perpetualmotion288
Greenlighter
- Joined
- Feb 24, 2017
- Messages
- 16
I am researching the topic of lithium and hallucinogenic drug induced seizures, along with the accompanying altered mental states (fugue state, confusion) and other physical symptoms that are frequently noted with these combinations.
It presents as severe serotonin syndrome on most levels, but from the VERY few clinically documented cases in the literature it seems hyperthermia is not at the level commonly seen in SS.
Neuroleptic malignant syndrome can present in the same way with a generally lower body temperature than SS.
I believe a combination of the possibly toxic serotonin levels and metabolites of LSD and substituted amphetamine analogues with an affinity for dopamine receptors to possibly also be causing NMS, and this needs to be looked into as antipsychotics commonly administered could possibly worsen the outcome of NMS.
Lithium is known to precipitate both SS and NMS.
I have searched for weeks, and have compiled quite a bit.
But, I'm missing some specific information that would prove quite helpful.
Clinical information, such as:
-Was body temperature elevated and exact temperature if possible?
-What was heart rate and blood pressure?
-Were tremors present prior to any more severe symptoms and in what extremities?
-What was the elapsed time from ingestion to loss of orientation?
-Were seizures present and how did they present (ex. Limp, shaking, etc)?
I'm taking liberty in assuming LSD to actually be one of many trippy drug with high affinity and activity in microgram to single digit miligram levels commonly sold as "LSD" when I read reports unless noted otherwise.
If proven through GC/MS to be a specific drug or obtained through a RC vendor with verification please note it as so in your response.
I am also interested in MDMA or similar drug interactions.
Dopamine agonist/reuptake inhibitor interactions are also of value to me if tremors or altered mental status occurred.
It presents as severe serotonin syndrome on most levels, but from the VERY few clinically documented cases in the literature it seems hyperthermia is not at the level commonly seen in SS.
Neuroleptic malignant syndrome can present in the same way with a generally lower body temperature than SS.
I believe a combination of the possibly toxic serotonin levels and metabolites of LSD and substituted amphetamine analogues with an affinity for dopamine receptors to possibly also be causing NMS, and this needs to be looked into as antipsychotics commonly administered could possibly worsen the outcome of NMS.
Lithium is known to precipitate both SS and NMS.
I have searched for weeks, and have compiled quite a bit.
But, I'm missing some specific information that would prove quite helpful.
Clinical information, such as:
-Was body temperature elevated and exact temperature if possible?
-What was heart rate and blood pressure?
-Were tremors present prior to any more severe symptoms and in what extremities?
-What was the elapsed time from ingestion to loss of orientation?
-Were seizures present and how did they present (ex. Limp, shaking, etc)?
I'm taking liberty in assuming LSD to actually be one of many trippy drug with high affinity and activity in microgram to single digit miligram levels commonly sold as "LSD" when I read reports unless noted otherwise.
If proven through GC/MS to be a specific drug or obtained through a RC vendor with verification please note it as so in your response.
I am also interested in MDMA or similar drug interactions.
Dopamine agonist/reuptake inhibitor interactions are also of value to me if tremors or altered mental status occurred.
