socio
Bluelighter
- Joined
- Dec 14, 2009
- Messages
- 342
This poster's opinion is that Methadone blocks the subjective effects of Tianeptine, at least in large part (after dosing for the day). Yet tianeptine is effective for pre-dosing / morning and "missed-dose" "break-through withdrawal" symptoms on methadone maintained patients.
Using tianeptine while on methadone...how much of the opioid effects does one typically experience when dosing regularly? When is it able to "break through" and when is it "blocked" completely?
I think a lot of people will agree that tianeptine has strong opioid activity, especially those who've both used long term opioids and tianeptine (whether orally in the 100s of mg's -- not likely to be safe for those without tolerance -- or IV, which has serious negative drawbacks even when using the straight powder rather than crushed tablets), or used tianeptine to compensate for withdrawal from suboxone, methadone, herion, etc. when missing a day's dose or prior to dosing for that day. E.g., keeping a few mg around if you're on a maintenance drug is wise in case you lose a dose. This works well enough in most reported experiences.
Combining tianeptine in high doses alongside maintenance opioids, such as methadone (to get oneself feeling well enough to get to the clinic in the AM or motivated work later in the PM), and then stopping abruptly, can absolutely result in irritating-to-debilitating withdrawal that lasts ~2-4 days.
Since most reports of opioid users substituting or supplementing with tianeptine at times when they are out of their regular dose, or as far in the daily cycle from it as possible, I wonder how much of it is blocked by, say an average dose of methadone, 50-100mgs, or 4-16mgs suboxone? I wouldn't guess any competition with other "non-blocking" opioids.
Opinions?
Using tianeptine while on methadone...how much of the opioid effects does one typically experience when dosing regularly? When is it able to "break through" and when is it "blocked" completely?
I think a lot of people will agree that tianeptine has strong opioid activity, especially those who've both used long term opioids and tianeptine (whether orally in the 100s of mg's -- not likely to be safe for those without tolerance -- or IV, which has serious negative drawbacks even when using the straight powder rather than crushed tablets), or used tianeptine to compensate for withdrawal from suboxone, methadone, herion, etc. when missing a day's dose or prior to dosing for that day. E.g., keeping a few mg around if you're on a maintenance drug is wise in case you lose a dose. This works well enough in most reported experiences.
Combining tianeptine in high doses alongside maintenance opioids, such as methadone (to get oneself feeling well enough to get to the clinic in the AM or motivated work later in the PM), and then stopping abruptly, can absolutely result in irritating-to-debilitating withdrawal that lasts ~2-4 days.
Since most reports of opioid users substituting or supplementing with tianeptine at times when they are out of their regular dose, or as far in the daily cycle from it as possible, I wonder how much of it is blocked by, say an average dose of methadone, 50-100mgs, or 4-16mgs suboxone? I wouldn't guess any competition with other "non-blocking" opioids.
Opinions?
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