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Lysergamides Lsd didnt work and i dont know why

C

Crazypumpkins

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Joined
Feb 16, 2025
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Hey everyone. I have a good batch of acid and I just dosed 400u last night after tripping off of 5g of shrooms the week before. I didn't feel a thing. I'm worried it might be tolerance but I only did some 2cb earlier and I heard that tolerance works differently with that compound....and that if you take it before an acid trip you will be fine. In any case it felt like I waited the whole day for fireworks that never came and now I'm all bummed because I reset my tolerance for nothing. What went wrong? And what should I do to make sure my trips are good in the future?

Thanks for your help
 
so at this point you are doing polydrug experiments.
try to do nothing all week and then lsd again next weekend without anything else in your system - please do report your findings,
 
Crazypumpkins said:
Hey everyone. I have a good batch of acid and I just dosed 400u last night after tripping off of 5g of shrooms the week before. I didn't feel a thing. I'm worried it might be tolerance but I only did some 2cb earlier and I heard that tolerance works differently with that compound....and that if you take it before an acid trip you will be fine. In any case it felt like I waited the whole day for fireworks that never came and now I'm all bummed because I reset my tolerance for nothing. What went wrong? And what should I do to make sure my trips are good in the future?

Thanks for your help
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Afaik there is minimal 2cb tolerance from reports, not personal experience never tested too building w b but I did w 25i and that def takes 1-2 weeks.

There may be a tolerance from 2cb to LSD though idk its complicated. So many serotonergics in a short time span I'm not surprised you didn't feel much
 
2C-B definitely has a cross-tolerance with acid, so that might be why your trip didn't kick in.
To make sure your trips are good in the future, I'd suggest waiting at least two weeks between trips to let your tolerance reset. Also, try to avoid mixing different psychedelics too close together.
 
Crazypumpkins said:
Hey everyone. I have a good batch of acid and I just dosed 400u last night after tripping off of 5g of shrooms the week before. I didn't feel a thing. I'm worried it might be tolerance but I only did some 2cb earlier and I heard that tolerance works differently with that compound....and that if you take it before an acid trip you will be fine. In any case it felt like I waited the whole day for fireworks that never came and now I'm all bummed because I reset my tolerance for nothing. What went wrong? And what should I do to make sure my trips are good in the future?

Thanks for your help
Click to expand...
I think it was probably just weak acid and/or you needed more.
 
Thanks for the advice, everyone. I definitely didn't know 2cb has cross tolerance with lsd. Ill wait for next Friday (perhaps saturday), try again and report back my findings! I have tripped hard on this batch before so I know that it is good. I'll avoid going for too many kinds of psychs at once. If nothing happens again ill wait the 2 weeks. :)
 
Crazypumpkins said:
Thanks for the advice, everyone. I definitely didn't know 2cb has cross tolerance with lsd. Ill wait for next Friday (perhaps saturday), try again and report back my findings! I have tripped hard on this batch before so I know that it is good. I'll avoid going for too many kinds of psychs at once. If nothing happens again ill wait the 2 weeks. :)
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Maybe you got a tab that didn’t have anything on it? I don’t think 2CB cross tolerance would result in literally no effects at all. How much 2CB were you using?
 
I need to look back through my notes but I've tested in 10+ people with some placebo/nocebo bait thrown in to see if 2C-B created tolerance to any of a variety of psychedelics, and it didn't in any cases.

I'm suspecting that this good batch of acid OP mentioned was just highly irregularly dosed, @Crazypumpkins have you reagent tested small cuts of a tab? You can verify it at least contains an indole group pretty easily that way. I've had sheets I thought were amazing before, only to find that they hit so well bc all of the acid is in half of the sheet essentially.

Edit: Allylescaline, DMT, harmaline, salvia, and 2C-B have all succeeded in producing no noticeable tolerance. While that's to be expected from things like salvia or harmaline, with the others it's pretty befuddling. Why allylescaline but not mescaline? Why 2C-B but not 2C-E? I'm not sure but hope to know at some point.
 
Regarding 2cb I was boofing pretty heavily. I would say I did at least 2 hits within a 12 hour period pretty near to when I decided to dose the acid. I did one 60mg boof and one 30 mg boof later on.

I haven't reagent tested this particular batch bc I tested the one I got before from this person and it was fine. So I suppose the tabs could theoretically have been weak, but after taking 4 x 100u tabs i took another 3 after a few hours after feeling nothing but a slight tingly feeling. I know there was definitely acid on there....I can tell from the feeling I got. However the fireworks never started...I just felt a bit tingly and lightheaded as I mentioned before.

I have a stronger batch of acid from another reliable vendor that I was planning on saving until the 100u blotters were done but maybe next time I should use those as a test next week.

So 2cb does not cause any cross tolerance whatsoever?
 
Crazypumpkins said:
Regarding 2cb I was boofing pretty heavily. I would say I did at least 2 hits within a 12 hour period pretty near to when I decided to dose the acid. I did one 60mg boof and one 30 mg boof later on.
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Have only dosed intranasally and orally, but was this 30+60mg in powder? 60mg of purified 2C-B has been enough to knock people out on occasion, just from how intense it is. For me it covers my entire field of vision in snakeskin fractals and visions of my future, personally.

Were you using pressed pills for this? If so, I'd consider reagent testing those, just to see if there's another, more tolerance-inducing drug in there.
 
