MegaCombination Dosing

[Reminisant B]

I'm not sure if this has been suggested before, I might be stumbling upon an idea already told but...

Take ONE drug, find its threshold level dose, e.g 2C-I = 10mg. Divide that dose by 20 and combine in the same manor with another 19 drugs.

The general idea being any overall effect of the mix cannot be atrributed to any ONE drug as they are all well below threshold level. Instead only effects shared by all 20 drugs might show through. Of course this would include effects both unwanted (Side effects) and wanted effects.

Trying this with say 2C compounds I find a very intriguing thought. The other obvious one that comes to mind would be different benzo's.

It would be best to get a group of drugs as similar as possible to reduce complex interactions and reduce possible toxicity problems. For example MAOI's would not be a good choice. Also one would have to obtain 20 compounds and measure them out precisly(Different 1/20 of threshold doses) which would be dificult.

The idea is still intriguing me though. Purely hypothetical, as getting 20 different compounds of anything would proove near impossible or just expensive I guess.

Any opinions?

 

[Jamshyd]

The idea is still intriguing me though. Purely hypothetical, as getting 20 different compounds of anything would proove near impossible or just expensive I guess.

Actually this is not the biggest problem.

The biggest problem is that, especially in the case of the 2Cs, we know next to nothing about the health effects of each, let alone 20 combined.

This is a guess - I could be wrong, but I would imagine it would be quite an assault on MAO and you might end up with something ugly.

 

[Reminisant B]

^Agreed,

 

[Jamshyd]

To be fair, I have combined, if I remember the dose correctly, about 5mg 2CI and 8mg 2C-T-2 and it produced strong effects that felt like a third, totally different drug. On a shulgin scale it was a +++, whereas those doses separately would have been only threshold doses.

I also combined DPT and DiPT (actually posted a report in the TR forum just a couple of days ago) and I've combined low doses of DiPT with its 4-HO and 4-AcO substitutes, and found tryptamines blend much smoothly than phenehtylamines. But that could very well be subjective.

 

[mad_scientist]

I had 21 different drugs for my 21st, it was great fun. And made up mixes of 12 drugs, 15 drugs etc in drinks a few times. I'd point out i was in my last year of a pharmacology degree at the time so was pretty sure of which things were safe to mix and at which doses, and don't go doing this unless you have much prior experience with all compounds involved, including previously mixing them in 3s and 4s and 5s before you go up to bigger numbers.

Main thing is to make sure the dose of each drug is relatively small. Generally put like 1-3 doses of each one into a big bottle of juice, then share it between a big group of people over an extended period of time, just having small shots of juice at a time so the amount of each drug you're taking at once is tiny, but over time it builds up to a lovely mixed feeling.

Best mixture i made in terms of effects was methylone, MDMA, methylphenidate, caffiene, sibutramine, diazepam, alprazolam, nitrazepam, ketamine, methadone, 5MeODiPT, LSD, psilocybin, 1,4-butanediol, GBL, 5HTP & cialis, pretty much just one or two doses of each except methylone and ketamine which there was probably 5-10 doses worth, and it was shared between 12 people over perhaps an 8 hour period, so each person individually only had a very small dose of each drug.

Also carefully go through and work out any significant interactions that might occur, some drugs don't play nicely with others, i.e avoid ephedrine or DXM obviously, but also in my experience, 2CB, 2CI, piracetam, adrafinil, or any SSRIs don't make good ingredients for a mix as they tend to interfere with the actions of others. Avoid MAOIs, (including 2CT7, 2CT21 etc) and don't put too much strong uppers, strong downers or strong hallucinogens in the mix, the best ones have a pretty even balance effects wise, too much of one type of drug and thats all you feel so the effects of the others are wasted.

 

[johanneschimpo]

i'll mix threshold doses of every opiate i can find, that might be nice
I'll even add 2 darvocet!

 

[dubmachine]

i'll mix threshold doses of every opiate i can find, that might be nice
I'll even add 2 darvocet!

