Lefetamin looks just nice-curious what the primary amine does,heres old lit. on it and other der. (drunkeness,sign of some dissociation at these huge doses?:
Testing diphenylethylamine compounds for analgesic action. Dodds, E. C.; Lawson, W.; Simpson, S. A.; Williams, P. C. Journal of Physiology (Cambridge, United Kingdom) (1945), 104 47-51. CODEN: JPHYA7 ISSN: 0022-3751. Journal language unavailable. CAN 39:25928 AN 1945:25928 CAPLUS
Abstract
cf. C.A. 39, 755.6. No significant rise in the pain threshold to heat in man was produced by 22 mg. morphine-HCl or 200 mg. diphenylethylamine taken orally. The latter caused the subjective symptoms of mild drunkenness. Significant rises in the pain threshold to elec. stimuli in rats were produced by 5-20 mg./kg. of morphine, 50-100 mg./kg. of pethidine, but not by diphenylethylamine-HCl or related compds., by aspirin, or by antipyretic compds. of the phenetidine series.
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Morphinelike properties of diphenylethylamine and related compounds. Dodds, E. C.; Lawson, W.; Williams, P. C. Middlesex Hosp., London, Proc. Roy. Soc. (London) (1944), B132 119-32. Journal language unavailable. CAN 42:9104 AN 1948:9104 CAPLUS
Abstract
cf. C.A. 37, 5145.6. Compds. studied were: bis(p-methoxyphenyl)ethylamine, m. 103-4°, HCl salt prisms m. 210-12°; b-hydroxy-a, b-diphenylbutylamine, viscous liquid, HCl salt needles m. 215-17°; b-hydroxy-a, b-diphenylpropyldimethylamine, oil, HCl salt hexagonal plates m. 248-50°; b-hydroxy-a, b-diphenylbutyldimethylamine, oil, HCl salt m. 251-2°; a-(p-anisyl)-b-phenylethylamine, oil, HCl salt, needles m. 215-17°; a-(p-hydroxyphenyl)-b-phenylethylamine, gummy solid, HCl salt m. 194-5°; a-phenyl b-cyclohexylethylamine b12 162-4°, picrate m. 183-4°, HCl salt needles m. 280-2°; a-(p-anisyl)-b-cyclohexylethyl-amine b0.2 130-5°, HCl salt needles m. 246-8°; bhydroxy-a, b-diphenylpropylamine; a-aminobenzyl phenyl ketone; a-dimethylaminobenzyl phenyl ketone; a, b-diphenylethylamine; a, b-diphenylethylenediamine; b-hydroxy-a, b-diphenylethylamine; and a-cyclohexyl-b-phenylethylamine. Methods of prepn. are briefly described for the first 8 amines. The following properties of morphine are possessed in differing degrees by some or all of the compds.: capacity to depress the righting reflex in rats, to raise the blood sugar in rabbits, and to cause hyperexcitability, pupil dilation, and vomiting in cats. The last 5 compds. listed were tested clinically and found to have definite analgesic action. b-Hydroxy-a, b-diphenylethylamine was the most active; doses of 200-400 mg. given orally at 4-hr. intervals to cancer patients with intractable pain could replace morphine.
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Search for morphine substitutes. Dodds, E. C. Univ. London, British Medical Bulletin (1946), 4 88-91. CODEN: BMBUAQ ISSN: 0007-1420. Journal language unavailable. CAN 45:45044 AN 1951:45044 CAPLUS
Abstract
cf. C.A. 42, 2022f. 1,2-Diphenylethylamine (I) and 17 of its derivs. (C.A. 39, 755.6) were tested as morphine (II) substitutes. The synthetic compds. had less capacity than II for depressing the righting-reflex in rats, and there was no coherent relationship between chem. structure and pharmacol. activity. I had a marked capacity for raising the blood sugar in rabbits, but the doses required were larger than required of II, and 1-phenyl-2-cyclohexylethylamine, 1-(p-anisyl)-2-cyclohexylethylamine, and 1-cyclohexyl-2-phenyl-ethylamine were more active than I. 2-Hydroxy-1,2-diphenylethylamine was tried on 14 patients and gave complete relief of pain without undesirable side effects. The whole series of compds. only relieved pain associated with nerve pressure.
