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Loperamide - 2nd try - some potential

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malfunkshun

Bluelighter
Joined
Nov 4, 2003
Messages
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What with the recent talk about loperamide and its potential recreational use, I decided to give it a try. Although, I wasn't really counting on it to be valuable as a 'good time' drug, but more of somthing to help through withdrawals when and if they happen (I'm usually flirting with withdrawals so an easy remedy would be a godsend). So, yesterday, I took 12 2mg loperamide pills. Little light blue rectangular pills, I think they were generic. A total of 24mg. I didn't really feel anything from these, but it is possible that I didn't give them time enough to kick in because those WD's were starting to creep up and I went ahead and ate my last dose of pods. I did notice though that this morning I wasn't clogged up, even after doing a medium dose of pops on top of 24mg of loperamide.

Today, I decided to up the dose since I didn't have any trouble feeding the commode its morning breakfast. So, I took 15 pills, a total of 30 mg. I'm out of pods for now, so it's either these or nothing. So, on my way to work I start feeling that 'rubber leg' syndrome that comes with a low to medium dose of morphine. You know, that kind of hollow, weak feeling in the legs that I describe to myself as a dark gray color. I know that makes no sense but your mind has a way of visualizing things. As of now, it's been about two hours since I ate the pills, and what I'm feeling is definitely not a placebo, but a full blown, unadulturated opiate buzz. There is no euphoria, but the 'rubber leg' syndrom has increased and is now in my arms. Thats the way it usually progresses for me, it starts in my legs and if I have dosed enough, it will spread to my arms. More of the same, and I eventually achieve good ole euphoria.

My conclusion is that loperamide, in a high enough dose (for me anyway) definitely will induce opiate-like effects. The true test will be whether or not my WD's start up again today. Usually, with a dose that produces this level of intensity, I'm usually good for at least 24 hours before the WD's set in. So, if I'm just starting to feel them creep up tomorrow morning, then this test to me will be a success.

I am wary however of upping the dose too much more than what I have tried. I don't want to get clogged up, but I can only imagine that possibly 60 mg of loperamide might potentially give me a mild euphoria. I will definitely try this again soon if, like I said, the loperamide is successful at keeping my WD's at bay until tomorrow morning.
 
you can get it for way cheaper than that in the generic aisle at the grocery store.

anyway, its been 6 hours since i took the loperamide and the 'rubber leg' feeling is starting to wear off, but i am still feeling safely normal with no signs of withdrawal. normally i would have been starting to withdraw by now... as a matter of fact, when i take a small to medium dose, i can count on WD's starting within 24 hours. based on that, i should have woke up feeling slightly yucky, and usually by now, with no re-dose, i would be on the road to feeling even worse.

so, the loperamide, for now, is successfully keeping the wd's at bay, pretty much completely.
 
Thats a good thing to know, I wonder how much more constipated it makes a person compared to a high dose of normal opioids. Interesting experiment, thanks for sharing!

It would be good to know how long before the WDs start to kick in.
 
well i'm not a big on opiates but these experiments of yerz are confusing...why would u take a dose u know isn't active, u might aswell just take a 16th of a vicodin, it's cheaper probly and has the same amount of theraputic value as what yer doing
@the pharmacy 99 2mg loperamide generic is like $15, cimetidine $10, benadryl $2, u gotta take atleast 50 pills
 
whut? where did i say i was taking cimetidine or benadryl? thats a real head scratcher. :\

and what are you talking about, me taking a dose i know wasn't active? i already said that didn't let the original dose kick in because i ate those poppy pods. then i upped the dose on the next try, fruitcake. you must be really stoned. 8)

edit: and i guarantee you a 16th of a vicodin would NOT produce the opiate effects i got from 30 mg of loperamide. besides, if i had access to vicodin, why would i be taking loperamide :\
 
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dont get all defensive I'm just wondering why yer posting useless wastes of time?

+ I never said u took cimetidine or benadryl, but u should have atleast taken cimetidine to help stop the loperamide from being completely destroyed by yer enzymes

like I said b4(read the full post) u gotta take atleast 100mg loperamide for anything beneficial to occur

if theWDs are @bay using the dose u took then that's pretty amazing but i dont think it will last too long
 
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Is there a chance that there won't be a difference between a normal dose of loperimide and a high dose in an opiate tolerant individual as far as constipation goes? I mean the receptors in your bowel should be as tolerant as the rest of you. Maybe it won't make you that constipated if youve been using for a long time.

Or....

Maybe there are just a limited number of receptors in the gut to saturate and the rest will be safely excreted by the body.

