lysdexamphetamine and other forms of amphetamine binded to amino acids

[k4rnage]

What is the potential for amphetamine to be binded to other amino acids, like lysine? Could you potentially do it with any amino acid, or does it have to fit a certain profile?

Could you do this with MDMA as well??

I find it interesting because it's so bioavailable, though I don't understand why Vyvanse doses are almost double/triple dexedrine doses enough though Vyvanse is supposedly 100% bioavailable.

So when are we going to see lysmethamphetamine? or any other form of amphetamine binded to an amino acid??

 

[atara]

These are designed to be non-recreational. You're not going to see it done with other drugs because the market is generally in things that get you high.

To answer your question, amphetamine and other amine drugs can be condensed with most carboxylic acids, including all amino acids, yes.

 

[k4rnage]

even though Vyvanse is a prodrug, some (maybe many) still seem to prefer it over Adderall and Dexedrine, and claim it still has recreational value when you take a lot. I haven't tried it myself but it sounds good to me.

 

[NeighborhoodThreat]

I think Vyvanse is more useful for combating ADD/ADHD symptoms because of its slow onset and long long long acting effects...unlike Dexedrine/Adderall which, when crushed, have a nice rush of euphoria that's certainly very recreational.

Personally I think the only reason Vyvanse was put on the market was because the pharm company wanted to make it "less abusable" and therefore Schedule III instead of Schedule II...which would then make it easier for doctors to write more scripts for it (and do thinks like write refills and phone-in scripts...things you can't do with regular Schedule II stimulants)

 

[seep]

Could you potentially do it with any amino acid, or does it have to fit a certain profile?

I don't know what coupling it with other amino acids will do cuz the activation rate corresponds to the kinetics of each protease enzyme. Some of the amino acids found in archaic prokaryotes (or even some of those found in outer space) might not be active at all.

I don't understand why Vyvanse doses are almost double/triple dexedrine doses enough though Vyvanse is supposedly 100% bioavailable.

Maybe it has something to do with lisdexamfetamine having twice the molar mass of amphetamine?

 

[Temeraroius]

I would love to candy-flip on some MDMA XR and some LSD.

 

[seep]

An N-methamphetamine or N-ecstasy amide would get scheduled real fast I think.

 

[k4rnage]

A smooth MDMA for 8-10 hours sounds good to me. Though those could be made the same way Adderall XR are made, the high would probably not be quite as smooth as lysine or w/e amino acid binded to MDMA, considering many people are preffering vyvanse over adderall xr or dex sr because it's 'smoother'. MDMA can be pretty pushy sometimes but it sounds like that could be fixed this way if it works anything like lysdexamphetamine.

 

[pofacedhoe]

yeah but the come up has to be juicy and if it took ages that would make the high less rewarding. coming up is half of the fun of mdma and if it was slowly taking effect coming up might not be so pleasureable

 

[Symposion]

An N-methamphetamine or N-ecstasy amide would get scheduled real fast I think.

I totally agree with that.
They have no chance at all under such those analogue laws, even it would be a problem as long as you'd have to go through MDMA (or any other desired) to get MDMA+lisine or any other compound that convert the first drug in a pro-drug thanks to the metabolism of each subject.

Wasn't something alike in the case of the ALD-52 and the trial about it, where the cookers were convicted because the synth route HAD TO go through LSD, that was illegal substance to cook or posses by itself?

 

[Colmes]

I find it interesting because it's so bioavailable, though I don't understand why Vyvanse doses are almost double/triple dexedrine doses enough though Vyvanse is supposedly 100% bioavailable.

This is my guess.

Vyvanse comes in doses in increments of 10 - up to 70 now, I believe? Dex"SR" comes in 10, 15. I believe doctors, overtime saw that even sustained release dextroamphetamine lasted at the most, 4 hours, hence it being replaced largely by adderall which claimed to be longer lasting and steady, as far as the effects.

Vyvanse claims to have a therapeutic value for 12 hours (forgive me if i'm off, I didnt do any research prior to this post).

Now to bring up an example, the methylphenidate ADHD patch, "Daytrana", which advertises having a duration of 9 hours, actually contains...if I recall...something like 27.5mg of ritalin in a patch advertised as 10mg. The numbers may be off, I couldn't find a direct source, but I know the patch contains considerably more than the "dosage".

My point is, 12 hours is really from waking up till rest, so perhaps they have to increase the amount of dexedrine so it slowly and evenly is broken down and used by your body. There is a huge discrepancy in the duration of vyvanse and dexedrine SR.


This is what I believe, anyways.