m-eslon, is it safe?

[Ubi]

This seems to be the right place to post a question like this.

I'm wondering of all the pain medications of pharmaceutical grade, do you guys think this is of the safest?
They are time released morphine. If used correctly, Dr.s claim they do the least bit of damage compared to others like the oxy family.
What do you think? I'm curious because I've been on them for years now due to head trauma and some major surgeries regarding this and the nerve and bone damages done.

 

[adder]

What kind of damage are you talking about?

Morphine doesn't cause less damage than oxycodone or oxymorphone, I don't think there are any studies done comparing physical changes to opioid receptors caused by morphine and oxycodone or oxymorphone. As for addiction and dependence they are all highly addictive opioids, but morphine's oral bioavailability is much lower than oxycodone's, so while they're more or less equipotent by weight given intravenously, you need much less oxycodone than morphine orally. Sometimes I read that morphine taken orally doesn't produce any euphoria but I've got no idea where this idea comes from. I used to get nice euphoria even from codeine before I moved on to stronger opioids, so I don't know why morphine wouldn't be euphoric orally, you'd only need at least 3 times more morphine orally than intravenously for a similar effect and you wouldn't feel any rush that way. Perhaps by euphoria some people mean euphoric rush, but rush and euphoria may be separated here, levorphanol for instance has no rush even i.v.'ed and it comes on gradually, but it's strongly euphoric.

The reason why oxycodone is so popular among opioid pharmaceuticals is simply because it's both powerful and has a high oral bioavailability while all other strong opioid pharmaceuticals commonly used and heroin have a low or very low oral bioavailability, methadone is probably the only exception. As for the quality of effects different people prefer different opioids, but it's hard to say which one is more addictive, morphine or oxycodone.

 

[Ubi]

Okay, hey thanks for the info. But hey, my Dr.'s told me the time release action on the m-eslon (taken orally) is much safer and they also told me the possible harmful effects on my organs would be less compared to the oxy fam.
I get you on the euphoric effect. I feel them within 30 minutes but never too strong; maybe that's why the addiction seems mild (but it isn't) if I go one day without, the next morning I be hurting somewhat. Go another day and all bets are off.

This is something I need to take for nerve/bone damage for the rest of my life. I guess I was hoping for different results here but there the same hey? DAng. ok. When you say, "very low bioavailability" what do you mean? I know you tried explaining but i'm not getting it, sorry. do you have time to offer more details on that? please?
thanks for the info though, thanks

 

[sekio]

Morphine and its derivatives aren't toxic to organs at all. Generally, drug of poor purity, and poor IV hygeine are what leads to infection and/or oragn damage, not the chronic usage of morphine itself. The only exception I can think of in the poppy-derived alkaloids is hydrocodone, I think I read once that it may be ototoxic (damages inner ear) in some individuals under some vaguely defined circumstances.

Low oral bioavailibility means if you eat the drug then only a small portion of the drug actually makes it to the bloodstream to produce an effect, because of the fact that orally ingested drugs must pass through the liver first, meaning e.g. in morphine's case most of an oral dose (60-70% ) is degraded into other metabolites and only 30-40% of it reaches the blood. Another way of looking at this is parenteral administration of morphine (IM, IV, SC etc) would be ~3.3x stronger per milligram than orally administered morphine.

 

[Ubi]

^ thank you. much appreciated. feel better about it already