• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Lemontek - p-gp inhibitor

Is that because the actives aren't affected by pgp pumps or becuase the lemon juice isn't a potent enough inhibitor?
 
What do you suppose the P-GPs have to do with the psychoactivity of mushroom alkaloids in the first place? If you'd explain perhaps a part of your theory however remote then it is more subjective to scrutiny.

Also, I'd be more than happy to move this to ADD if that would be your choice. But we can also wait with that to try to get the attention of both groups of mutually exclusive BLers.
 
I suppose he is thinking that psilocin may be pumped back across the blood brain barrier out of the area you want it by p-gp pumps. Therefore by inhibiting these pumps a larger accumulation of psilocin is capable of building up within the brain. Correct? I'm not sure if psilocin would work as a substrate for this pump, doesn't seem to be similar in structure to most of the compounds that are affected by it. And if it were then wouldn't things like serotonin etc. be actively pumped out of the brain?

Though I'll admit that my knowledge on the subject is pretty (very) limited.
 
Last edited:
Ah I see your point, I also agree about it not seeming to be similar in structure to any of the listed substrates I was able to find earlier with limited effort. Perhaps there is something overlooked here but again: then I'd like to see an article or something that states that analogous compounds are transported by these proteins.

So right now far fetched is a bit of an understatement ;) but no offense, I appreciate tangent ideation.
 
Lemon juice is not a p-gp inhibitor. I say this for a few reasons.
1. Nobody's found that lemon juice is useful for potentiating things that are otherwise inactive due to P-GP (loperamide)
2. Doctors don't warn you against drinking lemon juice
3. Most lemons are not psychoactive
4. There's a good explanation to why the lemon tek does what it does already
 
sekio said:
3. Most lemons are not psychoactive
Click to expand...

lol

4. There's a good explanation to why the lemon tek does what it does already
Click to expand...

There are at least two, but I think I deluded myself a long time with one of them. Helping with absorption due to enhancing stomach acidity is probably not realistic after all. But in vitro dephosphorylation catalysis seems plausible considering 4-hydroxy tryptamines are famously fast-acting and often visually impressive. I guess because there are no fancy dynamics i.e. in vivo hydrolysis.
It's a shame there have been no relatively easy lab experiments using citrus juice acids and before-and-after analysis.
 
I appreciate your responses, and most of this stuff is over my head and I value your opinions more than my own.

But doctors didn't warn against GFJ for quite a long time, iirc.

And..

"Effects of Grapefruit Juice and
Orange Juice on the Intestinal Efflux
of P-Glycoprotein Substrates"

http://www.biochem.arizona.edu/clas...jects/462bhonors2004/caix/misc/tian et al.pdf

"CITRUS JUICES INHIBIT THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING
POLYPEPTIDE OATP-B"

http://dmd.aspetjournals.org/content/33/4/518.full.pdf

"Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit, and pummelo."

http://www.ncbi.nlm.nih.gov/pubmed/12636154
 
You must log in or register to reply here.
Top