Making Clorazepate Dipotassium active by itself

[jasoncrest]

Clorazepate Dipotassium is a benzodiazepine, very soluble in water.

The pills contains few binders, and are strong (they contain 50mg Clorazepate = 25mg Diazepam) -> it would be very cool to inject it.

But it needs to be metabolized to nordazepam to be active. It is inactive by itself.

BUT in hospitals, they do Clorazepate intraveinous injection: they dissolve a powder containing Clorazepate + other ingredients in water, and then the Clorazepate can be injected.

I read that this is because one (or more?) of the ingredients in the powder, added to Clorazepate and put in water makes the Clorazepate active by itself.

The powder contains:
-potassium
-potassium carbonate
-monopotassium dihydrogen phosphate

Do you know which one of these substances makes the Clorazepate active?


[I do not have access to Clorazepate made for injection, it's used only in hopitals, but I can get Clorazepate easily, and maybe potassium, potassium carbonate, and monopotassium-- too.]

 

[human]

How does IV'ing the drug inhibit its conversion to the active metabolite?
As an aside, BilZ0r (or anyone else who may know), is there any drug that's active orally but inactive IV'ed? I mean I can think of drugs that aren't safe to IV, but inactive? I dunno, it wouldn't surprise me, I just wouldn't expect it.

 

[fastandbulbous]

^ Can't think of one at the moment, but the only way that would happen would be

a. If the drug could only be converted to it's active metabolite by digestive enzymes, or

b. If the drug was effectively insoluble and because of this was unable to be administered by injection.

As I said, can't think of one for a. but for b., diphenoxylate would qualify as it's nigh on insoluble in water (or much anything else!)

 

[Tokey-tokerson]

How does IV'ing the drug inhibit its conversion to the active metabolite?
As an aside, BilZ0r (or anyone else who may know), is there any drug that's active orally but inactive IV'ed? I mean I can think of drugs that aren't safe to IV, but inactive? I dunno, it wouldn't surprise me, I just wouldn't expect it.

Cocaine w/o hcl

 

[Tokey-tokerson]

Oh yeah and to answer, the original question. Go look up all the ingredients they have in the shot. If you cant get, you could just plug and it would do just as good.

 

[jasoncrest]

Oh yeah and to answer, the original question. Go look up all the ingredients they have in the shot.

That's what I will do, I will get potassium, potassium carbonate and monopotassium dihydrogen phosphate, mix that with Clorazepate in water and shoot...

But it would have been easier if someone happened to know which of the three is the thing I need, and which ones are binders or useless ingredients...

It would have been very cool if someone knew the reaction, like
clorazepate dipotassium + potassium ??? (+H2O) --> the active version of clorazepate dipotassium, clorazepate? clorazepam?

 

[johanneschimpo]

check out the structures fpr clorazepate and nordazepam... if you know some chemistry maybe you can hypothesize which of those buggers will pull whatever off the clorazepate to make it nordazepam

 

[Phat_bass49]

That's what I will do, I will get potassium, potassium carbonate and monopotassium dihydrogen phosphate, mix that with Clorazepate in water and shoot...

But it would have been easier if someone happened to know which of the three is the thing I need, and which ones are binders or useless ingredients...

It would have been very cool if someone knew the reaction, like
clorazepate dipotassium + potassium ??? (+H2O) --> the active version of clorazepate dipotassium, clorazepate? clorazepam?

won't the K just make a hydroxide KOH with water? i wouldn't want to I.V KOH.