MAO Over-Expression - Is this a thing?

[clog]

Since my last thread didn't get a response I've simplified my question.

Is there any evidence that MAO can be over-expressed due to excessively high levels of specific neurotransmitters?

An example scenario might be long-term high dose amphetamine use. Could this induce MAO up-regulation as a homeostatic response to the high dopamine levels?

Any input would be appreciated. Thanks.

 

[AlphaMethylPhenyl]

If this happens it would be negligible in regards to amphetamine as it hardly affects mao

 

[sekio]

If such an effect exists it is unreported in the literature to my knowledge

 

[ebola?]

But have the necessary studies been conducted to rule this out as a common mode of neural adaptation?

ebola

 

[Epsilon Alpha]

Some evidence points to it occurring in animal models of Alzheimer's
http://www.ncbi.nlm.nih.gov/m/pubmed/11360691/
It also suggests PKC activation (possible relevance to stupid doses of amphetamine?) can selectively up regulate MAO-B
http://pharmweb.usc.edu/shih-lab/Mechanisms for Regulation .html

 

[cannibalsnail]

Progesterone increases MAO levels which leads to the depression side effects from some oral contraceptives.

 

[Epsilon Alpha]

Progesterone increases MAO levels which leads to the depression side effects from some oral contraceptives.

Is it MAO-A or B selective up regulation? Also, sauce please? :3