I used to do this all the time (it's possible that many poly drug users take the same approach.) I add just a threshold or even sub threshold dose of of what I want to feel like. If I'm on dex and opiates and weed and want things to go a little wacky, I'll throw in a pinch of shrooms. later if I want to chill I throw on a 1/2 or a 1/4 of a benzo. Some of it is creating a nice high, some of it is trying to avoid a comedown, some of it is offsetting unpleasant side effects of what I've already taken.

I do not advocate this at all, it's dangerous and irresponsible and toxic. I'm still in one piece and alive(for now ) partly because I've always been risk averse, so I've always underdosed and maintained a neurotic vigilance and awareness of my overall state.

Some call it the kitchen-sink garbage bin approach, I prefer to think of it as a "custom" or "boutique" high

 

[fastandbulbous]

Well with a reduced scope of choice, i've done this with various 2C- combinations in the past, mostly with 2C-B/2C-C/2C-D/2C-E/2C-I in 2 or 3 drug combinations at half/third their respective normal full activity dose for me. While any combination of 2C-B/C/I didn't produce anything of note (probably due to the similarity ie 4-halogen substituted), 2C-C & 2C-D was quite interesting in that it gave it a depth that was grater than you would normally get fro 2C-D alone (2C-C just isn't that deep unles administered via nasal/rectal/imjection administration or at silly/stupid oral doses), almost being 'son of 2C-E', but with a reduced body load. I founf 2C-E + 2C-I to have an uncomfortable push and can't say I recommend it although using 2C-E with 2C-C, which is almost sedating by comparison might be worth the effort.

I might even try combining say 2C-C with DOM in future, pending that I can replenish my exhausted supplies...


PLEASE NOTE: Because of their known competetive MAOI properties, I decided that using any of the 2C-T-x range in combinations just wasn't worth the risk.

 

[Reminisant B]

^That's interesting stuff.

Almost as though by combing in pairs with each other you better categorise them as well as understand them? Have had about 4/5 2c's but never thought to do this until they were all gone.

Didn't know 2c-t's had maoi properties...all the more evidence not to take 20 2c compounds as was my original thought.

 

[Jabberwocky]

Well with a reduced scope of choice, i've done this with various 2C- combinations in the past, mostly with 2C-B/2C-C/2C-D/2C-E/2C-I in 2 or 3 drug combinations at half/third their respective normal full activity dose for me. While any combination of 2C-B/C/I didn't produce anything of note (probably due to the similarity ie 4-halogen substituted), 2C-C & 2C-D was quite interesting in that it gave it a depth that was grater than you would normally get fro 2C-D alone (2C-C just isn't that deep unles administered via nasal/rectal/imjection administration or at silly/stupid oral doses), almost being 'son of 2C-E', but with a reduced body load. I founf 2C-E + 2C-I to have an uncomfortable push and can't say I recommend it although using 2C-E with 2C-C, which is almost sedating by comparison might be worth the effort.

I might even try combining say 2C-C with DOM in future, pending that I can replenish my exhausted supplies...


PLEASE NOTE: Because of their known competetive MAOI properties, I decided that using any of the 2C-T-x range in combinations just wasn't worth the risk.

What about 2CB and 2CE, ou didn't mention what you thought about that? I LOVE 2CB visuals but miss the depth of 2CE. Theoretically it could go: 4mg2CE+6mg2CB, rectal, followed by perhaps 2mg2CE+2mg2CB

 

[B9]

^ wow ! Lucky you!

 

[yoyoman]

Well,

2C-T-21 and 2C-C = WOW!

Just about 6mg T21 and 20-30mg 2C-C, its like a whole new drug, there's nothing like it.. COLOR perception gone WACK! (in a very good way!)

Everywhere you look, you see color, went to take a piss and the toilet was BLUE (white normally), just from the little bit of blue sky light coming in from the window..

A look in the mirror at myself i'm totally multicolored. No such thing as "white".

Mental control over the visuals (not just colors, amazing visuals!)/colors.. a look outside at a red car, it just turns BLUE (just as deep a blue as the car is red). Only time I saw any "white" was when staring outside long enough to "try" to see everything in black & white (like a bw photo).

