Paulination
Bluelighter
Hey guys i just wanted to say that ive started to update my thread about ketoconazole potentiation of suboxone i would like to keep updating it weekly but im busy so i might just be monthly, and its not just for ketoconazole anymore really. its everything that can potentiate suboxone and subutex, also i found a golden egg called DAMGO its an synthetic opiod peptide, its only in experimental studies right now but it has been shown to reverse tolerance to opiods .if you take it with your opiod of choice you would supposedly not develop a tolerance for quite some time. im not sure how long or how much you would need to take. But i truly believe that this could be our salvation for all opiod users out there
if your taking an SSRI with cimetidine then watch out. I was taking 10mg lexapro at the time of my cimetidine test. it didnt cause any noticeable effects except the euphoria was about 30% better. i was also tapering down my lexapro while taking the cimetidine cause i wanted to reduce my tolerance with dxm since taking dxm and lexapro can be bad(it has to be a super high dose most of the time but it has a happened a couple times) anyway i decided that i would get off cimetidine it for a couple days and I started to get flu like symptoms(depression,pain,drowsy,fatigue,etc... i then realized that cimitidine also potentiates lexapro to. because their both metabolized by the cyp34a enzyme , so when i stopped taking my cimetidine dose my lexapro dose was back to the minimal amount i was tapering down to. suffice to say it was a bad couple days. i dont know if youve had bad withdrawal from lexapro or SSRI's but theyre pretty bad, not as bad as painkiller withdrawal but similar in some ways.
yes cimetidine does have some potentiating effects DK but if your taking literally any other prescription medication than suboxone, i wouldnt reccomend taking it. unless you check to make sure theres no interactions with it. and besides i believe (this is from what ive read) that grape fruit juice is a little better than cimetidine. cimetidine and grapefruit juice both do the same thing anyways some people say cimetidine is stronger and others say grapefruit juice. ethier way it should help you take a smaller dose than before
im sorry I have not updated sooner but i have been busy
Last update 9/26/2010
[/B][/COLOR]
Hey guys i just wanted to say that ive started to update my thread about ketoconazole potentiation of suboxone i would like to keep updating it weekly but im busy so i might just be monthly, and its not just for ketoconazole anymore really. its everything that can potentiate suboxone and subutex, also i found a golden egg called DAMGO its an synthetic opiod peptide, its only in experimental studies right now but it has been shown to reverse tolerance to opiods .if you take it with your opiod of choice you would supposedly not develop a tolerance for quite some time. im not sure how long or how much you would need to take. But i truly believe that this could be our salvation for all opiod users out there
im sorry I have not updated sooner but i have been busy
]I must say from first hand experiences tho I believe benadryl has been the best potentiator in my case
I HAVE READ THAT KETOCONAZOLE CAN BE USED FOR POTENATION OF OTHER OPIATES ALTHOUGH I DONT HAVE TO MUCH INFO ON THIS. So be careful if trying this
WARNING ONE THING ABOUT SAINT JOHNS WART: I have read that Saint johns wart is a inducer of the CYP3A4 therefore it cause the drug to leave your body faster and thats not a good thing my friends atleast not in my book. some people say it gets you higher but I dont believe this. from what sources ive read it means you have to take a much higher dose because the drug is leaving your body alot faster.
Im glad I take suboxone with nalaxone beause even though the nalaxone isnt active I have heard that Nalaxone reduces tolerance see here.
An interesting approach is the combination of opiates with the opiate antagonists naloxone or naltrexone in miniscule amounts. The combination of less than 0.001% of what would be a normal dose of the antagonist with an opiate allows a far greater response ("at least 50%") to the opiate which in turn permits a much lower effective dose to be used. It is also said to prevent respiratory depression, tolerance and addiction. This approach has apparently been patented (Crain & Shen 1996) and is being commercially developed by Pain Therapeutics. [R.A.H. 2000; Crain & Shen 2000
found this on erowid, now i imagine us people that take suboxone probably get .001% lol maybe a little more maybe a little less, and its fascinating to think that nalaxone which makes you go into withdrawals if used in miniscule amounts can help with tolerance and addiction thats one of my reasons for staying on suboxone lol.
heres the link if you wanna read more about it
http://www.erowid.org/chemicals/opia...es_info3.shtml
I found this on the wikipedia page of saint johns wart under pharmacokinetic interactions
http://en.wikipedia.org/wiki/Saint_Johns_wart
Pharmacokinetic interactions
St John's wort has been shown to cause multiple drug interactions through induction of the cytochrome P450 enzyme CYP3A4, but also CYP2C9. This results in the increased metabolism of those drugs, resulting in decreased concentration and clinical effect. The principal constituents thought to be responsible are hyperforin and amentoflavone.