Maybe these high doses won't have a negative effect on the bowel....
 
toxide said:
dont get all defensive I'm just wondering why yer posting useless wastes of time?
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i'm giving a trip report. thats what this forum is for, so that people can post their experiences. there, understand now? are we clear? do you need it spoonfed to you?

+ I never said u took cimetidine or benadryl, but u should have atleast taken cimetidine to help stop the loperamide from being completely destroyed by yer enzymes

like I said b4(read the full post) u gotta take atleast 100mg loperamide for anything beneficial to occur
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apparantly not. did you not read my trip report? i felt decided effects on 30 mg. no tagamet needed.

if theWDs are @bay using the dose u took then that's pretty amazing but i dont think it will last too long
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yeah, pretty amazing huh.

ok, with that out of the way, its the next day. i slept well last night but i did wake up pretty early with WD's starting to set in. its not severe yet (i've been up for 6 hours) and i feel just about like i would have if i had taken my normal WD coping dose yesterday (not a dose to get high, just one to keep WD's away).

so in my judgement, loperamide CAN be used as a tool to fight mild withdrawal, if taken in high enough doses. this is how it affects ME, and ME ALONE. this is MY TRIP REPORT, i don't expect ANYONE ELSE to get these same results. there, can we all be happy now? oh and by the way i fed the commode just fine this morning.

edit:
Kaleem said:
Is there a chance that there won't be a difference between a normal dose of loperimide and a high dose in an opiate tolerant individual as far as constipation goes? I mean the receptors in your bowel should be as tolerant as the rest of you. Maybe it won't make you that constipated if youve been using for a long time.
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i have thought the same thing, that taking a mega dose of lope might not be such a big deal, after all i'm taking mega doses of other opiates to get high. i'm so used to them now that i NEVER get clogged up anymore. the last time that happened was at least a year ago and it was after i had been off opiates for about 3 months.
 
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Anyone tried to insufflate it? Wikipedia says it might force it through the blood-brain barrier. Not that I want to use it solely just to boost effects of other opioids. What would be the dose? And you must be joking saying you took 100mg of it if 4mg makes me more constipated than 400mg i.m.

EDIT: Never mind, I found that someone tried insufflating it and nothing came out of it.
 
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it affects everyone differently. i've heard of people having some success snorting it. i've got a batch settling right now in a CAE and i'll try it and report back.
 
Did you get stomach cramps? When I tried it I took a total of 48mgs. The stomach pain was excruciating and not worth mild opiate effects. The only positive was that buzz lasted about 8 hours. It definately wasn't worth the pain though. In fact I'd rather break a bone and go to the E.R. to get some real painkillers than repeat that experience.
 
no, i didn't get any stomach cramps at all. it hardly affected me at all that way, i mean, i didn't get stopped up or anything.

here is my experience with snorting it:

i crushed up 100mg of loperamide pills and used 90% isopropyl alcohol for a cold alcohol extraction. i put the resulting extract in a pyrex dish on top of a pot of boiling water, it evaporated in about 15 minutes, leaving what looked like little waves of crystals arranged in a vague bullseye pattern, with what looked like some solid waxy stuff in the middle. probably left over filler.

so, i scraped up as much as i could and arranged two fat green lines. i snorted one line. at first i thought it went down ok, but then it started to burn like hell. VERY irritating. i didn't snort the other line. my nose hurt like a bitch for about 20 minutes. after that it was stopped up, swelled shut in the nostril i snorted with. it didn't drain very well. i don't know how much actually absorbed because a couple of hours later i blew my nose and honked out a big ole greenie, looked like it probably contained a lot of the powder.

i didn't feel a whole lot. i plugged the other line and didn't feel anything from that. so, i just ate about 30 mg of loperamide pills to aid with creeping WD's and i was ok.

so, for me, the snorting thing didn't work at all and was pretty painful and definitely not worth the trouble. if i'm gonna do this to help with WD's, about 30 mg eaten the old fashioned way is a pretty good help.

edit: i couldn't find the 100 count bottle anywhere (i ate the last of the one i had with my first experiment), so i bought a box of 72. it cost 16 bucks at the local drug store so it can be a little pricey, but since i'm not using it to get high, and it does help with WD's every once in a while, its worth it.
 
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^^^^hey man i got 2 200 count bottles for probably less than you paid for 72. I dont know if i am allowed to post the store i got them at, but pm me if you really want to know (huge wholesale chain). Any way can you compare the nose troubles to anything else you snorted?
 
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