Yea moderation. My case for example, in 2 years took about 250pills with some months taking 8 pills a week. Was times when I would consider 3 week breaks an accomplished goal. After all the abuse the onset of a psychotic disorder from taking cocaine when my serotonin levels where down the drain, left me with unbalanced levels of the two. Would deffinately suggest you take at the most once a month and thats alot to me now, I havent taken my much loved MDMA for 7 freaking months and will wait another year from now till I take another pill. Abuse will deffinatley fuck you up nicely(sarcasm) you WILL be in hell. As for long term, well if you dont get proper diet, etc, and u deplete your serotonin, thats when all the bad shit happens to you like it did to me.