Harm Reduction MDMA, Meth & ODSMT?

[Cult315]

Is there a risk of serotonin syndrome with this combo? To be clear, I dosed roughly 80mg of the ODSMT at about 3pm(6pm now), effects are still felt pretty strong. I’m a daily user of meth, and have not done any MDMA(that was worth a shit, anyway) in at least a year I think. I plan on dosing 80-100mg of it around 9-10pm tonight.

I know tons of E pills are pressed with a combo of Meth/MDMA so I’m assuming the combination is safe enough, and while I don’t know fuck all about chemistry I’m assuming due to how closely related the two are they kind of just work together? Anyway, long story short is it safe to combine those two, and is it safe to continue to smoke meth while on the MDMA? I’m sure I can manage not to for the duration of the roll if it’s unsafe, just wanted to be sure if it’s safe to do or not.

I don’t plan on taking any more of the ODSMT, I’d dosed it before I realized the MDMA was here. I’ve heard it doesn’t have the same SNDRI? properties of Tramadol itself, but don’t know if it effects serotonin at all and I’m a bit concerned about it. If it does, is 6-7 hours enough time for it to be out of my system enough to roll?

 

[Joey]

I did a meth and mdma combo once. It wasn't the greatest feeling. I had to lay down for a bit. It's probably a better idea to hold off on smoking meth while you roll. There's a good chance you'll find it feels weird if you keep smoking on it. Unpleasant.

I don't know what ODSMT is so no comments on that.

 

[Cult315]

I did a meth and mdma combo once. It wasn't the greatest feeling. I had to lay down for a bit. It's probably a better idea to hold off on smoking meth while you roll. There's a good chance you'll find it feels weird if you keep smoking on it. Unpleasant.

I don't know what ODSMT is so no comments on that.

Thanks for the info man, I’ll just stick to the MDMA itself then.

I’m gonna look on psychonaut wiki and see if ODSMT is in the red for interactions with MDMA I guess, if not I’m gonna hope I’m good lol. It’s o-desmethyltramadol btw, something tramadol metabolizes into in the body. It’s a bit more potent than tramadol itself but afaik it doesn’t have the SNRI or SNDRI, whichever it is, properties that the parent drug has so I’m hoping I’ll be all good.

 

[funafternoon666]

I think O-DSMT does not affect serotonine, but microsoft copilot says the opposite. I'm on a combination of O-DSMT and dexamphetamine right now. I did not
get the dosage of the ODSMT right I'm afraid, because I'm experiencing next to nothing.

 

[LucidSDreamr]

both (+) and (−)-desmetramadol are inactive as serotonin reuptake inhibitors, but (−)-desmetramadol retains activity as a norepinephrine reuptake inhibitor,….Desmetramadol is also an antagonist of the serotonin 5-HT2C receptor, at pharmacologically relevant concentrations,

MDMA and meth release norepinephrine


I wouldn’t mix this; you don’t want norepinephrine overload …it’s a nasty feeling and dangerous.

The antagonism at the 5HT receptor by ODMT is also going to ruin the serotonergic (and good) aspects of the mdma and Meth.

 

[Cult315]

both (+) and (−)-desmetramadol are inactive as serotonin reuptake inhibitors, but (−)-desmetramadol retains activity as a norepinephrine reuptake inhibitor,….Desmetramadol is also an antagonist of the serotonin 5-HT2C receptor, at pharmacologically relevant concentrations,

MDMA and meth release norepinephrine


I wouldn’t mix this; you don’t want norepinephrine overload …it’s a nasty feeling and dangerous.

The antagonism at the 5HT receptor by ODMT is also going to ruin the serotonergic (and good) aspects of the mdma and Meth.

Thank you for the informative response dude. I last took the ODSMT at 3pm and don’t plan on dosing the MDMA until 9pm(1 hour from now), or maybe 10pm. Do you think the effects or whatever mechanisms that would effect the roll would be gone by then? By now I would normally be re-dosing, but obviously I’m skipping it and I don’t really feel any effect at this point.

Also would consuming no more meth between now and the time I drop the Molly be good enough to prevent any norepinephrine overload?

I’m surprised you say the ODSMT would negate good effects from meth, though. I’ve been doing this combo for a little while now and it makes me feel great and as far as I can tell not any less stimulated or anything. I’m glad I asked this though because I almost figured since I do meth/ODSMT all the time that adding MDMA wouldn’t hurt, but was skeptic oh my own logic lol.

 

[LucidSDreamr]

Thank you for the informative response dude. I last took the ODSMT at 3pm and don’t plan on dosing the MDMA until 9pm(1 hour from now), or maybe 10pm. Do you think the effects or whatever mechanisms that would effect the roll would be gone by then? By now I would normally be re-dosing, but obviously I’m skipping it and I don’t really feel any effect at this point.

Also would consuming no more meth between now and the time I drop the Molly be good enough to prevent any norepinephrine overload?

I’m surprised you say the ODSMT would negate good effects from meth, though. I’ve been doing this combo for a little while now and it makes me feel great and as far as I can tell not any less stimulated or anything. I’m glad I asked this though because I almost figured since I do meth/ODSMT all the time that adding MDMA wouldn’t hurt, but was skeptic oh my own logic lol.

