hussness
Bluelighter
I was just glancing through a few journal articles and noticed that some research has been done recently on meperidine analogs as far as binding to DAT, NET, and SERT. A couple of references are below:
J. Med. Chem. 2005, 48, 1336-1343.
J. Org. Chem. 1998, 63, 418-419.
Anyway, I've posted the structures of nocaine, meperidine, and a compound that I don't think has been studied that I was playing around with in chemdraw. I was wondering if it would be theoretically possible to get a compound that was an H-bond donor in the all of the right places such that it would bind with high affinity to DAT, and also to NET, SERT, and have affinity for the mu opioid receptor -- I guess sort of a theoretical speedball all wrapped up into one compound?
J. Med. Chem. 2005, 48, 1336-1343.
J. Org. Chem. 1998, 63, 418-419.
Anyway, I've posted the structures of nocaine, meperidine, and a compound that I don't think has been studied that I was playing around with in chemdraw. I was wondering if it would be theoretically possible to get a compound that was an H-bond donor in the all of the right places such that it would bind with high affinity to DAT, and also to NET, SERT, and have affinity for the mu opioid receptor -- I guess sort of a theoretical speedball all wrapped up into one compound?
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