St. John's wort also has been shown to cause drug interactions through the induction of the P-glycoprotein (P-gp) efflux transporter. Increased P-gp expression results in decreased absorption and increased clearance of those drugs which leads to lower clinical concentrations and efficacy.[21]
but I dont think that any other antideppresants do this, I mean i dont think any SSRI's do this. I am not to sure about the other ones, just SSRI's , i am on 20 mg lexapro but have started reducing my dose because I wanna potentiate my suboxone with dxm again, after I read about the bad interactions with dxm and SSRI's I kicked myself for not finding this out sooner since I was mixing the two for over a year now. anyway No other antidepressants should effect the metabolism of suboxone, I am pretty sure about this because after reading about the problems with st johns wart(which i was taking for 2 months to pontentiate suboxone, or so I thought) I read up on interactions between SSRI's and suboxone and found that their was no interactions between the two, although i have heard of a slight increase in euphoria when mixed with lexapro. I have also heard that lexapro is the best SSRI when combined with suboxone atleast thats what the addiction psychiatrist said in a forum.
I will be editing this post daily to add more sources so you people dont yell at me
First I would just like to say I really enjoyed sixpointseven post on ethanolic sublingual bioavailability gain. Also everyones other posts on suboxone potenation and everything here. I have probably been stalking these forums for 3 years now never making a post or thread. but im high on mids and on 24mg subs ethanol oh and i really likes adding grapefruit juice to, I mean I thinks it helps but does it really inhibit the CYP 34A enzyme?any hoo swim also like capnheroin i think thats his name, sorry if i didnt get it right. anyhoo im jabbering. I hope im typing all this stuff alright Im not a pharmacist and even though I has spent a month on research it dosent mean all of this is true.
Ketoconazole has been shown to increase C max values and AUC values of Suboxone and for people who dont know C max is the maximum concentration I.E when you have the highest amount or the peak amount of the drug in your body and AUC or area under the curve is something like the time after dosing vs the time after blahblah something with the amount of time after plasma concentration. Anyway i have found so Many different medical articles that are all very reliable at least i think so.
Ketoconazole is a inhibitor of the CYP34A liver enzyme which means it slows down the metabolism of suboxone and most other drugs atleast opiate wise. which means more nice happy drugs in the body and not out your piss and shit ^_^.
they all state that adminstering 200-400mg Ketoconazole before or after suboxone. I think its before atleasts thats the way im going to do it. I have a couple sites where I am able to get ketoconazole. anyway I am just worried about the hepatoxicity (prolly spelled this wrong so tired) or in lamen terms liver damage. If anyone can find on how much 200 mg of ketoconaole with 16mg of sub let me know. Im not gonna try it until i know for sure it dosent cause damage. sixpointseven a lil help here
. anyway heres one article on it
I got it at Im sorry guys id post more but its 11 and im dead tired ill post more tommorow. I hope u guys dont already know this, but anyway guys goodnight.
1.
http://www.rxlist.com/suboxone-drug.htm
Drug-drug interactions
CYP3A4 Inhibitors and Inducers: A pharmacokinetic interaction study of ketoconazole (400 mg/day), a potent inhibitor of CYP 3A4, in 12 patients stabilized on SUBOXOME [8 mg (n=1} or 12 mg (n=5) or 16 mg (n=6)] resulted in increases in buprenorphine mean Cnm values (from 4.3 to 9.8,6.3 to 14.4 and 9.0 to 171) and mean AUC values (from 30.9 to 46.9,41.9 to 83.2 and 52.3 to 120) respectively. Subjects receiving SUButex or SUBOXONE should be closely monitored and may require dose-reduction if inhibitors of CYP 3A4 such as azole antifungal agents (e.g. ketoconazole), macrolide antibiotics (e.g., erythromycin) and HIV protease inhibitors (e.g. ritonavir, indinavir and saquinavir) are co-administered. The interaction of buprenorphine with CYP 3A4 inducers has not been investigated; therefore it is recommended that patients receiving SUBUTEX or SUBOXONE should be closely monitored if inducers of CYP 3A4 (e.g. phenobarbital, carbamazepine, phenytoin, rifampicin) are co-administered (SEE WARNINGS).
