Benzos Mephenesine

[Like dead]

Hello everyone, im very sory if this is in the wrong section, but I dont know as what this drug is classified and scince its a depressant with similar effects... anyway, on my trip to France I bought a very interesting drug (sold as a muscle relaxent under the name decontractyl). I would like to know what exactly it is and if anyone has any experience with it (eg alternative administration routes to oral, BA, drug interactions, effects on CNS etc). I have searched everywhere on the net and cant find much info.

 

[TheAzo]

Might get better responses over in ADD - they tend to know more about obscure wierdass drugs most people have never heard of.

 

[mahatmaganja420]

According to wiki it's actually Mephensin and "Mephenesin is a centrally acting muscle relaxant. It can be used as an Antidote for Strychnine poisoning." Other than that I found that the "Decontractyl" usually has 500 mg per coated pill, which appears to be the only form I can find. "RESERVED ADULT (over 15 years)
Oral. Swallowed with a little water. 1-2 tablets 3 times a day (3-6 tablets per day)"
then
"This medication is counter-indicated if:
- Hypersensitivity to any component.
- Porphyria.
RECOMMENDED:
This medication is generally not recommended during pregnancy or breastfeeding:
- Pregnancy: there is no reliable data on teratogenesis in animals. There is currently no relevant data, or insufficient numbers to evaluate a possible effect of malformation or mephenesin fetotoxic when administered during pregnancy. Consequently, the use of this drug is not recommended during pregnancy.
- Breastfeeding: in the absence of data, the use of this drug is not recommended during breastfeeding. "
and...
" - Exceptionally, cases of anaphylactic shock have been reported.
- Rare cases of drowsiness, nausea, vomiting, allergic reactions to s type of rash."
That's about all I can find without doing some serious research. What sort of information were you looking for? Personal experience reports?

 

[debaser]

I have some mephenesin pills too, Decontractyl (OTC in France). There's a ointment form too, same name. It's ok the first few times you try it, but the novelty fades quickly. Very short half-life too, one and a half hour max. Weak drug IMO. Oh and it's very far from the efficiency of benzos.

 

[Like dead]

thanks for researching and replying, but i already knew that (dont get me wrong im not trying to sound like an ass, it can come accross that way sometimes). I research my stuff as much as I can. It has very interesting effects (even at the recomended dose which is one gram), but its VERY random (one day, bam im noddin, the next nothin at all). But as I said before I cant find any Info apart from dosage and its uses (which is strange as it is an OTC drug in france). The only other information is a case were a woman died from an overdose (15 grams or so) and tests on rats. If anyone knows about this drugs availability in other countries (australia, germany etc) that would be helpfull too. I cant find any specific info or experiences, which is specifically what im interested in. Its not even on erowid. thanks again for the reply.

 

[Like dead]

oh yes and to loulu reed (didnt mean to ignore you), i personaly dont have much experience with benzo's more with opiates, but as far as the effects are concerned, i thought it was quite similar. But i completely agree with you, too short and not very effective after the first few tries. Do you know how long I need to wait till it works well again? I brought a bunch of mephenesine (along with other things, love your OTC policies) and I took a break for to days and took five today, I feel realy bad because I couldnt resist the temptation and they did nothing . Also does the ointment give you the same effects? As in duration if at all? is it even absorbed efficiently enough through the skin to feel it?

 

[debaser]

I have a box I never finished... but i don't know how it works, really, I'm no expert. I would say the ointment is useless for recreational purposes, but I never bought some. If I have some muscle problems I'll definitely give it a try, though. Strange drug.

 

[mahatmaganja420]

I found something that said it was ... "Once used in association with pentobarbital for anesthesia, but no longer used because of its many side-effects, including venous thrombosis and hemolysis." So... That's off-putting. I also found a PDF on the topic which I had to hand copy this information from... "Mephenesin is a muscle relaxant which acts mainly on the spinal cord but which also has a definite effect on the thalamus, the basal ganglia, and the brain stem. It relaxes hypertonic muscles, without appreciably reducing motor power, and allays fear and tension.
A number of investigators have reported that the drug is effective by the oral route in disorders associated with skeletal muscle spasm. ... Laurence (1952) found that is spastic paralysis, oral administration produced benefit in only two out of 27 cases, but good results have been reported in treatment of spasticity of multiple sclerosis. Mephenesin has also been used successfully in the control of tetanus convulsions, alcoholism, anxiety states, premenstrual tension, and other spastic and hyperkinetic conditions.
The main disadvantages of Mephenesin are its brevity of action and the relatively large doses required to secure a satisfactory response. Animal experiments have indicated that a new derivative Mephenesin carbamate, may largely overcome these disadvantages...

