Slow_Mobius
Bluelight Crew
It's all relative dose and BA. Also lower dissociation constants = higher affinity (mostly)
Have a question. I am trying to taper off my prescribed pain meds and eventually come off. Can I use Kratom in the morning/ afternoon and my opiates at night. I am new to Kratom so any advice would be appreciated.
Thanks
oxycodone has kappa opioid activity as well. long term use has been assoiciated with the development of hallucinations and psychotomimetic symptoms in some individuals; as the mu receptors downregulate, the kappa receptors become more active
I just read an article on a new supposedly non addictive opiate with euphoric effects that mitigate addiction due to the dual action at the mu and delta receptor... At least I think it was that. The compound was called UMB425. Can't wait until that hits the RC scene (hint hint)It does work, but do still expect some withdrawal symptoms. Kratom mainly works on the delta opioid receptors, and not the mu opioid receptors, which the pharmaceutical narcotics work on. Try to keep your dosages of the kratom high, because at high doses, it does exhibit some mu activity.
I just read an article on a new supposedly non addictive opiate with euphoric effects that mitigate addiction due to the dual action at the mu and delta receptor... At least I think it was that. The compound was called UMB425. Can't wait until that hits the RC scene (hint hint)
Man in the dark and others, usage of opiates can be used correctly and a person can totally have a normal life. We are here to educate and make sure that people are safe with them on there own and in combination with other drugs. Harm reduction first and formost.
Thats interesting. I didn't know that was associated with kappa axtivity
Kratom alkaloids primarily act on mu and kappa opioid receptors
http://www.ncbi.nlm.nih.gov/pubmed/18482427
Tramadol is a weak opioid so people have to relatively large doses. That's also the receptor activity for tramadol not the demethylated metabolite. It's just another example of a opioid with kappa activity. It probably make a little contribution, but adds analgesia to some effect
I doubt it. If the kappa opioid activity contributed slightly to the euphoria, it would also contribute other effects typical of agonism of this receptor: anxiety, depression, dysphoria, some mild pseudo-"psychotomimetic" symptoms (such as intense daydreaming with milde CEVs, intense nightmares, some mild visuals possibly - high agonism isn't necessarily required for these effects; if low agonism can cause analgesia, it can also precipitate other kappa effects.).
Just like hyrdroxyzine, which has D2 antagonism in the microM. And that doesn't contribute anything to clinical effects. It is only felt in overdoses.
https://www.thevespiary.org/rhodium...ppear-to-be-k-opiod-receptor-mediated6d99.pdf
Did you read this link?
It indicates that oxycodone has very potent kappa opioid agonism.