2.http://www.ncbi.nlm.nih.gov/pubmed/10755464
For this website you have to pay for the whole thing so I would just read the basic part. It explains very little about ketoconazole interaction but the interesting thing is that it explains how suboxone is a inhibitor of the CYP34A live enzyme!! This means that suboxone itself slows down the metabolism....of itself!!. So I would reccomend being careful if adding ketoconazole.
3. http://www.ocpinfo.com/Client/ocp/OCPHome.nsf/object/Buprenorphine_Article/$file/Buprenorphine.pdf
If you look under Drug interactions you will see that they talk about this a little bit saying the same thing about Ketoconazole. They talk about CYP3A4 and Ketoconazoles inhibiting effect on suboxone. Pretty much the same thing with all the others ive shown you. Most of these articles dont go into depth on Ketoconazole but some of them do.
4.
http://www.ncbi.nlm.nih.gov/pubmed/18381489
This one talks about the same stuff as the rest, I know most of these say the same thing, but thats why I wanna show them to you. so you know that it wasnt just one study. anyhoo ill probably have 14 more sites by the end of today so just keep checkin this thread if you have any intrest in this
5.
http://www.ncbi.nlm.nih.gov/pubmed/9180349
Just found this one it says that ketoconazole and nifedipine inhibited(slowed down metabolism or lamen terms: makes the drug stay in your body) buprenorphine by 70%!!! which is damn crazy in my book that means a 70% increase in buprenorphine potenation.
6.
http://195.62.199.219/pctsla/mtrac/ProductInfo/summaries/B/BUPRENORPHINE 2.pdf
This one is really good because it explains it in lamen terms about why inhibitors have a increased clinical effect for bupe and inducers have a reduced clinical effect
Buprenorphine is metabolised by CYP3A4, therefore it is
expected that inhibitors of this enzyme (eg ketoconazole)
will increase the levels of buprenorphine and inducers of
this enzyme (eg rifampicin) may reduce the levels of
buprenorphine.
Lol i still have about 6 more sites to post ill probably add some more in like an hour. getting kinda boring to just post links lol.
7.
http://www.suboxone.com/hcp/pharmacists/pdfs/PharmaBrochure.pdf
How is SUBOXONE metabolized?
Buprenorphine is metabolized by cytochrome P-450 3A4 isoenzymes. It is
important to carefully monitor patients who are taking medications that inhibit
or induce CYP-450 isoenzymes, and it may be necessary to adjust their dosages.
For example, increased buprenorphine concentration occurs when the drug is
coadministered with ketoconazole.
This paragraph above is in the link 7. Theirs 3 types of brochures ive found pharmacist,physician,patient. only the pharmacist brochure mentions this little paragraph on ketoconazole. all of these brochures are made by reckitt- benckiser company(this company manufactures all the suboxone and subutex we put in our body) Its funny but u wuld think the company would tell this to the physician well actually its not funny because they know if they told the doc this increases concentrations they would lose hella money for 90 8mg suboxone it costs 700$ without insurance, with insurance its about 60$ lol and thats for good coverage lets imagine for a second...that most drug addicts in America DONT have insurance I know its hard to fathom.....and lets imagine if doctors told their patients how Ketoconazole is able to turn a 8 mg pill into a 16 mg and a 16mg pill into a 38mg pill!! (these are true facts check out my first link. well that could very well drop reckitts asskiser stock by 2 points so lets just forget i said anything.
8.
http://www.ema.europa.eu/humandocs/PDFs/EPAR/suboxone/H-697-PI-en.pdf
CYP3A4 inhibitors: an interaction study of buprenorphine with ketoconazole (a potent inhibitorof CYP3A4) resulted in increased Cmax and AUC (area under the curve) of buprenorphine (approximately 70 % and 50 % respectively) and, to a lesser extent, of norbuprenorphine.
