N&PD Moderators: Skorpio
Matrine (kappa-opoid agonist) ?
ungelesene_bettlek
Bluelighter
I just came across an alkaloid named matrine, which is found in the traditional chinese medical herb Sophora flavescens, and is said to be active as kappa opioid receptor agonist. does this mean that it could have some Salvinorin-like activity...?
http://en.wikipedia.org/wiki/Matrine
Thorns Have Roses
Bluelight Crew
I think this will get more (qualified) attention over in ADD. So, PD->ADD
ungelesene_bettlek
Bluelighter
yes, that is probably a good idea - thank you for moving!
sekio
Bluelight Crew
Salvinorin is unique among the kappa-opioid agonists that it seems to have a relatively selective & strong agonist activity, producing hallucinations, etc. I have heard that longer-lasting kappa agonists are not as pleasant.
Then again, some compounds do not activate KOR enough to produce hallucinogenic effects.
Either way I wouldn't want to attempt to find a psychedelic dose of this compound.
Sturnam
Bluelighter
I agree with sekio. If this compound last any longer than 15 minutes or so, it probably won't be fun (even to those who enjoy salvia). I have tried butorphanol before and I can tell you it is NOT fun. I just felt really weird and odd for quite a while.
So maybe it has salvinorin-like activity, but I would probably recommend against taking it.
DexterMeth
Bluelighter
I've taken a quite a few intranasal saline squirts of butorphanol in my time, and I find it extremely disorienting; like akin to drinking a 12-pack of beer, but in a few seconds. It also really overheated me. At times even felt like I was on higher doses of DXM, where you can't do anything but lay down, not being able to physically focus my eyes on anything.
I'm assuming I took way too high a dose each time, but still.
sekio
Bluelight Crew
The general consensus I have read is that KOR agonism is not fun or desirable in a drug.
^ Ditto, similar experiences with levallorphan (lorfan) many many years ago. It's a full kappa agonist and a mixed agonsit/antagonist at mu. Euphoria was marginal at best. It was sedating, and very dissociative and spaced out. It felt like how I would imagine it would be to combine a threshold dose of salvia, a low dose of codeine, and a hero dose of ketamine. I have this vivid memory of taking a piss in a public washroom, looking down, getting hit by a tsunami of disorientation and shouting out "what the hell, who's dick is this in my hand?!?"
Fortunately there was no one else around or I might have ended up in a padded cell.
Edit: Yeah this matrine stuff sounds nasty. It's under investigation as an insecticide for termites.