Everyone else who's tried the combo - same thing, i'd say, here.. check out the "pretty colors", hour or two later they come back "OH MY GOD! THE COLORS!"

 

[djfriendly]

Why stop at 20?

Why not combine 40 different drugs? How about trying .1µg of every drug known to man simultaneously? Lets try to keep those toxicology fellows on their toes.

 

[Aidan of TCC]

The biggest combo I ever managed was...lets see...

Marijuana, nicotine, alcohol, dexedrine, adderall (I've always wondered, do you count l-amph and d-amph as one drug or two?), mdma, lsd, nitrous, oxycodone and alprazolam, not listed in any particular order.

My god the body high was unbelievable, I was just writhing on the floor in absolute pleasure and intoxication.

Combining drugs is like mixing drinks or cooking, the way I see it. You have a small number of elementary flavors to work with, and different ways to achieve them. You also have at your disposal some exotic flavors to be used sparingly.

Your combination shouldn't be overwhelmed by a single flavor, it should be balanced with the subtleties of each substance giving depth to the experience.
For instance, doing a line of meth, a line of MDA/MDMA and a line of coke is a very silly combination. It's like having candy for dinner, and about equally nauseating in my experience.

An exotic flavor can't save a bad combination...for instance, while on meth/coke/mda/mdma and feeling like shit, I thought I may as well try ketamine for the first time while I was at it. That's like salting down your candybar dinner to save it, and was very dumb and I paid for it in dry heaving.

Similarly, don't load up on exotic flavors alone...no one likes a wasabi/horseradish/soy sauce sandwich, the same way no one likes ketamine, 5-meo-dmt, soma, harmaline and nutmeg.

Any two or three mainstream hallucinogens, stimulants or depressants makes for a good solid base intoxication, in my personal opinion. From there a depressant/stimulant/hallucinogen from a different sub-class always adds more to my experience than doubling up...for instance, add alprazolam to oxycodone as opposed to adding alprazolam to diazepam.

Then of course there's some flavors that go with everything...marijuana, tobacco, alcohol, just like in cooking.

Maybe I'm the odd man out, but I've never liked "redundant" combinations..2c-i+2c-e+2c-b+mescaline etc.. or mushrooms + lsd. I always feel like the two drugs are fighting against each other rather than working with each other.

 

[specialspack]

Why stop at 20?

Why not combine 40 different drugs? How about trying .1µg of every drug known to man simultaneously? Lets try to keep those toxicology fellows on their toes.

Quite. Isn't this board nominally about harm reduction?

I don't think boasting about the biggest number of drug's you've combined is really a suitable topic for ADD is it? There's plenty of combo threads in PD etc...

 

[fastandbulbous]

What about 2CB and 2CE, ou didn't mention what you thought about that?

Might be because I've only ever combined 2C-B with 2C-D (out of the 4-alkyl 2C-x's) and that was only a couple of weeks ago (if you read my trip report for desoxypipradrol, that combo caused a female friend to laugh until she puked!)

 

[Jabberwocky]

Ah, 2CD is a chemical I have not tried...........there are so many 2C's, but 2CE and 2CB are SO good I dont know if I should try the others since I dont try psychedelics much these days anyways so I want it to be a nice experience when I do.

Anyways, I'll keep the laughing til you puke in mind! Sounds fun!

 

[egor]

The psilocin analogs dont always like to play with others.

last time I laughed til I puked was on 7g P. cyancens and really good weed.

 

[Jabberwocky]

holy shit 7g! I hope they were from a third or fourth flush! 7g's would do something very very overwhelming to me. I would probably fly off the face of the earth. 1.5g's of cyans from a first flush were enough to give me one of the strongest +++'s I've had yet.

 

[illusion25]

Do all 2cx's stimulate the same 5ht receptor site. If so then this would work out great.
But if different 2Cx compunds stimulated different receptor sites then take a low dose of a bunch of then would be a waste.

Any info on this?