Greetings to all. I take memantine daily - 20 to 60 mg at the moment. Lately I've been trying not to exceed 40mg (20mg in the morning and afternoon) orally for many reasons. I have a lot of misconceptions and misunderstandings, I will try to describe them as detailed and accessible as possible, while not forgetting anything. I'll just describe the situation from my side, and you, please, add what you think is necessary
Memantine has changed my life. No, really. It "pulled me out of the matrix/system", gave me an immediate connection with the world, like after a psychedelic trip. I understand everything much deeper, my thinking is more organized, as if I have hacked into a biofield and can draw any information from there
ADHD, dysthymia, and the effects of amphetamines in terms of psychological cravings and neurotoxicity - I no longer feel, like I've been reborn. I fully understand that this is just a game of neurotransmitters and all that, but there is a feeling that I understand and know absolutely everything, as if I stand on the verge between understanding absolute / objectivism and relative / subjectivism
The largest dosage I took per day was 100 mg in divided doses. Several ROAs were tested, here are the impressions. By the way, this applies to some extent to absolutely all substances, including even magnesium or creatine, with which I also experimented. This should be taken as a hypothesis based on scientific data / subjective impressions and nothing more.
• Oral: most mild, smooth, gradual, euphoric, controlled, human, soothing. This may be partly due to the large number of serotonin receptors in the gut.
• Intranasal. Fewer side effects from the periphery (probably the nose-to-brain pathway is involved). It has an unbalanced effect on the brain, some parts of the brain receive more of the drug, some less. The ventral tegmental area(VTA) in particular is hit the hardest - this may partly explain the "cocaine-like" nature of intranasal use - overconfidence, tunnel vision, uncontrollable mania, nervousness, etc.
3. Buccal - has a similar or greater AUC than oral due to passive diffusion, but bypasses first pass metabolism and is a parenteral route of administration. I would compare it to an intravenous drip over a period of time. Perhaps it has a higher percentage of substances entering the brain / fewer peripheral side effects due to direct transport to the central nervous system (the trigeminal nerve, which transports substances directly to the central nervous system, innervates throughout the mucous membrane, including the cheek)
4. Sublingual. Something between intravenous, intranasal and oral - the action starts instantly; peak concentrations are reached only after some time, part of the drug is metabolized, because part is swallowed and only ~ 2/3 of the substance bypasses the first pass metabolism; similarly to the nasal one, it is absorbed through the mucous membrane and also part of the drug directly enters the brain, because the trigeminal nerve also innervates the sublingual region.
Comparing intranasal, buccal and sublingual, it can be assumed that the more the drug enters the brain, the less it reaches the plasma / rest of the body and, therefore, has fewer peripheral side effects.
In this respect, the gradation is Intranasal>Buccal>Sublingual
There is a little brain fog at the beginning of the course. It is not critical, but during this period you can do insignificant nonsense and be subjected to many misconceptions. It is caused by antagonism of acetylcholine nicotinic receptors. Subsequently, tolerance is developed to this side effect. By the way, this paragraph applies to all substances - for example, marijuana will not stupefy, and due to non-competitive NMDA antagonism, the brain will not become too addicted - tollers / psychological cravings will not be formed. Again, this point applies to all substances, not just grass.
As for the pharmacology of memantine, it is as favorable as possible, it should be taken as:
1. The most effective form of magnesium for the brain - non-competitive NMDA antagonism
2. The purest dopamine euphoria and stimulation is the agonism of dopamine receptors of the second subtype D2, which are responsible for almost the majority of the desired effects of stimulants (there will be no magic without this). And all this without norepinephrine nervousness
3. Microdosing of psychedelics - 5ht3 receptor antagonism. It is the best therapeutic/recreational remedy.
An ideal dissociative for every day, it is an excellent complement to all substances due to the prevention of tolerance / addiction / neurotoxicity.
Maybe later I'll add something else, for now that's it.
Memantine has changed my life. No, really. It "pulled me out of the matrix/system", gave me an immediate connection with the world, like after a psychedelic trip. I understand everything much deeper, my thinking is more organized, as if I have hacked into a biofield and can draw any information from there
ADHD, dysthymia, and the effects of amphetamines in terms of psychological cravings and neurotoxicity - I no longer feel, like I've been reborn. I fully understand that this is just a game of neurotransmitters and all that, but there is a feeling that I understand and know absolutely everything, as if I stand on the verge between understanding absolute / objectivism and relative / subjectivism
The largest dosage I took per day was 100 mg in divided doses. Several ROAs were tested, here are the impressions. By the way, this applies to some extent to absolutely all substances, including even magnesium or creatine, with which I also experimented. This should be taken as a hypothesis based on scientific data / subjective impressions and nothing more.
• Oral: most mild, smooth, gradual, euphoric, controlled, human, soothing. This may be partly due to the large number of serotonin receptors in the gut.
• Intranasal. Fewer side effects from the periphery (probably the nose-to-brain pathway is involved). It has an unbalanced effect on the brain, some parts of the brain receive more of the drug, some less. The ventral tegmental area(VTA) in particular is hit the hardest - this may partly explain the "cocaine-like" nature of intranasal use - overconfidence, tunnel vision, uncontrollable mania, nervousness, etc.
3. Buccal - has a similar or greater AUC than oral due to passive diffusion, but bypasses first pass metabolism and is a parenteral route of administration. I would compare it to an intravenous drip over a period of time. Perhaps it has a higher percentage of substances entering the brain / fewer peripheral side effects due to direct transport to the central nervous system (the trigeminal nerve, which transports substances directly to the central nervous system, innervates throughout the mucous membrane, including the cheek)
4. Sublingual. Something between intravenous, intranasal and oral - the action starts instantly; peak concentrations are reached only after some time, part of the drug is metabolized, because part is swallowed and only ~ 2/3 of the substance bypasses the first pass metabolism; similarly to the nasal one, it is absorbed through the mucous membrane and also part of the drug directly enters the brain, because the trigeminal nerve also innervates the sublingual region.
Comparing intranasal, buccal and sublingual, it can be assumed that the more the drug enters the brain, the less it reaches the plasma / rest of the body and, therefore, has fewer peripheral side effects.
In this respect, the gradation is Intranasal>Buccal>Sublingual
There is a little brain fog at the beginning of the course. It is not critical, but during this period you can do insignificant nonsense and be subjected to many misconceptions. It is caused by antagonism of acetylcholine nicotinic receptors. Subsequently, tolerance is developed to this side effect. By the way, this paragraph applies to all substances - for example, marijuana will not stupefy, and due to non-competitive NMDA antagonism, the brain will not become too addicted - tollers / psychological cravings will not be formed. Again, this point applies to all substances, not just grass.
As for the pharmacology of memantine, it is as favorable as possible, it should be taken as:
1. The most effective form of magnesium for the brain - non-competitive NMDA antagonism
2. The purest dopamine euphoria and stimulation is the agonism of dopamine receptors of the second subtype D2, which are responsible for almost the majority of the desired effects of stimulants (there will be no magic without this). And all this without norepinephrine nervousness
3. Microdosing of psychedelics - 5ht3 receptor antagonism. It is the best therapeutic/recreational remedy.
An ideal dissociative for every day, it is an excellent complement to all substances due to the prevention of tolerance / addiction / neurotoxicity.
Maybe later I'll add something else, for now that's it.
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