The half life is 8 hours so you’ll absolutely still have active ODMT drug on your system.

If you do proceed I’d definitely want to have benzos on hand if it were me

 

[Cult315]

The half life is 8 hours so you’ll absolutely still have active ODMT drug on your system.

If you do proceed I’d definitely want to have benzos on hand if it were me

I do not have any benzos. I’m a bit confused though, what exactly is the negative effects if I take MDMA 7-8 hours after an ODMT dose?

 

[LucidSDreamr]

I do not have any benzos. I’m a bit confused though, what exactly is the negative effects if I take MDMA 7-8 hours after an ODMT dose?

You still have active ODMT in your system (half what you did at peak concentration) and it’s a norepinephrine reuptake inhibitor while MDMA is a norepinephrine releaser.

Norepinephrine is responsible for the dirty jittery feeling of stimulants. Have an overload of it and have a bad time.

 

[Cult315]

You still have active ODMT in your system (half what you did at peak concentration) and it’s a norepinephrine reuptake inhibitor while MDMA is a norepinephrine releaser.

Norepinephrine is responsible for the dirty jittery feeling of stimulants. Have an overload of it and have a bad time.

If I keep off the meth until(and after I drop) would it keep the risk of norepinephrine overload? Would it level out to the same as odsmt/meth together? I do that combo often and never suffer an ill effects. Is MDMA more potent in norepinephrine release than meth?

I don’t have any benzos but I do have a ton of gabapentin, which I regularly used when I’d get overstimmed from meth when I first started. Would that help like benzos?

In all honesty I think I’ll be alright, I found a bunch of Reddit posts of people saying they’ve done odsmt in combo with MDMA shortly after each other and suffered no ill effects. But if I’m told it’s dangerous in here I’ll avoid - just really want to do it tonight and if it’s deemed safe enough I really want to lol

 

[LucidSDreamr]

If I keep off the meth until(and after I drop) would it keep the risk of norepinephrine overload? Would it level out to the same as odsmt/meth together? I do that combo often and never suffer an ill effects. Is MDMA more potent in norepinephrine release than meth?

I don’t have any benzos but I do have a ton of gabapentin, which I regularly used when I’d get overstimmed from meth when I first started. Would that help like benzos?

In all honesty I think I’ll be alright, I found a bunch of Reddit posts of people saying they’ve done odsmt in combo with MDMA shortly after each other and suffered no ill effects. But if I’m told it’s dangerous in here I’ll avoid - just really want to do it tonight and if it’s deemed safe enough I really want to lol

I can’t back this using pharmacology at the moment - but I would rather combine mdma with ODMT than meth with ODMT.

So if you cut out the meth it should be better. I say this because meth is far more stimulating than mdma and the only danger is possibly getting too overstimmed.

Ppl on drug Reddits are retarded so take what they say with a grain of salt.

If you do meth and ODSMT without problems normally I think mdma/ODSMT would be less of a problem; but that’s just my opinion.

 

[someguyontheinternet]

You still have active ODMT in your system (half what you did at peak concentration) and it’s a norepinephrine reuptake inhibitor while MDMA is a norepinephrine releaser.

Norepinephrine is responsible for the dirty jittery feeling of stimulants. Have an overload of it and have a bad time.

NE overload is 100% a nasty time. Like uncontrollable shaking/shivering, heart palpitations, intense anxiety. Definitely something to avoid...

 

[Cult315]

I can’t back this using pharmacology at the moment - but I would rather combine mdma with ODMT than meth with ODMT.

So if you cut out the meth it should be better. I say this because meth is far more stimulating than mdma and the only danger is possibly getting too overstimmed.

Ppl on drug Reddits are retarded so take what they say with a grain of salt.

If you do meth and ODSMT without problems normally I think mdma/ODSMT would be less of a problem; but that’s just my opinion.

Yeah I’m aware of the retardation of Reddit drug users/posters, but typically if I can’t find much info elsewhere it’s a decent source for whether I’m going to have a bad time based off other peoples experience. I know enough to look for multiple sources of info, or in this case multiple people claiming they’ve done MDMA + ODSMT with no bad effects, but not enough about how NRIs and drugs that release norepinephrine work to pass my own judgement on it.

The only reason I really questioned what you were telling me is because I figured since Meth is a more potent stim and I’ve been perfectly fine actively combining it with ODSMT, then why would MDMA be worse(as long as I took more meth intake out of the equation, anyway). But I also failed to mention, mostly because I just didn’t think of it, that I’ve been on a combination of stimulants and opiates for the better part of ~17 years. And for about 4-5 of those years my daily intake was huge quantities of Tramadol and Adderall, which amazingly never resulted in serotonin syndrome and as far as I could tell(or remember) never left me feeling overstimmed/edgy or any other physically negative symptoms.

I know I probably shouldn’t, but I’ve taken the risk into consideration and I’m gonna just do a lowish(80mg) of the MDMA and hope for the best. In the case I am overstimmed though, so you think gabapentin would help?

