Methyl-K has popped up. Predictions on effects?

[SuperPsych]

Methyl-K has become available. It's a chemical synthesized by Alexander Shulgin and described in Pihkal. The description in Pikhal makes it seem not very worthwhile, but my guess is that they never found the proper dose as the highest they tested was 100mg. Methyl-J sounds pretty nice so my hope would be that this has some worthwhile activity. I don't plan on getting any, I just saw it pop up and the name caught my attention and got me interested in it as I have never heard of it until now.

From Wikipedia:
"N-Methyl-1,3-benzodioxolylpentanamine (MBDP; Methyl-K, UWA-091), also known as 3,4-methylenedioxy-α-propyl-N-methylphenethylamine, is a psychoactive drug of the phenethylamine chemical class. It is the N-methyl analogue of 1,3-benzodioxolylpentanamine (BDP; K). Methyl-K was first synthesized by Alexander Shulgin ("Sasha" Shulgin). In his book PiHKAL ("Phenethylamines i Have Known And Loved"), the minimum dosage is listed as 100 mg, and the duration is unknown. Very little is known about the pharmacology, pharmacokinetics, effects, and toxicity of Methyl-K."

From Pihkal:
"QUALITATIVE COMMENTS: (with 100 mg) There were no effects. I was busy and totally wound up and didn't sleep until 3 AM, but this was probably unrelated to the Me-K."

That is the only entry in Pihkal. I'm curious as to if that was a threshold dose and if a dose like 250mg might result in a proper and worthwhile experience. I'm curious if anyone has any thoughts or predictions. The temptation to get some and guinea pig is definitely there. It's been 10 years or more since I was one of the first to try a new substance. There's a certain thrill in exploring the unknown.

 

[3DQSAR]

One on one hand the report says it had no effect and then goes on to say the taster went on to feel 'wound up' all day and not being able to sleep until 3AM.

That's not QUITE the placebo effect, but it's an example of someone not finding the expected effects (entactogenic I presume) and ignoring what the stuff was actually doing.

It's a DRI - possibly one that hasn't got much oral bioavailability.

 

[SuperPsych]

One on one hand the report says it had no effect and then goes on to say the taster went on to feel 'wound up' all day and not being able to sleep until 3AM.

That's not QUITE the placebo effect, but it's an example of someone not finding the expected effects (entactogenic I presume) and ignoring what the stuff was actually doing.

It's a DRI - possibly one that hasn't got much oral bioavailability.

That's what I was thinking. Being 'wound up' and kept up until 3am definitely sounds like it had some activity going on. Is it known to be a DRI or is that just a prediction. I haven't been able to find any solid answers into exactly what it does. Would be interesting to see some reports on it effects insufflated, rectally, or smoked. It popped up in the last week or so, so I'm sure reports will be popping up on reddit soon.

 

[3DQSAR]

Prolintane is the closest medicine and that is described as a 'mild stimulant'.

Pyrovalerone is a prolintane derivative and MDPV is actually mentioned in the pyrovalerone patent,* so it seems very likely that the 3,4-MD will likewise increase activity.

But the optimal chain length is 5. Yes, those with 6 were active, just less so.

I bet the dimethyl amine derivative is more potent.

*In the case of MDPV, my belief is that the p-Me was chosen instead partly due to cost but more importantly, because that p-Me acts as a sacrificial moiety. The body can easily oxidize that methyl with non-specific blood enzymes thus the metabolic fate is much easier to determine and it's most unlikely that there won't be some genetic trait that results in metabolism leading to anything potentially toxic.

 

[Esperighanto]

This is just the non-beta keto version of the old pentylone, it seems to be unpopular based on what reports I've seen but maybe it has potential in the right mix, or a certain set & setting.

 

[3DQSAR]

This is just the non-beta keto version of the old pentylone, it seems to be unpopular based on what reports I've seen but maybe it has potential in the right mix, or a certain set & setting.

Prolintane is less potent that analogues with a benzylic ketone (or bioisostere) but it's still pretty active. I'm not a stimulant user but am aware that those analogues with said ketone do appear to produce more compulsive redosing. I suspect it's at least in part due to the much faster onset.

 

[Esperighanto]

Prolintane is less potent that analogues with a benzylic ketone (or bioisostere) but it's still pretty active. I'm not a stimulant user but am aware that those analogues with said ketone do appear to produce more compulsive redosing. I suspect it's at least in part due to the much faster onset.

I find it interesting that the more flat/stimulant-y cathinones are quicker to come up and leave, whereas beta-keto-2C-B (and I'm assuming other bk-2C-X's) is often reported as having a pretty long come-up time and being gentler on redose urges.