Patients receiving Suboxone should be closely monitored, and may require dose-reduction if combined with potent CYP3A4 inhibitors (e.g. protease inhibitors like ritonavir, nelfinavir or indinavir or azole antifungals such as ketoconazole or itraconazole).
The following medicines may increase the buprenorphine blood concentrations, so concomitant use of
these medicines together with Suboxone should be closely monitored and could require in some cases
a dose reduction by your doctor:anti-retrovirals (ritonavir, nelfinavir, indinavir),
ketoconazole
Itraconazole
Jesus CHRIST 50% increase of buprenorphine in your body and 70% increase in area under the curve(amount of time the drug was in your body I think)
ok so Ive decided to keep posting some more sites that ive found so here i go. as long as no more douches foul up this thread.this is updated on 9/26/2010
9.
http://www.clinchem.org/cgi/content/full/43/12/2292
this one is well...one of my favirotes it talks about the buprenorphine/ethanol mix and it also has a sweet ass graph of how the suboxone tablet and the suboxone/ethanol compare with each other if you cant find the graph its figure 6 on the link, that one will show the concentration of the two different solutions.
10.
http://cat.inist.fr/?aModele=afficheN&cpsidt=15628024
this one compares again the buprenorphine tablet and ethanol solution Lol this one is a kicker, it actually uses the scientific method and proves that the ethanol solution is better than the tablet form
11.
http://jpet.aspetjournals.org/content/317/2/858.full.pdf
This link is a very complicated scientific publication, it was hard for me to understand some of it. it talks about how effective each opiate is at touching the G receptors(the receptors that make you feel good on opiods) and how potent they are, i must say this is an advanced publication its scientific qaulity is amazing. their actually able to test how good an opiod is at reacting to your U opiod receptors. it shows buprenorphine in their to. now when you see buprenorphine at the bottom of the list for potency dont get dragged down like i did. it took me a minute to realize that buprenorphine was actually measured with some of best opiates on earth. it only further makes me believe that buprenorphine is one of the greatest opiods ever (atleast in my case). anyway this isnt even the best part about it though. what we really should be looking into is a new opiod called DAMGO. i have looked it up out of curiosity because of its relative potency on this medical journal. it actually has the potential to totally recede and reverse tolerance. fucking amazing. I have the links that state this but im tired right now so ill do it in a couple days hopefully.
if your taking an SSRI with cimetidine then watch out. I was taking 10mg lexapro at the time of my cimetidine test. it didnt cause any noticeable effects except the euphoria was about 30% better. i was also tapering down my lexapro while taking the cimetidine cause i wanted to reduce my tolerance with dxm since taking dxm and lexapro can be bad(it has to be a super high dose most of the time but it has a happened a couple times) anyway i decided that i would get off cimetidine it for a couple days and I started to get flu like symptoms(depression,pain,drowsy,fatigue,etc... i then realized that cimitidine also potentiates lexapro to. because their both metabolized by the cyp34a enzyme , so when i stopped taking my cimetidine dose my lexapro dose was back to the minimal amount i was tapering down to. suffice to say it was a bad couple days. i dont know if youve had bad withdrawal from lexapro or SSRI's but theyre pretty bad, not as bad as painkiller withdrawal but similar in some ways.
yes cimetidine does have some potentiating effects DK but if your taking literally any other prescription medication than suboxone, i wouldnt reccomend taking it. unless you check to make sure theres no interactions with it. and besides i believe (this is from what ive read) that grape fruit juice is a little better than cimetidine. cimetidine and grapefruit juice both do the same thing anyways some people say cimetidine is stronger and others say grapefruit juice. ethier way it should help you take a smaller dose than before
im sorry I have not updated sooner but i have been busy
Last update 9/26/2010
[/B][/COLOR]
Hey guys i just wanted to say that ive started to update my thread about ketoconazole potentiation of suboxone i would like to keep updating it weekly but im busy so i might just be monthly, and its not just for ketoconazole anymore really. its everything that can potentiate suboxone and subutex, also i found a golden egg called DAMGO its an synthetic opiod peptide, its only in experimental studies right now but it has been shown to reverse tolerance to opiods .if you take it with your opiod of choice you would supposedly not develop a tolerance for quite some time. im not sure how long or how much you would need to take. But i truly believe that this could be our salvation for all opiod users out there
im sorry I have not updated sooner but i have been busy
]I must say from first hand experiences tho I believe benadryl has been the best potentiator in my case
I HAVE READ THAT KETOCONAZOLE CAN BE USED FOR POTENATION OF OTHER OPIATES ALTHOUGH I DONT HAVE TO MUCH INFO ON THIS. So be careful if trying this
WARNING ONE THING ABOUT SAINT JOHNS WART: I have read that Saint johns wart is a inducer of the CYP3A4 therefore it cause the drug to leave your body faster and thats not a good thing my friends atleast not in my book. some people say it gets you higher but I dont believe this. from what sources ive read it means you have to take a much higher dose because the drug is leaving your body alot faster.
