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MDMA & Diphenhydramine

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Hedonist9

Bluelighter
Joined
Jul 19, 2006
Messages
234
Hi,

does anyone know if there is a point to why some people adulterate Ecstasy pills with dyphenhydramine. Its just benedryl which can make people sleepy?

Perhaps I'm nieve, but why in the world would someone making X add benedryl to it?
 
Becuase they used diphenhydramine pills to act as binders.

It's possible that they know it slightly inhibits the metabolism of MDMA, but I doubt it.
 
BilZ0r said:
Becuase they used diphenhydramine pills to act as binders.

It's possible that they know it slightly inhibits the metabolism of MDMA, but I doubt it.
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WHAT? im sorry but that makes no sense man. I know im a newbie at this place but thats pretty rediculous.

Im a little confused as to what your saying though so maybe im wrong. are you saying that they use the entire pill as a binder? because if thats so, that makes no sense. I know people who press tablets and binders/fillers are very cheap: around 10dollars per kg!

or did you mean that they used the actual Diphenhydramine fora filler? because that doesnt make sense either. An active dose of Diphenhydramine for anti hystamine purposes is 25mg, and 50mg maximim strength for sleeping pill. why would they use this as a filler? a 300mg tablet of X containing 100mg of mdma would contain 200mg of Diphenhydramine!

Hedonist9 look at the pills with the Diphenhydramine in them. do they contain drugs like meth in them? If so they might put some in to calm the jitters. I know when im trying to sleep after crazy coked out night ill drink a few shots and take 100mg of diphenhydramine. i get relaxed and very euphoric, till the coke reaches a low enough level where i can pass out.
 
are you saying that they use the entire pill as a binder? because if thats so, that makes no sense. I know people who press tablets and binders/fillers are very cheap: around 10dollars per kg!
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That's what I'm saying. It's the same reason why you find acetaminophen in there too.
 
People who took those blue diamonds thought they were strong MDMA pills but were wierd when taking more than a few, so i'd assume someone figured out that the combination makes a little MDMA seem like a lot more. Interesting but not unbelievable.
 
I don't think this is a good idea. Diphenhydramine has pharmacological effects other than it's putative SSRI properties, most prominently its antihistamine actions. It's definitely a dirtier drug than Prozac. Overdoses on diphenhydramine alone can be fatal, and the cause of death is commonly cardiac arrest or seizure, which are also two frequent causes of death in MDMA overdoses. Therefore, I'd conclude that this combination may not be safe, though of course dosage is everything. In any case, I think it is foolish to treat diphenhydramine as a substitute for SSRIs.
 
5-HT2 said:
I don't think this is a good idea. Diphenhydramine has pharmacological effects other than it's putative SSRI properties, most prominently its antihistamine actions. It's definitely a dirtier drug than Prozac. Overdoses on diphenhydramine alone can be fatal, and the cause of death is commonly cardiac arrest or seizure, which are also two frequent causes of death in MDMA overdoses. Therefore, I'd conclude that this combination may not be safe, though of course dosage is everything. In any case, I think it is foolish to treat diphenhydramine as a substitute for SSRIs.
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I agree that yes, it does have pharmacological effects other than its antihistamine and SRI ability, but when taking at the safe correct dosage, would it still help to prevent neurotoxicity?

Im not looking for a replacement for a real SSRI. I just cant get my hands on the real thing, and was wondering if diphenhydramine would prove useful in preventing dopamine uptake after a mdma experience.
 
Could diphenhydramine be taken on the come down of a roll so as to help prevent neurotoxicity by inhibiting serotonin(dopamine) reuptake?
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I don't believe the use of SRIs is a practical tool to prevent neurotoxicity in the first place. They pose their own risks and side effects, and at best would only be a partial solution. Limiting dosages, avoiding overheating and taking some antioxidants are probably much more useful tools.


(edit) The dopamine theory has been discredited.
 
TheDEA.org said:
I don't believe the use of SRIs is a practical tool to prevent neurotoxicity in the first place. They pose their own risks and side effects, and at best would only be a partial solution. Limiting dosages, avoiding overheating and taking some antioxidants are probably much more useful tools.


(edit) The dopamine theory has been discredited.
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Sorry, i was unaware that the dopamine theory has been discredited. I was aware that it was actually credited, and was backed by studies on rats with Prozac which showed a significant reduction in oxidative stress when under the influence of Prozac than when not.
 
TheDEA.org said:
They pose their own risks and side effects,
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i'm sorry but you make those meds sounds like they are horribly dangerous, ppl take them their whole life without a prob

so yes it should help or maybe not if prozac helps because it lowers body temp, but this med might do that to
 
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