Opioids Methadone for pseudoindoxyl withdrawal?

[aspiringchemist]

Long story short, I have been on 16mg suboxone for 4 years and in the last year I’ve walked myself down to 0.25mg (1/4mg) per day.

I also developed a nasty pseudoindoxyl habit of 150-300mg/day. I don’t find suboxone helpful in the least with the withdrawal. Has anyone used methadone to come off 7OH and pseudo?

What were your doses like and schedule? Let’s say you had 200mg methadone to taper with and needed to make a plan. Thanks!

 

[slightly_paranoid]

I had a 7-OH habit (around 100mg a day) and Suboxone stopped the withdrawal for me at 16mg a day. I am wishing that I would have asked for Methadone and is something I plan on bringing up in my next appointment with my Addiction Specialist Doctor as I have legit chronic pain that Methadone's NMDA antagonism is supposed to help. However, Suboxone is much better than nothing and will work for most that are serious about quitting 7-OH. If I am not in emotional pain, then I am in physical pain on the bad days. But most days are good and am grateful for what I have.

 

[4DQSAR]

https://www.jpsmjournal.com/article/S0885-3924(21)00366-3/fulltext

I don't know too much about the various actives in kratom and it was only a couple of weeks ago that someone pointed me at some semi-synthetic MGM-15 and MGM-16, the latter being so potent that I suggest unless specifially screened for, would not be detected in kratom containing products.

I know it took the DEA over two years to incorrectly identify the designer homologue of fentanyl as 3-methyl fentanyl (it was actually alpha methyl fentanyl).

So who knows what is in these products? I honestly don't know as we don't have them in the UK but Grisham's Law would dictate that IF MGM-16 offers more profit, someone will add MGM-16 (as long as they only supply it as a herbal product).

 

[red22]

MGM-15 and MGM-16

Someone should start a topic for these.

 

[PenguinWithNapalm]

Someone should start a topic for these.

Yeah fr. I literally just learned about them from this post.

 

[4DQSAR]

I think it important to note that both of the compounds I mentioned appear to be 'duelists' with their analgesic activity deriving from both MOR and DOR activity. It's mportant to recognize that a compound denonstrating analgesic activity in an animal model isn't a good guide to the subjective activity in man. From what I have read, MGM-15 may already have turned up in samples of kratom but I don't think the latter far more potent (in terms of analgesia) MGM-16 has turned up yet.

I have seen other examples of RCs that were produced on the basis of their demonstrating extreme potency as analgesic in animal models only for it to arrive on the market and people find the subjective experience quite unpleasent. In that case I believe the compound had a lot of KOR activity - dysphoria being a common problem with KOR ligands. But obviously a tail-withdrawal test in a mouse isn't going to provide qualitative information.

So while I think it's important to know these compounds exist, don't look at an animal study and assume it will be euporic. What is euphoric can only really be tested in man and then, mice are not always good models of potency so CAREFUL testing is required. Just offering it for sale isn't what I would consider careful.