Im glad I take suboxone with nalaxone beause even though the nalaxone isnt active I have heard that Nalaxone reduces tolerance see here.
An interesting approach is the combination of opiates with the opiate antagonists naloxone or naltrexone in miniscule amounts. The combination of less than 0.001% of what would be a normal dose of the antagonist with an opiate allows a far greater response ("at least 50%") to the opiate which in turn permits a much lower effective dose to be used. It is also said to prevent respiratory depression, tolerance and addiction. This approach has apparently been patented (Crain & Shen 1996) and is being commercially developed by Pain Therapeutics. [R.A.H. 2000; Crain & Shen 2000
found this on erowid, now i imagine us people that take suboxone probably get .001% lol maybe a little more maybe a little less, and its fascinating to think that nalaxone which makes you go into withdrawals if used in miniscule amounts can help with tolerance and addiction thats one of my reasons for staying on suboxone lol.
heres the link if you wanna read more about it
http://www.erowid.org/chemicals/opia...es_info3.shtml
I found this on the wikipedia page of saint johns wart under pharmacokinetic interactions
http://en.wikipedia.org/wiki/Saint_Johns_wart
Pharmacokinetic interactions
St John's wort has been shown to cause multiple drug interactions through induction of the cytochrome P450 enzyme CYP3A4, but also CYP2C9. This results in the increased metabolism of those drugs, resulting in decreased concentration and clinical effect. The principal constituents thought to be responsible are hyperforin and amentoflavone.
St. John's wort also has been shown to cause drug interactions through the induction of the P-glycoprotein (P-gp) efflux transporter. Increased P-gp expression results in decreased absorption and increased clearance of those drugs which leads to lower clinical concentrations and efficacy.[21]
but I dont think that any other antideppresants do this, I mean i dont think any SSRI's do this. I am not to sure about the other ones, just SSRI's , i am on 20 mg lexapro but have started reducing my dose because I wanna potentiate my suboxone with dxm again, after I read about the bad interactions with dxm and SSRI's I kicked myself for not finding this out sooner since I was mixing the two for over a year now. anyway No other antidepressants should effect the metabolism of suboxone, I am pretty sure about this because after reading about the problems with st johns wart(which i was taking for 2 months to pontentiate suboxone, or so I thought) I read up on interactions between SSRI's and suboxone and found that their was no interactions between the two, although i have heard of a slight increase in euphoria when mixed with lexapro. I have also heard that lexapro is the best SSRI when combined with suboxone atleast thats what the addiction psychiatrist said in a forum.
I will be editing this post daily to add more sources so you people dont yell at me
First I would just like to say I really enjoyed sixpointseven post on ethanolic sublingual bioavailability gain. Also everyones other posts on suboxone potenation and everything here. I have probably been stalking these forums for 3 years now never making a post or thread. but im high on mids and on 24mg subs ethanol oh and i really likes adding grapefruit juice to, I mean I thinks it helps but does it really inhibit the CYP 34A enzyme?any hoo swim also like capnheroin i think thats his name, sorry if i didnt get it right. anyhoo im jabbering. I hope im typing all this stuff alright Im not a pharmacist and even though I has spent a month on research it dosent mean all of this is true.
Ketoconazole has been shown to increase C max values and AUC values of Suboxone and for people who dont know C max is the maximum concentration I.E when you have the highest amount or the peak amount of the drug in your body and AUC or area under the curve is something like the time after dosing vs the time after blahblah something with the amount of time after plasma concentration. Anyway i have found so Many different medical articles that are all very reliable at least i think so.
