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LSD and vitamin C, ive found my source, look.

SirLSD

Ex-Bluelighter
Joined
Feb 14, 2001
Messages
192
well, heres the source for those that didnt believe me and suggested that i was a kid believeing shit that my friends say.
A Hoffer, H Osmond. THE HALLUCINOGENS. Academic Press INC. 111 fith ave new york 10003, 1967. fifth printing 1972. pg 209.
its not a bad read. some of the theorys on mechinisms of action arent fully developed though, but we dont fully understand them today anyway. so a good book for its age. the finding are accurate though. theres 153 pages on LSD. plus good info on all the other hallucinogens including adrenochrome and other interesting stuff
smile.gif

anyway..... page 209 under the heeading of modifiers of the LSD experience. QUOTE "Ascorbic acid. Hoffer(1959) pretreated a few subjects with 4 grams of ascorbic acid each day for several days, then gave them LSD. Other subjects were given ascorbic acid at the height of the experience. This vitamin did not change the intensity of the experience but it did alter its quality. there was no decrease in the intensity of perceptual changes. the subjects were able to concentrate better and developed less paranoia. twenty-four hours later subjects who had been give ascorbic acid were not as tired as the controls" END QUOTE.
so hopefully ive gained a tiny grain of respect from those who didnt believe me.
btw, for the record, im currently doing me degree in pharmacy.
 
/action slaps SirLSD a high-five!
With a nick such as yours I would hope you were right!
Although I must admit I thought vit c enhanced effects.. not mellowed them..
 
1: J Pharm Pharmacol 1985 Dec;37(12):930-1
Ascorbic acid antagonizes the behavioural effects of LSD in cats.
Trulson ME, Crisp T, Henderson LJ.
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural
effects of lysergic acid diethylamide (LSD) and apomorphine, but not
5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that
these behavioural effects in cats are due to drug action at both 5-HT and
dopamine receptors, and that the action of LSD at dopamine receptors is
modulated by ascorbic acid.
 
Pretreatment with 5-HTP appears to lessen slightly the effects of LSD on some symptom rating scale, but the actual test subjects could not distinguish between placebo plus LSD and 5-HTP plus LSD. Unfortunately I don't remember the 5-HTP dosage used in these studies (I think it was quite small).
 
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