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LSD (and other 5HT2a agonist) and inflammation?

poneelovesyou

Greenlighter
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Sep 26, 2014
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So, as far as I'm aware, there have been no studies done looking at the effect of LSD (or other 5th2a psychedelics) on inflammatory or pro-cytokine pathways. Does anyone else feel intuitively that this should be studied? Maybe these drugs are indeed just increasing pain tolerance through increase of serotonergic activity. And probably addressing depression/anxiety (also usually related to inflammation/neurodegeneration) through upregulation of BDNF->neurogenesis. But It seems like mayyybe there's something going on that is regulating inflammatory response. Maybe it's just recalibrating glutamate activity and preventing oxidative stress/inflammation from excitotoxicity? Does anyone else think this concept merits further study, or am I just crazy? Or both?!
 
I thought it was well established that DOI was an anti-inflammatory at sub psychedelic doses... something to do with TNF-A?
 
The study sekio alludes to looked at other psychedelics too, including LSD, and although DOI was by far the most potent, the others also worked.
 
Thats really interesting that you say that, because I was recently diagnosed with Celiac. I struggled with depression and anxiety my whole life until I experimentally went gluten-free. Now I only have issues with it when I accidentally ingest (gliadin type) gluten. I've pinpointed my depression/anxiety being an inflammation induced symptom, often accompanied by joint pain and fatigue. Psychedelics and being gluten-free have had the biggest impact on eradicating my depression/anxiety, so its REALLY interesting that there might be some gut connection from the psychedelics. Thanks for the posts guys!
 
That's interesting. DrGreenthumb on here had success with bk-2C-B in treating coeliac disease (Big and Dandy bk-2C-B thread).
 
I was suffering from chronic auto-immune inflammatory joint pain for years, particularly in my neck, shoulders & back, due to coeliac disease. I'd been gluten free for 4 months, it improved quite a lot over that time, but I guess I was looking at another 12+ months to regain full movement, it was still very stiff, as if my vertebrae were fused together. A light BK-2C-B trip took it away almost completely, I laid down, my back crunched & suddenly I could move it all freely. I had a few more trips, abused it for some weeks, almost totally got rid of any pain or stiffness, exercised & I've managed to keep the movement & lack of pain in my back as a lasting effect, my back is still healing, but at least it can really heal now. I wasn't expecting that effect, I've never had anything similar from any other psychedelic or any other kind of drug I've taken (not tried lsd since I started to have the pain), the sense of relief was orgasmic & it's been life changing. It's over a week since I last used it & my back is still great, feels totally cured so far. I didn't need high doses that caused an intense trip to get the effect either.

It turned off the lingering depression, lethargy & brain fog left over from coeliac off too, that was all I was looking for, it having such a dramatic effect on my back was a shock. The brain fog lifting felt like half of the left side of my brain turning back on, I have been able to think more logically & clearly since, beat my friend at chess for the first time ever, twice. Best feeling of relief ever. It was an intensely good feeling as all my symptoms seemed to lift in a few minutes, this was just a threshold dose.

Before that the only drugs I tried that gave some temporary relief from the pain were cannabis or diclofenac & I didn't want to take diclofenac all the time, that was just for if it got really bad. Codiene wouldn't touch it. Psilocybe mushrooms did nothing spectacular for it.

When I was part way through my 'treatment', 40mg 5-meo-dalt made it worse, brought it all back, temporarily while under the effect of the drug. Mushrooms didn't seem to do much either way.

So... maybe bk-2c-b, or possibly other 2C-x drugs should be investigated. I feel like it might be closer to treating the cause, maybe having immune system effects. I haven't picked up any colds or infections though. I've no idea how it works, I'd like to know, it was an amazing effect, but not all psychedelics produce this effect. It should really be investigated.

I combined it with noopept too, I've been dosing on that for a year (on a break from it now), it was already helping a little with the "brain fog", but nothing like the intense effect I got from bk-2c-b. It was possibly a combination effect of the two drugs, at least the mental effects. Noopept allegedly promotes BDNF, has glutamate activity, etc.

I was starting to feel much better anyway, my immune system's reaction to gluten was the cause of all my problems, if I don't eat gluten then I don't get any problems, but after discovering that & going gluten free I was looking at a 12-18 month recovery time for the longer term damage it'd caused.

Either that or I'm manic from doing too many bath salts, but I can't see how that would fix my back & I've never been bipolar, it was all just depression with coeliac. I just still feel ecstatic to feel so healthy again, compared to how I was.

I obviously can't recommend that other people self medicate with new research chemicals, I feel a bit reckless taking it myself, mainly ecstatic that I was so lucky to find something that worked, but still. I really think it needs some proper scientific medical research.

It did nothing for what I'd call normal kinds of pain that most people are going to get from injuries, etc, the things that opiates are good for, it seemed linked to autoimmune inflammatory joint pain & possibly other problems caused by autoimmune inflammation.

I am obviously not a real doctor, never studied anything medical, but somebody who is should study this effect.
 
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