Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,264
In an article by the Daily Mail titled ' why crystal meth ravages the body' scientists claim they have found out why methamphetamine addicts age so quickly. They point out that methamphetamine induced disturbances of lipid metabolism in cells throughout the body triggers the release of highly toxic substances called ceramides. They described these as toxic proteins, but according to my knowledge ceramides are lipid amides but please correct me if I'm wrong. Never the less ceramides are extremely toxic went over expressed in cells and are powerful promoters of programmed cell death. I don't think ceramides are necessarily a bad thing since in small amounts they increase the metabolic activity of cells, but in the large amounts released by methamphetamine exposure they are lethal to cells.
The article focuses on the role of ceramides in methamphetamine induced accelerated ageing, but I am more interested in where the proposed mechanism fits in with methamphetamine and regular amphetamine neurotoxicity. The article also states that scientists using an enzyme inhibitor that prevents the release of ceramides have been able to prevent the harmful effects of methamphetamine on rodents. The inhibitor is also being modified and studied as a possible treatment for human methamphetamine dependence or at least preventative against its toxicity.
What do you all think?
Should we be optimistic or could this be too good to be true?
Is it possible that a ceramide release inhibitor when taken with methamphetamine could allow users to enjoy the high without toxicity or do you think it's will interfere with and suppress the pleasurable aspects.
The article focuses on the role of ceramides in methamphetamine induced accelerated ageing, but I am more interested in where the proposed mechanism fits in with methamphetamine and regular amphetamine neurotoxicity. The article also states that scientists using an enzyme inhibitor that prevents the release of ceramides have been able to prevent the harmful effects of methamphetamine on rodents. The inhibitor is also being modified and studied as a possible treatment for human methamphetamine dependence or at least preventative against its toxicity.
What do you all think?
Should we be optimistic or could this be too good to be true?
Is it possible that a ceramide release inhibitor when taken with methamphetamine could allow users to enjoy the high without toxicity or do you think it's will interfere with and suppress the pleasurable aspects.