Ketamine salts solubility

[phenethylo J]

Black Rose

she'll take you into the darkness

 

[sekio]

Life & Death 1 for DOS... great game. You too can learn how to remove someone's appendix. You know, just in case. As I recall you are a GI doc, and you can diagnose gas, bacterial infections, kidney stones, arthritis, appendicitis, & aortic aneurysms (the latter two require surgery). There's different medical imaging tools to help, surgeries can have complications arise which you have to deal with (I still remember - lidocaine for PVC, atropine for bradycardia!), and you even manage your surgical staff, some of which don't get along together.

Or if you feel like it, you can be a maniac - diagnose the first person who you see with appendicitis, and as soon as you enter surgery start slicing them up sans anesthetique. The head of surgery doesn't like that. Another cool trick is putting someone with a pacemaker in an MRI (needless to say that would make a mess), or someone with shellfish (iodine) allergies in CT with iodinated contrast. Both end up killing the pt and you get a lecture.

(A confession: hemophobia runs on my father's side. I'm a little better than he is, but when I was a teen playing L&D1 - even though it's only 4-color CGA and PC speaker sounds - the first time I went to surgery, draped and anesthetized the poor bastard, incised across the lower right quadrant... saw the bleeders start... and almost passed out in my fucking chair. I got pretty tolerant to it, though, and soon enough I was fixing people's aortas.)

The sequel, "Life & Death 2: The Brain" was even more harrowing. This time you're a neurologist, and you have 256 colors instead of 4. You diagnose migraine headaches, drug addiction, hysterical paralysis, neuropathy, infarcts, and do 3 different brain surgeries - subdural hematoma, brain tumor resection, and aneurysm repair. Even though it's a simulation game, the latter two are about as difficult as you would expect brain surgery to be. As for drug addicts, part of the deal is you get patients who are supposedly addicted to morphine or cocaine - diagnosed when the only abnormality is fucked pupils. You also have a magical clipboard, one option being "prescribe codeine".

Doctor sekio says to his cocaine-addict patient, "you know what you need? some opioids to even the high out." Unfortunately if you go around Rx morphine for everything, the addicts end up dead and your boss gets pissed. You even get a scene of hospital staff eating pizza in the morgue and cracking jokes about your crap surgery ability.

Oh, and this time you can be a maniac by doing things like jabbing pins (used for pain perception testing) into your pt's eye, give them nitroprusside and dopamine and watch their BP go to 0, or (this is a good one) operate on the wrong side of the head...

Definitely part of what made me interested in medicine! I highly reccomend.

 

[Gaffy]

Guys seriously take these to STP first before committing to naming these unwanted children. Seriously

 

[sekio]

this is a thread for pointless molecular doodles not serious pharmacology

 

[sekio]

It does, for example, no good to offer an elegant, difficult and expensive process to an industrial manufacturing chemist, whose ideal is something to be carried out in a disused bathtub by a one-armed man who cannot read, the product being collected continuously through the drain hole in 100% purity and yield. - Sir John Cornforth, Chemistry in Britain, 1975, 432.

 

[Nagelfar]

Do those websites still exist that give you full access to DOI numbered articles?

 

[sekio]

Sci-Hub: removing barriers in the way of science

The first pirate website in the world to open mass and public access to tens of millions research papers

www.sci-hub.tw

 

[Nagelfar]

^that's the one I remember. Thanks sekio.

 

[Gaffy]

COC(=O)C(COC(=O)C1=CC=CC=C1)C1CCCN1C


BLÆZØCAÏNE

Blows all other "caïnes" in the wind

NC1CCCC1C1=CC=C(F)C=C1

FHEXINE

Burn like a Fenix in its bewitched cycle, Fhexine.

And now for the Fine hex

NC1CCCC1C1=CC=CC=C1

BILLIE

CN(C)C1CCCC1C1=CNC2=C1C=CC=C2

EILISH

Together they make a name, facing the bad guy, better stay tame..

O=C1COCC2(CCN(CCC3=CC=CC=C3)CC2)N1C1=CC=CC=C1

MORPHENTANYL

Morpheus's favorite hit, to escape the Matrix's git.

CCNC(C1CCCCC1)C(=O)C1=CC=CC=C1

CHINCHECK

CycloHexylEthylaminoPhenyl-1-One, CHEXEDRONE.

And its little brother

CCNC(C1CCCC1)C(=O)C1=CC=CC=C1

SYCHOPEP

SychloPentylEthylaminoPhenyl-1-One, PEPTEDRONE.