Crazypumpkins said:
Regarding 2cb I was boofing pretty heavily. I would say I did at least 2 hits within a 12 hour period pretty near to when I decided to dose the acid. I did one 60mg boof and one 30 mg boof later on.

I haven't reagent tested this particular batch bc I tested the one I got before from this person and it was fine. So I suppose the tabs could theoretically have been weak, but after taking 4 x 100u tabs i took another 3 after a few hours after feeling nothing but a slight tingly feeling. I know there was definitely acid on there....I can tell from the feeling I got. However the fireworks never started...I just felt a bit tingly and lightheaded as I mentioned before.

I have a stronger batch of acid from another reliable vendor that I was planning on saving until the 100u blotters were done but maybe next time I should use those as a test next week.

So 2cb does not cause any cross tolerance whatsoever?
Click to expand...
That’s not THAT much 2CB. Definitely think this batch is way weaker or a different drug, possibly. Very easy to keep using the same sheets of paper but just not put any drug on it or use a different one.
 
Oh no I don't trust pressed pills. I got the powdered version of the 2cb. When I take it it definitely is enough to put me into another headspace but the visuals are definitely not as strong as what yours sound like. I'm jealous :)

I take some blood pressure meds and I am titration off of methadone so I'm also wondering if that has anything to do with why I am not experiencing the visuals and trips that I am supposed to. It seems like dmt is the only real thing that gets me seeing super strong visuals....this acid trip didn't, and neither did boofing 2cb powder (which i reagent tested). I really want to experience more out of my trips considering I can only do them once every one or two weeks, you know?

Like right now for instance, it feels like I am coming off of a strong psych dose so I KNOW I took a serious dose of something real. I just can't understand why it seems like I'm not tripping. Perhaps my brain is just resistant to it? But I highly doubt that...

Also, that time i took 5g of mushrooms ( a week before I dosed acid) it was in chocolate form. It took much longer than expected for me to start feeling things. But around 5 hours after eating the bar it DEFINITELY hit without question. My vision sharpened and music never sounded so amazing. I remember I laid on my bed closed my eyes and just listened to prog rock until the come up. But other than that trip and dmt, like I said before, its nothing much and its really puzzling. I gave my friend some of my 2cb and it knocked him off his ass. I wish these trips would be as strong for me though! Lol
 
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Crazypumpkins said:
I really want to experience more out of my trips considering I can only do them once every one or two weeks, you know?
Click to expand...
It sounds weird to say, but even working with product straight from the flask I've sometimes had acid just hang around at a distance like this, even dosing between 1.5-3mg (not ug). Weekly dosing of LSD will eventually accumulate a tolerance that requires a two week break ime, it seems like really the tolerance probably lasts ~10 days so us weekend warriors only giving it 7 days are accumulating tiny slivers of tolerance here and there, eventually adding up into something noticeable after a while.

To get more out of tripping, pay attention to your setting and consider new ones, or new activities. I have a bunch of books on my reading list but I'll still revisit old favorites when tripping just for the new perspective, I'll look back through old code I've written or music I've produced and it hits me as if it's brand new. The "reperspectivization" or whatever it would be called is the true value of psychedelics imo, and I've found that visuals are often contingent upon this. Attending a minor league baseball game on 6 tabs to see my best friend throw the opening pitch was fun, missed the pitch but it was still fun watching the multicolored particles fly out of the impact every time the ball met the bat. I was experiencing few to no visuals until that impact, ~4 hours after dosing, I just needed that environmental spark from the setting half of set&setting to really get things going.

Sometimes I've found that specific thoughts can enhance visuals, but some people are also notoriously "visual-resistant" in my personal experience of using and administering psychedelics. Those people often can only experience visuals from vaporized DMT, or shockingly high doses of orally administered psychedelics. Weird question, but do you happen to own a kaleidoscope you may be able to use to kick up the visuals? It always works well for me.

Also, what are the medications that you're on? Any that downmodulate serotonin?
 
Nope I don't have a kaleidoscope but that sounds like a novel idea! As far as meds are concerned I take Adderall daily, lisinopril, 1 klonopin for sleep nightly, metformin, meloxicam, and atorvastatin. I don't believe that any down modulate serotonin. I used to take abilify but I don't think that medication worked in that way either.
 
yeah 2c-B - LSD tolerance... 3 days at festival ~30-50mg 2c-b thruout and fourth day ~120µ LSD did nothing
 
Wow thats really surprising to me that 2cb affects tolerance for lsd...but it makes a lot of sense why I didn't feel anything. Strange thing is that the other day when I took 5g of mushrooms I did 2cb the day before and I felt that...though the effects of the mushrooms were probably muted a bit. Just goes to show how unpredictable the cross effects can be for psychedelics. I actually was looking into good kaleidoscopes on Amazon now because it sounds like an interesting idea to start visuals
 
fairnymph said:
Maybe you got a tab that didn’t have anything on it? I don’t think 2CB cross tolerance would result in literally no effects at all. How much 2CB were you using?
Click to expand...
In my experience (at least 10-20 times), LSD before 2C-B renders it almost completely inactive. The other way around, it's less obvious but definitely exist. But tolerance from 2C-B is tricky. More or less resets after 3-4 days. But IME sometimes less effect like 3 days after than the day after. Tolerance for visuals definately develops if used to often, but not to its general psychedelic effects or tactile effects.
 
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