Lesser known alkaloids in p .somniferum

[MurphyClox]

1. About Apomorphine: As long as the dose is low enough to NOT male you vomit, there is recreational potential, especially as aphrodisiac.

2. Antitussive does not equal respiratory depression.

3. The greenish colour stems IMO from chlorophyll resp. chlorophyll degradation products. Yo CAN NOT derive the the content of the extract just by its colour, as all "interesting" alkaloids are colourless. If the felt effect is different, then I won't contradict.

PEACE! Murphy

 

[ebola?]

This all makes me wonder:

could one make a direct dopamine agonist with the selectivity to induce euphoria w/o nausea?

ebola

 

[MurphyClox]

I'm not sure, which dopamine-receptor is responsible for the main part of the euphoria, but at least I would leave the D2 untouched. Otherwise, puking would be your fate.
I'll look this up tomorrow! Too tired right now, sorry...

Edit: But in general: Yes, I think that should be possible!

 

[LuxEtVeritas]

i do not believe any credible papers show apomorphine present in Lotus or related plants -- aporphine, but not Apomorphine

also i note one paper noting aporphine is hydroxylated in vivo to apomorphine but this seems to lack credibility as well as i do not see that possible

 

[RoxiPoppyGirl]

Wow, this is great info. Thanks so much. I always wondered about the lesser alkaloids in my pods. I really want to do more reading up on them.

TY

RPG

 

[Ham-milton]

I'm not sure, which dopamine-receptor is responsible for the main part of the euphoria, but at least I would leave the D2 untouched. Otherwise, puking would be your fate.
I'll look this up tomorrow! Too tired right now, sorry...

Edit: But in general: Yes, I think that should be possible!

I'm pretty sure it's D1 primarily.

 

[MurphyClox]

Yo thx Hammilton, that will make further searching easier!!! Am I allowed to call this already "teamwork"?

 

[LuxEtVeritas]

I believe D1 and D2 may though 'synergize' for optimal effects of this nature, though D1 is primary