 

[sekio]

A little late night reading for the campfire.

https://www.researchgate.net/publication/232271307_A_difficult_case_Diagnosis_made_by_hallucinatory_voices

 

[Nagelfar]

^one time a voice told me where to find a old cellphone I had lost days previous in the bushes off a hill in a park by saying "hot" or "cold" and responded with "you're welcome" after I found it. No one was around. Leverich park in Vancouver WA. I was tweaking, take that subconsciously into account.

 

[Gaffy]

CC(N)CC1CCCCC1C1=CC=CC=C1

STRANDWEISER

Dans l'espoir d'étendues inexplorées..

SwissTargetPrediction

swisstargetprediction.ch

NC1C2CCCC2CC1C1=CC=CC=C1

BITTER PROFESSIONAL

Doctor, these drugs don'fvck me up.

SwissTargetPrediction

swisstargetprediction.ch

And for a little fun:

CC1CCCC1(N1CCCC1)C1=CC=CC=C1

IZNOGOOD

He'll be seen flying on his magic carpet..

SwissTargetPrediction

swisstargetprediction.ch

And probably my last for today:

COC(=O)C(C(C1CCCC1)N1CCCC1)C1=CC=CC=C1

DRESDEN

To come up with a funny little stim.

SwissTargetPrediction

swisstargetprediction.ch

 

[sekio]

wonder what the mechanism is for this

 

[polymath]

wonder what the mechanism is for this

There's something like that in the 'scheme 2' of this article, where ethylene glycol + ammonia turns into aziridine at high temperature:

http://nopr.niscair.res.in/bitstream/123456789/42197/1/IJCA%2030A%2812%29%201041-1043.pdf

The pdf may download slowly as it's on a site in India.

 

[Gaffy]

I can't get around it, could someone explain?

 

[S.J.B.]

wonder what the mechanism is for this

Looking at the original patent, it's at 175 C under hydrogen over nickel, so my guess is it's just hydrogenolysis of the C-O bond followed by dialkylation of ammonia.

 

[polymath]

Has anyone ever tried to get raw opium or some other plant material absorbed through the skin with DMSO and occlusion band? Does it still keep the allergenic biomacromolecules out while getting morphine and codeine absorbed? Transdermal dosing bypasses the first pass metabolism, so if you boil a poppy seed wash liquid down to dryness and then add DMSO, it could be of some use even if the seeds are so low on alkaloids that it wouldn't otherwise be worth it.

 

[S.J.B.]

I would be wary bypassing first-pass metabolism with any kind of unrefined biological mixture.

 

[polymath]

I would be wary bypassing first-pass metabolism with any kind of unrefined biological mixture.

That's what I thought, too. The linked article says that the bioavailability of transdermal morphine applied on de-epithelialized skin is 75%, or 4.5 times more than in tablet form. It takes about 10 hours for most of it to get absorbed, but probably less if there's some partly nonpolar solvent (even acetone or something like that) in the same mixture. Or is 'partly nonpolar' a proper name for something that is miscible with both water and oils?

Transdermal administration of morphine to healthy subjects - PMC

1. Twelve healthy subjects received 10 mg morphine HCl delivered transdermally from an occlusive reservoir applied to a small area of skin, painlessly de-epithelialised by vacuum suction. On a separate occasion, 10 mg morphine HCl was given as an ...

www.ncbi.nlm.nih.gov

1. Twelve healthy subjects received 10 mg morphine HCl delivered transdermally from an occlusive reservoir applied to a small area of skin, painlessly de-epithelialised by vacuum suction. On a separate occasion, 10 mg morphine HCl was given as an i.v. infusion over 20 min. 2. Venous blood samples were collected serially for 72 h and assayed for morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) by h.p.l.c. Pupil size, salivation, and central nervous effects (nausea, fatigue, headache, feeling of heaviness and dysphoria/euphoria) were also measured. 3. After transdermal application morphine was absorbed by a first-order process to produce relatively constant plasma drug concentrations over 11 h. The absolute bioavailability of transdermal morphine was 75% (65-85%; 95% CI). The plasma concentrations of both M6G and M3G were lower after transdermal administration than after i.v. infusion, and a considerable delay (of up to 1 h) was observed before the metabolites were detectable. AUC ratios for M3G and M6G relative to morphine were similar after both modes of administration. 4. Non-analgesic effects were less pronounced at the lower plasma drug and metabolite concentrations observed after transdermal delivery than after the i.v. infusion of morphine. 5. Transdermal administration of morphine warrants investigation as an alternative route of morphine delivery.

 

[Gaffy]

SPACELIFT

J'suis dans mon vaisseau mère..

SwissTargetPrediction

swisstargetprediction.ch

PRO LINDA

Roll into the abyss, on the bliss



PENTANYL

Like Fentylone, like Pentylone, Like Pentanyl, like Fentanyl.



STRANDWEISER the second



PIPE PILE

I'm standing next to a mountain, and I chop it down with my hand..