Ketoconazole is a inhibitor of the CYP34A liver enzyme which means it slows down the metabolism of suboxone and most other drugs atleast opiate wise. which means more nice happy drugs in the body and not out your piss and shit ^_^.
they all state that adminstering 200-400mg Ketoconazole before or after suboxone. I think its before atleasts thats the way im going to do it. I have a couple sites where I am able to get ketoconazole. anyway I am just worried about the hepatoxicity (prolly spelled this wrong so tired) or in lamen terms liver damage. If anyone can find on how much 200 mg of ketoconaole with 16mg of sub let me know. Im not gonna try it until i know for sure it dosent cause damage. sixpointseven a lil help here
. anyway heres one article on it I got it at Im sorry guys id post more but its 11 and im dead tired ill post more tommorow. I hope u guys dont already know this, but anyway guys goodnight.
1.
http://www.rxlist.com/suboxone-drug.htm
Drug-drug interactions
CYP3A4 Inhibitors and Inducers: A pharmacokinetic interaction study of ketoconazole (400 mg/day), a potent inhibitor of CYP 3A4, in 12 patients stabilized on SUBOXOME [8 mg (n=1} or 12 mg (n=5) or 16 mg (n=6)] resulted in increases in buprenorphine mean Cnm values (from 4.3 to 9.8,6.3 to 14.4 and 9.0 to 171) and mean AUC values (from 30.9 to 46.9,41.9 to 83.2 and 52.3 to 120) respectively. Subjects receiving SUButex or SUBOXONE should be closely monitored and may require dose-reduction if inhibitors of CYP 3A4 such as azole antifungal agents (e.g. ketoconazole), macrolide antibiotics (e.g., erythromycin) and HIV protease inhibitors (e.g. ritonavir, indinavir and saquinavir) are co-administered. The interaction of buprenorphine with CYP 3A4 inducers has not been investigated; therefore it is recommended that patients receiving SUBUTEX or SUBOXONE should be closely monitored if inducers of CYP 3A4 (e.g. phenobarbital, carbamazepine, phenytoin, rifampicin) are co-administered (SEE WARNINGS).
2.http://www.ncbi.nlm.nih.gov/pubmed/10755464
For this website you have to pay for the whole thing so I would just read the basic part. It explains very little about ketoconazole interaction but the interesting thing is that it explains how suboxone is a inhibitor of the CYP34A live enzyme!! This means that suboxone itself slows down the metabolism....of itself!!. So I would reccomend being careful if adding ketoconazole.
3. http://www.ocpinfo.com/Client/ocp/OCPHome.nsf/object/Buprenorphine_Article/$file/Buprenorphine.pdf
If you look under Drug interactions you will see that they talk about this a little bit saying the same thing about Ketoconazole. They talk about CYP3A4 and Ketoconazoles inhibiting effect on suboxone. Pretty much the same thing with all the others ive shown you. Most of these articles dont go into depth on Ketoconazole but some of them do.
4.
http://www.ncbi.nlm.nih.gov/pubmed/18381489
This one talks about the same stuff as the rest, I know most of these say the same thing, but thats why I wanna show them to you. so you know that it wasnt just one study. anyhoo ill probably have 14 more sites by the end of today so just keep checkin this thread if you have any intrest in this
5.
http://www.ncbi.nlm.nih.gov/pubmed/9180349
Just found this one it says that ketoconazole and nifedipine inhibited(slowed down metabolism or lamen terms: makes the drug stay in your body) buprenorphine by 70%!!! which is damn crazy in my book that means a 70% increase in buprenorphine potenation.
6.
http://195.62.199.219/pctsla/mtrac/ProductInfo/summaries/B/BUPRENORPHINE 2.pdf
This one is really good because it explains it in lamen terms about why inhibitors have a increased clinical effect for bupe and inducers have a reduced clinical effect
Buprenorphine is metabolised by CYP3A4, therefore it is
expected that inhibitors of this enzyme (eg ketoconazole)
will increase the levels of buprenorphine and inducers of
this enzyme (eg rifampicin) may reduce the levels of
buprenorphine.
Lol i still have about 6 more sites to post ill probably add some more in like an hour. getting kinda boring to just post links lol.
