k-opioid
Bluelighter
I've recently discovered that the sublingual administration of methylphenidate induces a numbness that is not unlike that of cocaine--albeit much less potent.
Cocaine and methylphenidate have many pharmacological similarities, acting both are norepinephrine-dopamine reuptake inhibitors. However, their chemical structures seem very different.
I know that cocaine induces numbness by blocking the voltage-gated sodium channels in nerve cells, but I have not found any literature suggesting methylphenidate's mechanism of action as an anesthetic agent. In fact, no one seems to acknowledge methyphenidate's numbing properties--has anyone else actually noticed this??
Cocaine and methylphenidate have many pharmacological similarities, acting both are norepinephrine-dopamine reuptake inhibitors. However, their chemical structures seem very different.
I know that cocaine induces numbness by blocking the voltage-gated sodium channels in nerve cells, but I have not found any literature suggesting methylphenidate's mechanism of action as an anesthetic agent. In fact, no one seems to acknowledge methyphenidate's numbing properties--has anyone else actually noticed this??