Seroquel makes me crave carbohydrates. It's well known for weight increase not only for that but for how it affects your metabolism.
I found Seroquel really helped with sleep and mood, but doesn't help with drive. But taking Metformin 1gram with Seroquel before bed is proven to prevent negative metabolic issues. Unfortunately, anything that is an adrenal antagonist will mess with insulin - adrenalin actually controls insulin levels in your body. Adrenalin initiates glycolysis while insulin initiates glycogenesis. Metformin interferes with the glycolysis process enough, if you eat healthy and exercise, that excess glucose in the blood isn't store as fat.
I tend to advocate exercise and diet as the other problem I had after quitting methamphetamine was surprisingly high blood pressure that was not easily controlled. Lisinopril at high doses worked best, but Angiotensin blockers were mostly ineffective. I tried a few calcium channel blockers (these are the worst as your heart muscle works via an osmotic reaction transporting calcium out of your heart - so they directly interfere with the actual mode of operation of the heart), alpha and beta blockers, and while the ACE inhibitor cough is real, getting yourself up to running enough your body produces enough adrenalin naturally helped a lot. I didn't find it much different than days when I was younger and I'd go running after a night of drinking and smoking. Felt like death for the first 1/2 mile then felt fine.
That was another thing I liked about Seroquel, it is very effective at lowering blood pressure and heart rate. Benzos had no significant effect, even high doses, like 2mg of Xanax or 20mg of Valium.
Now for me, I was taking strictly oral black-market pills in the 30mg dosage. My daily dosage would range from 30mg per day to 90mg per day if I had projects that required not sleeping. I actually didn't find methamphetamine to be very fun (especially compared to cocaine or say, real MDMA), the place preference effect is real (though it made me AOK being chained to my desk working non-stop), and over 60mg per day, the raising of your basal body temperature was also real. It made me so singularly focused on work I literally stopped showering regularly, had to force myself to eat, but made a ton of money as my productivity soared. After 9 months, the vasoconstrictive effects and my lack of exercise caused issues like edema and poor circulation, which caused me to quit and experiment with the aforementioned cardiovascular drugs.
On the positive side, I could see how methamphetamine was the drug of choice for most of the past 120 years since amphetamine was discovered, and why Adderall was designed as it is. Methamphetamine initially for me had zero side effects. No anxiety, very positive mood for a few months, and huge increase in productivity, especially with statistical and mathematical models. Adderall, especially at 30mg, causes me to have massive panic attacks. I believe the levoamphetamine isomer is added specifically to prevent overamping on the stuff.
Bottom line - if you aren't working, or don't have a technical/scientific/math heavy finance job, just focus on your health and take any cardiovascular drugs you need. If you have the money, just eat fruit and salads - no one gets fat fruit or salad. You'll also find your mental acuity improves faster with exercise.
All of this is personal experience. There is so little medical research on methamphetamine withdrawal. Everything I read on PubMed was effectively useless. I even tried Provigil or a time and it caused my blood pressure and heart rate to SKYROCKET. Never tried Wellbutrin, the other common substitute. I believe that drug has weight loss properties, even though its mode of action still isn't understood. Amphetamine works because it is structurally similar to adrenalin (just look on Wikipedia and you can see for yourself - they are simple chemical structures versus say, cocaine that has a very high molar weight). I strongly suspect even moderate term use of any amphetamine suppresses your natural adrenalin production. The only healthy way to get that back on track is exercise.
