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MEGA potent drugs

D

DylanG204

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Joined
Jun 7, 2012
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123
If somebody develops some kind of drug , and assumes 100 ug is a good starting dose for any chem and they od



Is it possible for a drug too be active at doses lower than 1 ug , is there a possiblility there could be a super drug like this?
 
It all comes down to how many molecules are in that 1ug, but lsd is distinguishable from sober state at around 25ugI believe, it's most definitely possible as long as there are enough molecules to get to a respectable amount of receptors
 
Also, ethanol is probably the simplest drug molecule wise, meaning each molecule weighs very very little, the problem you run into is finding a molecule that isn't too heavy as to have enough to hit your receptors
 
Is it possible for a drug too be active at doses lower than 1 ug , is there a possiblility there could be a super drug like this?
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Yes, some fentanyl analogues, and things like ricin/aflatoxin can be toxic at ridiculously small levels.

But generally the super-potent narcotics are not happened upon by chance, they are the result of careful computer modelling to make a molecule the "best fit" for the receptor.

It is unlikely that someone is going to invent a novel psychedelic and then immediately die from ingesting 25 ug ... perhaps if you werre synthesizing strychnine anlogues.
 
lsd is a very big molecule than say 2ce


how does it make sence more lsd fits in 1 ug than 2ce would

it has a way bigger molar mass , or is it just activating more receptors>?


so your saying if a drug activates many different receptors or more than one at a atime makes it more potent??


i think weight or volume has nothing too do with it ?

more like what the drug is doing or how large of an effect it has every molecule , like 1 ug of lsd has less molecules than 2ce but it has a much larger responce?
 
drugs and receptors are kinda like this:
images.jpg

the better it fits, the stronger the response, and the less of it you need to activate the receptors. also, receptors arent digital (on/off), there are different amounts of "activated" a receptor can be, and different shapes control how "activated" the receptor is. (ex: how much cAMP the protein releases)
 
that was very help full thanks alot , wonder what the dosage for future drugs wil be when we start getting "perfect" fits if it is possible
 
It depends on the protien targeted and the characteristics of the drug.
The dosages of lots of drugs are limited, because although the drug binds well to its target, it is poorly absorbed, rapidly metabolised, or excreted and hence doesn't get a chance to act.

Examples of incredibly well-fitting "designer" drugs:
LSD at serotonin 5-HT2a as an agonist. Also, the 25xNBOMe and 25xNBOH series.
AM-2201 at cannabinoid receptor CB1 as agonist.
Selegiline at MAO-B.
Escitalopram at SERT.
MDPV at NET/DAT.
Clonidine at alpha-1 adrenergic receptors as an antagonist.
Fentanyl and its cousins at mu-opioid receptor.
MK-801 at NMDA glutamate receptor.
 
http://en.wikipedia.org/wiki/Carfentanil

"with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals.[3] Carfentanil is intended for animal use only as its extreme potency makes it inappropriate for use in humans."
 
DOB said:
dragonfly dob.... I consider this chem to be king of exotic psychedelics,its potency is like... its like F1 race car of phens family
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LSD is far more potent than Bromo-DragonFLY. If DragonFLY is the F1 of psychedelics then LSD is a space shuttle. LSD is absolutely ridiculously potent. If we're talking about physical danger then yes, Bromo-DragonFLY is more dangerous but then again LSD is one of the safest drugs on earth physically. 25C-NBOMe is also in the same league as Bromo-DragonFLY. In fact, considerably stronger. 500ug 25C-NBOMe insufflated is already a quite heavy dose.
 
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Alexander Shulgin used to theorize about chemicals that would began effect of the femtogram scale which would be completely absurd. When it comes down to it I would have to say that the most potent drug would have to be my dream drug of 4-F-Ohmefentanyl. I mean a suitcase of the stuff could cure all the pain in the world.
 
ungelesene_bettlek said:
I wonder how potent DOTFM-dragonfly, NBOME-2C-TFM or NBOME-TCB-2 would be in humans...
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The effects of substituents are not always additive because of steric effects. 2C-TFM-NBOMe has been made, and it has weaker binding to 5HT-2a receptors than the I or Br analogues. The NBOMe derivatives of the DOXs are weaker than the parent compounds.
 
Keep in mind, when Hoffman reported his first LSD experience at 250 micrograms, his colleagues repeatedly asked him if he was SURE he had his measurement right. It seemed an absurdly small dose at the time. I'm open to the idea of something being active at less than one microgram, incredible though it would be. The absolute lightest, unnoticeable except to rigorous scientific testing, effects of LSD begin around 7 micrograms.

Shulgin always began at 1 microgram for this very reason, though I think the next jump after that was to 10 micrograms, and then to 100. Assuming the molecule was extremely potent, and the dosage response curve very steep, the worst that could happen would be he tripped really hard on an unknown compound for an unknown length of time. That he's alive today after testing thousands of new compounds seems to suggest his method worked.
 
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