7.
http://www.suboxone.com/hcp/pharmacists/pdfs/PharmaBrochure.pdf
How is SUBOXONE metabolized?
Buprenorphine is metabolized by cytochrome P-450 3A4 isoenzymes. It is
important to carefully monitor patients who are taking medications that inhibit
or induce CYP-450 isoenzymes, and it may be necessary to adjust their dosages.
For example, increased buprenorphine concentration occurs when the drug is
coadministered with ketoconazole.
This paragraph above is in the link 7. Theirs 3 types of brochures ive found pharmacist,physician,patient. only the pharmacist brochure mentions this little paragraph on ketoconazole. all of these brochures are made by reckitt- benckiser company(this company manufactures all the suboxone and subutex we put in our body) Its funny but u wuld think the company would tell this to the physician well actually its not funny because they know if they told the doc this increases concentrations they would lose hella money for 90 8mg suboxone it costs 700$ without insurance, with insurance its about 60$ lol and thats for good coverage lets imagine for a second...that most drug addicts in America DONT have insurance I know its hard to fathom.....and lets imagine if doctors told their patients how Ketoconazole is able to turn a 8 mg pill into a 16 mg and a 16mg pill into a 38mg pill!! (these are true facts check out my first link. well that could very well drop reckitts asskiser stock by 2 points so lets just forget i said anything.
8.
http://www.ema.europa.eu/humandocs/PDFs/EPAR/suboxone/H-697-PI-en.pdf
CYP3A4 inhibitors: an interaction study of buprenorphine with ketoconazole (a potent inhibitorof CYP3A4) resulted in increased Cmax and AUC (area under the curve) of buprenorphine (approximately 70 % and 50 % respectively) and, to a lesser extent, of norbuprenorphine.
Patients receiving Suboxone should be closely monitored, and may require dose-reduction if combined with potent CYP3A4 inhibitors (e.g. protease inhibitors like ritonavir, nelfinavir or indinavir or azole antifungals such as ketoconazole or itraconazole).
The following medicines may increase the buprenorphine blood concentrations, so concomitant use of
these medicines together with Suboxone should be closely monitored and could require in some cases
a dose reduction by your doctor:anti-retrovirals (ritonavir, nelfinavir, indinavir),
ketoconazole
Itraconazole
Jesus CHRIST 50% increase of buprenorphine in your body and 70% increase in area under the curve(amount of time the drug was in your body I think)
ok so Ive decided to keep posting some more sites that ive found so here i go. as long as no more douches foul up this thread.this is updated on 9/26/2010
9.
http://www.clinchem.org/cgi/content/full/43/12/2292
this one is well...one of my favirotes it talks about the buprenorphine/ethanol mix and it also has a sweet ass graph of how the suboxone tablet and the suboxone/ethanol compare with each other if you cant find the graph its figure 6 on the link, that one will show the concentration of the two different solutions.
10.
http://cat.inist.fr/?aModele=afficheN&cpsidt=15628024
this one compares again the buprenorphine tablet and ethanol solution Lol this one is a kicker, it actually uses the scientific method and proves that the ethanol solution is better than the tablet form
11.
http://jpet.aspetjournals.org/content/317/2/858.full.pdf
This link is a very complicated scientific publication, it was hard for me to understand some of it. it talks about how effective each opiate is at touching the G receptors(the receptors that make you feel good on opiods) and how potent they are, i must say this is an advanced publication its scientific qaulity is amazing. their actually able to test how good an opiod is at reacting to your U opiod receptors. it shows buprenorphine in their to. now when you see buprenorphine at the bottom of the list for potency dont get dragged down like i did. it took me a minute to realize that buprenorphine was actually measured with some of best opiates on earth. it only further makes me believe that buprenorphine is one of the greatest opiods ever (atleast in my case). anyway this isnt even the best part about it though. what we really should be looking into is a new opiod called DAMGO. i have looked it up out of curiosity because of its relative potency on this medical journal. it actually has the potential to totally recede and reverse tolerance. fucking amazing. I have the links that state this but im tired right now so ill do it in a couple days hopefully.
Last edited:
well i guess the best one to get is this you can get 30 200 mg for 20 bucks 
I seem to be the exception, though. 