 

[Cult315]

Well in case anybody was curious, I ended up doing the MDMA and there was about no effect lol. About 45 minutes after dosing(100mg), I felt a very mild, but familiar, come up feeling followed by just a slight euphoria. I actually got pretty jittery and a little uncomfortable, and slightly nauseous. Other than that I felt pretty normal, mostly just like I’d smoked some mid-quality ice. 20 or so minutes into the start of the “roll” I decided to dose another 50mg. The second dose never gave me a feeling like it kicked in, other than I ended up increasingly anxious throughout the night. My fiancé is also a daily meth user, and we both dosed exactly the same of the MDMA and she noted zero effects other than also feeling jittery/anxious, feeling like shit(her stomach hurt) and she was cold. She’s always fuckin cold, though - but I was pretty hot. Not like overly or feverish hot, it’s just hot in our room between the heat and my PC usually being on. I’ll note that she didn’t take any of the ODSMT on the day of the MDMA and she felt no good effect from it while I did (just ever so slightly) and her negatives seemed to be more intense than mine.

Tbh I should have listened to you guys in the thread, but I was determined and we both were really looking forward to a good roll and having empathogen-fueled sex all night - neither of which happened. I quit using the meth ~2 hours before dosing the MDMA, which apparently was not enough time as the two definitely synergised, just in a shitty way. I also got some damn good meth along with the MDMA, it blew pretty much all of the shit I’ve been using for the last 5+ months out of the water. So that may have something to do with it as well.

But yeah, I don’t think the ODSMT I had taken about 8 hours prior to the roll effected it any, just the meth that I’d only stopped a few hours beforehand and was definitely still high from(since it was much better shit than I’ve been used to). Overall I rate the entire experience 1/10 and definitely do not recommend even trying to use MDMA while 1. Under the influence of meth and 2. During an active meth habit, without a good long break. Like days or weeks, not hours. I can’t remember if somebody above mentioned it or not, but my serotonin/dopamine is for sure depleted which definitely makes it so MDMA is pointless to take. I just felt good for a few minutes and then uncomfortable/kinda shitty and anxious for the next few hours.

At some point I’m going to try to stay off ice for a week or 2, or at least a few days, and try a bigger dose just to see if I can roll. My girl really, really wants to roll with me so I gotta figure a way to make it happen lol. The last time we did it together was when we were about 15-16, and we both were in different relationships then. But you could tell how bad we wanted to touch/fuck each other. And while my girlfriend at the time wasn’t there, her boyfriend was and even through his everlasting smile-face you could tell he was getting a bit mad/jealous cause she wouldn’t stop hugging me and rubbing my arms and back and saying she loved me… like a friend. Like a friend… I love you… like a friend shit was funny but definitely created tension and made things a bit uncomfortable to be around them for a few weeks til we all forgot about it. But anywho, I’m done typing lol. Don’t mix MDMA and meth, folks. You won’t die or have a crazy bad time. But it’s not enjoyable

 

[deficiT]

Yeah, there definitely is. I've taken it enough on its own, as well as with amph or meth, and just that alone can give one the shakes pretty bad, if you overdo it on dose.

I definitely would not want to add MDMA to that party

 

[Coffeeshroom]

Thanks for all the info and my conclusion from all this. Thay all best used on its own and not mixed-up

Awe

 

[WellTram]

I think O-DSMT does not affect serotonine, but microsoft copilot says the opposite. I'm on a combination of O-DSMT and dexamphetamine right now. I did not
get the dosage of the ODSMT right I'm afraid, because I'm experiencing next to nothing.

O-DSMT is only NRI, not SSrI, SRA, it Is decent opioid with noradrenaline raising effects which Is known since experimenting with morphine and amphetamine that mu opi agonist + CNS acting stimulant = the best analgesia but they probably can't sell OTC tylenol+tram+some amphetamine + some anticonvulsant ( it's great for pain and with tram and tapentadol u dont need amphetamine). Also, there can be some kind od enzyme or receptor binding problem between your stimulant and nri opioid.

 

[WellTram]

Thank you for the informative response dude. I last took the ODSMT at 3pm and don’t plan on dosing the MDMA until 9pm(1 hour from now), or maybe 10pm. Do you think the effects or whatever mechanisms that would effect the roll would be gone by then? By now I would normally be re-dosing, but obviously I’m skipping it and I don’t really feel any effect at this point.

Also would consuming no more meth between now and the time I drop the Molly be good enough to prevent any norepinephrine overload?

I’m surprised you say the ODSMT would negate good effects from meth, though. I’ve been doing this combo for a little while now and it makes me feel great and as far as I can tell not any less stimulated or anything. I’m glad I asked this though because I almost figured since I do meth/ODSMT all the time that adding MDMA wouldn’t hurt, but was skeptic oh my own logic lol.

Because tramadol has more potent monoaminergic and other aphetamine-like properties than opioid abonism and M1 metabolite O-DSMT is just stronger, longer acting much less serotoninergic version. I use tram and ice together often but i seized a few times even with pipe in my hand.....next to my younger family member....but otherwise i can feel that one + other = synergy ( probably dose dependant and can be FATAL )