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MDMA overuse (high doses), and a significant worsening of sleep problems

mborowiec512 said:
Hey,
Thanks for answer!

Did you recover 100% from mentioned information processing abilities?

I will take into consideration also taking melatonin (haven't tried) and hydroxyzine (need to try in higher dosage).

What did you refer to with this study?
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My cognitive functions did come back after stopping the meds (around two months after stopping risperidone, the latter one) but for the last couple of years after lamotrigine I still have been struggling with a shattered circadian rhythm. Another thing is that I took them for a very short time (each less than a month) so I probably dodged the truly long-term effects.

As to the quoted study, it gives reason to believe that combining an antipsychotic with MDMA shouldn't make long-term effects more pronounced. I'm guessing that the complications aren't synergistic to a significant extent. There's no way of knowing whether whatever parts have been caused by MDMA are gonna be alleviated but if the quetiapine is causing certain symptoms it's probably best to tackle that problem first as it's doable in a fairly small timeframe. As fairnymph said, it might be a good idea to stop any meds that aren't crucial, but it'd certainly be a gamble.

And a tangent about antidepressants, have you tried MAOIs or atypical ones? I know the former aren't prescribed often nowadays due to the side effects and interactions but I've heard of treatment-resistant depression cases deemed irreparable made better with MAOIs. Then as to the atypical ones, one of my friends got much better after taking tianeptine (SSRIs and tricyclic antidepressants didn't work). Consider talking about these with your psychiatrist.

I also wanna warn you about biofeedback, it made my neurologic issues MUCH worse; I do recognise it can be helpful though. If after a few sessions you're feeling worse than before, dropping it might be best course of action.

Either way, I hope it gets better for you, you've probably still got a long, nice life ahead :)
 
fairnymph said:
Why take such high doses of MDMA? Your problems do make sense given you’re prescribed is a serotonergic (among other things) drug. My guess would be that you’ve done some hopefully only short term damage to your serotonin and possibly other receptors which only time can heal. I think you’d be better off switching to another sleeping med that doesn’t impact serotonin receptors, at least temporarily. If you tell your doctor it’s not working and you need high doses which you can’t tolerate, hopefully he will give you something else, at least a z-drug. Have you ever tried going a few days without taking any quetiapine at all? Given its complex mechanisms of action I’m concerned that it might be inhibiting your healing. If you could be on nothing at all for several months while you focus on optimising your health that would likely be ideal. If that’s not an option because of severe insomnia, then I would use a GABAergic drug, as minimally as possible - if possible, no more than every third night, for a few months. But I really need to know more about why you’re taking it to begin with and how bad your insomnia is.
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emkee_reinvented said:
Quetiapine, according to the dutch Dr medication Bible.
Off label use as sleep medication is discouraged and disadvised.

If your not psychotic, your dr is wrong. But as Fairnymph already wrote.
Your MDMA consumption is over the top. And isn t Quetiapine also anti-emetic ?

Which would indicate the naussea has a other source.
Too much MDMA, and/ or to little fluids and food ?
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tetrahedral said:
The cognitive problems may be worsened by the larger dose of quetiapine, especially when you're probably already sleep deprived. I've had risperidone and lamotrigine wreak havoc on my information processing abilities. Also, does stuff like melatonin supplementation work for you? Maybe hydroxyzine would be better for sleeping?
There's also this study of haloperidol and MDMA combined that showed insignificant effects just after three days although the sample size was like two dozen people and it was a noticeably smaller dose (1,5mg/kg of body mass), so I'm guessing what you're experiencing is not likely a common effect. (Liechti and Vollenweider, 2000)
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sHR00m said:
Quetiapines sedative properties are attributed to the H1 receptor though, not the serotonergic activity. In fact there shouldn't be serotonergic receptor activity at low doses usually given for sleep.
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I'm kindly asking every of you if you think that
A)200mg of quetiapine daily
B)20mg of Vortioxetine daily
C)300mg of Bupropione daily
can make my recovery level from MDMA overuse smaller? I want to sum up
 
sHR00m said:
Quetiapines sedative properties are attributed to the H1 receptor though, not the serotonergic activity. In fact there shouldn't be serotonergic receptor activity at low doses usually given for sleep.
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Occupancy level of 5-ht2a for quetiapine 150 mg dosage equals 20%. For 450mg it's 57%
 
mborowiec512 said:
I'm kindly asking every of you if you think that
A)200mg of quetiapine daily
B)20mg of Vortioxetine daily
C)300mg of Bupropione daily
can make my recovery level from MDMA overuse smaller? I want to sum up
Click to expand...
Well you mentioned the Quetiapine is prescribed for sleep,
and for sleep only. Correct when wrong. but its indicated for:

-Schizophrenia
-Bipolar/ Manic episodes
-Prevention Manic or Depressive episodes with Bipolar
-Off Label use: treating a Delier in patients with a hyper kinetic syndrome.
Like Parkinson. No dr. just typing whats written in our medical bible.

Not for sleep. So drop and swap for a milder anti-Histamine.
And don t take Quetiapine around MDMA, chance for Serotonin Syndrome.
 
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