MDMA with no negative after effects

[EntheoDjinn]

Hope this is the right place for this - it seemed to lie somewhere between basic and advanced.

A while ago I acquired a small amount of MDMA crystal (clear xstals). It checked out for MDxx with Mecke and Ezy tests. On orally ingesting 2mg/kg body weight it felt like seriously good quality MDMA.

The strange thing is, there was absolutely no uncomfortable come down when it wore off, or depletion during the next week. I took this crystal three weekends in a row, and still no depression of any kind - mental or physical. Now I'm normally resistant to after effects on account of judicious use and, I think, something unique to my personal constitution. But this was so clean that it makes me very curious.

My question is really to those out there who are familiar with what "pure" means (or older folks that experienced legitimately-made MDMA back in the pre-illegal days) or chemists.

I always thought that the serotonin depletion was a consequence of the effects of MDMA, not due to a lack of purity.

E

 

[Recept]

I think the worst ecstacy comedown is usually associated with a combination of MDMA/MDA and (meth)amphetamine, which is commonly used in pills. I've never felt any depression after pure MDMA use, my guess is the serotonin depletion only comes into play after heavy use (either too much in one night or several days in a row).

Edit: people are probably different in that aspect though, some people get a horrible crash even after single MDMA use. Each person's brain chemistry is different - I suppose serotonin reproduction is more effective for some people than others.

 

[DragonFly31]

I remember reading in serious research papers that a certain percentage of the population will be more sensible to the depletion of serotonin than others.

Even further, some data suggested that some people will have terrible comedowns off one dose and others none at all, depending which star you were born under.

 

[MeDieViL]

serotonin depletion is not a big issue, i'm not sure but i sometimes suffer from comedown and sometimes dont

 

[kidamnesiac]

having taken mdma of >97% purity, I can say that I experience a nasty next couple of days on any dose

 

[Adrenochrome]

Ya, ok maybe for a few weekends it was like this, but i doubt you'll ever be able to achieve the same degree of absense of after effects
I had very similar sentiments with heroin as your describing...

 

[Splatt]

Have used pure, not just crystal/powder (remember that can still be impure) and it was like i thought what coke and ecstasy would feel like at the same time, for 6 hours smooooth up, smoooth down.. no real munt on your ass or energy to it.. just smooooth. i did use about 400-500mg that night though, because of not being aware that real mdma takes like an hour or more to reach a peak. i dont know what impurities or additions to pills they put in them to make them kick in fast and just munt/smack you out. leftover safrole-type impurities? dunno. but ive had crystals/powders too before that had the same effect as street pills tested as mdma only but obviously not a pure product.

i dont get it. with this 98% clean mdma i had, it was like sometimes i was so high i didnt realise it, and i thought i was straight.. even tho each blissful breath in my nose made me feel like i was rising up. At 125mg of this stuff, there so no retarded looking munt out face pulling, or no excess energy.. it was stuff i would actually SEE used in therapy.

has anyone ever thought that most of the mdma made these days is pretty impure, much like meth went, and even LSD. Who wants to spend more time making a drug thats worth money, and losing product while losing money when the demand is there.....

and that 125mg of most mdma would be unsuitable in therapy, as the person's eyes would just be flickering back and you would be gurning and kind of just anti social munted out, not talking coherently.

pure mdma is being in total control,.... snorting this stuff though did munt you out, but it was still clean feeling. and there was still no comedown.

oh, for the 400-500mg dose i had, there was a bit of a comedown.. i definitely didnt sleep easy and did look a bit messed the next day but there wasn't tuesday blues after a good pass out lost time nap later in the next day.

 

[YuriNass]

When SWIM first started taking E, he would wake up still feeling fabulous. This was about his first 5 times. Every time he would roll after that, he would wake up with the ol' "I'll never do E again". But still, even though he does not do them often anymore, it varies from pill to pill on how bad his hangover is.

You may have a naturally high amount of the chemicals that MDMA deplete, or your body is able to reproduce them easier. But there are still some more things that may contribute to this. What I got from your post is that you do it on the weekends, and while a lot of people suggest a bit longer between rolls a week break is fine for most people. It is when you start doing it multiple days in a row that the hangovers become prominent. Also, since you seem to have mostly pure MDMA you are not dealing with chemicals like meth, dxm, and and god knows what else in street ecstasy that will definitely make it more likely for you to have a hangover.

I'm jealous

 

[fastandbulbous]

having taken mdma of >97% purity, I can say that I experience a nasty next couple of days on any dose

It's dependant upon genetics ie. how much of the MDMA/MDA you metabolize into alphamethyldopamine, which is a false neurotransmitter (body treats it as if it's dopamine, but it has only a fraction of the activity). Alphamethyldopamine is known to cause severe depression as it's the active metabolite of the antihypertensive alphamethylDOPA (Aldomet)

 

[LuxEtVeritas]

^

yup as well as likely several other enzymic factors that are varied in each individual and their genetic makeup

also i always found it interesting that alphamethyldopamine has such effect yet alphamethylphenethylamine (AMPH) is so potent

 

[Adrenochrome]

Perhaps juxtaposing their IUPAC names would help elucidate their dissimilarities for you:
Aldomet : 2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid
Amphetamine : 1-phenylpropan-2-amine

 

[fastandbulbous]

Might be easier looking at the structures (below)

 

[LuxEtVeritas]

oh i know all these structures from memory as i am highly familiar with this class

i just know MOST phenethylamine based structures are more potent with the alpha-methyl and this is the opposite

obviously though here and i believe with a-methyl-Epi/NorEpi th different receptors and mode of action cause the opposite in potency