... A PHARMACOLOGICAL NOTE ON MEPHENESIN AND MEPHENESIN CARBAMATE
Mephenesin is absorbed readily from the gastro-intestinal tract and it is conjugated and excreted rapidly. Clinical efficacy is therefore dependant on the administration of adequate doses at regular intervals. It is now generally agreed that the average dosage for an adult is one to three grammes, given four or five times daily. The toxicity of the drug by the oral route is very low, but mild nausea and transient vertigo may occur, especially is the Mephenesin is taken on an empty stomach. In order to minimize these side-effects, it is recommended that "Tolserol" treatment should be commenced with one gramme administered four times daily after meals or after taking a draught of milk or other liquid, and that this dose should be gradually increased until a satisfactory response is obtained."
So... According to that your dose should actually be somewhere from 2 - 6 of those pills to START with assuming you're an adult... Also, the fact that it is rapidly absorbed and excreted would explain why the effects may quickly deteriorate. Finally, as this article states that it has potential benefit of use with alcoholics, this leads me to potentially believe (But not necessarily claim) that this MAY have effect on GABA receptors in the brain (Stating that it may help with "anxiety states" also makes this seem plausible) I can understand how it may give some effects similar to a Benzo or opiate. However, since it's OTC and very little information is available on it... I think it'd probably be best not to try and mess around with it very much for now. If it's new there is no reason to be a guinea pig, if it's old and it's uncommon or little information exists about it, there's PROBABLY A REASON. I think you're better off buying some OTC opiates or Benzos if that's the effect you want. At least they have VOLUMES of information widely available on each, as well as a LONG record of use. Also, when taking one of those two types of drugs you know that you aren't going to try to use for a 2nd or 3rd day in a row and disappointingly get no effects...

 

[debaser]

It's a propanediol derivative, as are carisoprodol (Soma) and meprobamate. However, these two drugs are far superior.

 

[Like dead]

thanks for that info gandi, the recomended dose on the box is 1 to 2 pills, and is anyway only recomended for people above the age of 15. I read the part about mephenesine's use in anaesthesia in conjuction with phenobarbitol, but the rest of the info is new to me (where'd u find it, I looked quite a while on the net). Since its effects were related to how much I ate, I guessed the rapid excretion part, still good to hear its esearched : ). I will be carefull (as I am with all things) but I have got to test a couple more things. To me this substance has a very distinct feeling. Also, I wished I could use opiates days on end but I need to study too : ( anyway does anyone know if this substance is physically addictive? And if its available anywhere else?

 

[Like dead]

have you tried carisoprodol? been interested in that but cant get my hands on it, is it commonly prescribed?

 

[mahatmaganja420]

If it affects the GABA receptors in a way similar to alcohol or Benzos then there is a fairly reasonable change that it could be addicting. However since you say it's difficult to get effects past the first day or so, I don't see how that'd become an issue. I wouldn't recommend taking opiates daily either, so don't think that's what I was saying as an alternative. You shouldn't be taking ANY drugs every day unless you're being prescribed them by a doctor and you have discussed and researched everything thoroughly, etc. Yes I have tried Carisoprodol (Soma) and it's a quality muscle relaxer. It is definitely one of the most effective and sought after muscle relaxers. It was once OVERLY easy to obtain due to it being available OTC in many spots (Like Mexico) and the fact that it wasn't even specifically scheduled in the US (It was still prescription only, it just didn't receive a certain scheduling number.) These days though, many people are starting to catch on to its popularity and the amount being prescribed has dropped a fair bit. Since you seem to be able to shop in countries other than the US it's possible you might be able to find it OTC somewhere. OR you could EASILY order it online from one of the many THOUSANDS of online pharmacies that sell the drug.

 

[xxl]

I once had a blockage of some back muscles, a so-called "stiff neck". I could't move an inch without feeling excrutiating pain. I took some "Décontractyl" (the above-mentioned French product). It didn't get better so a taxi was called and I went to the clinic for urgent treatment. The first thing the doc told me was that "Décontractyl" was rubbish as a treatment. He gave me an immediate injection of diazepam and that worked. I would say this is a molecule without much value. Recreational value = 0. Therapeutic value = 1 (out of ten)?

 

[Like dead]

gandi, I was joking with the daily remark, I have quite a bit of knowledge concerning the addictive potential of opiods. I am rather skeptical of online pharmacies, have you ever ordered anything from one? also do you know if carisoprodol is available "under the counter" (from pharmacies without a prescribtion mainly in poor areas, like tramadol in france)?

 

[Like dead]

And XXL, crank up the dose a bit, Im sure you will find this substance quite interesting, it peaks quickly and can feel VERY intense (the first time). As for theraputic value, I think it only works in relieving minor aliments, such as a sore back or tensed muscles after exercise.

 

[mu.]

I tested it but not found recreational aspect