2008
Messages
118
Location
Minneapolis/Pittsburgh (uni)
I've recently discovered that the sublingual administration of methylphenidate induces a numbness that is not unlike that of cocaine--albeit much less potent.
Cocaine and methylphenidate have many pharmacological similarities, acting both are norepinephrine-dopamine reuptake inhibitors. However, their chemical structures seem very different.

I know that cocaine induces numbness by blocking the voltage-gated sodium channels in nerve cells, but I have not found any literature suggesting methylphenidate's mechanism of action as an anesthetic agent. In fact, no one seems to acknowledge methyphenidate's numbing properties--has anyone else actually noticed this??
 
I go for the above, perhaps accompanied with D2-receptor mediated analgesia.

Though technically, it's noradrenergic activity that causes the vasoconstriction.
 
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