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Ketamine and HPPD

S

SugarFree88

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Joined
Apr 6, 2010
Messages
33
The current consensus for the theory of HPPD amongst the researchers at Harvard medical is that theres been a loss of 5-ht2a receptor subtypes on GABAergic inhibitory neurons. Normally, when serotonin binds to these GABAergc neurons, it releases GABA. GABA output=inhibition=calm.

I found this on this site and i thought about the fact that i got HPPD after a really deep, almost anaesthetic K-Hole.
Now i'm pretty sure that Ketamine does not bind 5-HT2A receptors while it's pretty sure that it someway has an activity on sigma 1 receptors.

So i'm wondering if what i've been through those months (hallucinations, CEVs, moving walls) was just because of sleep deprivation and all the weed i smoked before that K-Hole (but not during it anyway).

Sorry for my english, and, btw, i'm fine now. :)
 
girl, ur english is perfectly fine!

glad to hear you're better.
cannabis does not cause hppd, but if you where in the khole while incredibly sleep deprived this might have lent to it.

aside from that i have no idea
 
Sega420 said:
girl, ur english is perfectly fine!

glad to hear you're better.
cannabis does not cause hppd, but if you where in the khole while incredibly sleep deprived this might have lent to it.

aside from that i have no idea
Click to expand...

Hi man, how are you doing?
Thanks man, i'm still grateful for what you did, you know, without your help and the help of a few guys maybe now i'd be snorting heroin again. <3
Thanks (hug) (kiss) =D

Anyway, i've noticed that anytime i smoked a little amount of tobacco when i had that kind of HPPD, visual disappeared for a few minutes.
I'm 100% right and back in my normal consciousness now.

Fuck ketamine, back to the sacred herb. :)
 
smellytim said:
I have since reevaluated my stance on my HPPD as more of a case of post traumatic stress disorder, overactive hypochondriasis, and paying more attention to visual static.
Click to expand...

Damn fine intuition. ;)

I've been tripping a lot with lucy, shrooms and mescaline without getting any HPPD.
 
SugarFree88 said:
I've been tripping a lot with lucy, shrooms and mescaline without getting any HPPD.
Click to expand...

This is why I find HPPD to be a very vague, gray-area disorder. In my case, my frequent visual disturbances started after a long, high-dose LSD trip. On the other hand, I don't find it to worsen after using mushrooms, but I'll notice an increase in symptoms after using LSD, which is why I have taken a break from it.
 
I guess I would say I have mild HPPD, I have constant static but when I'm sober I can typically ignore it or just not notice. Smoking pot, doing K or MDMA/E all cause it to get worse.

Sometimes when it starts to get worse I just need to do some acid to chill it out :\
 
Sega420 said:
girl, ur english is perfectly fine!

glad to hear you're better.
cannabis does not cause hppd, but if you where in the khole while incredibly sleep deprived this might have lent to it.

aside from that i have no idea
Click to expand...

Uhh... Unless i got HPPD from only a handful of acid trips, none of which at high doses, then cannabis most certainly does cause it. At the very least it amplifies it immensly while high, and amplifies it slightly over time when sober. I have CEV's relatively frequently, and get OEV's no matter what if i smoke weed, and even while sober pretty often. However while sober it is much less intense, but still noticeable. Started probably a year and a half after i started smoking weed daily, during which time i tripped on acid < 5 times.
 
HPPD could be caused by synaptic remodelling via histone protein acetylation/methylation in the chromatin/dna double helix complex in neurons. This would essentially shut off OR turn on certain genes that encode proteins responsible for maintaining the working stature of certain receptors if there is significant excitation caused by external consumption of chemicals that are, in nature, very excitatory and uncouple the visual processing system in the brain's visual cortex. An easier way to think of this scenario, atleast in my opinion, is that its somewhat of a defense mechanism to shield sensitive neurons from excitotoxicity by shutting down receptors that are located on inhibitory interneurons. Epigenetics to sum it into one word.

A few neurons can project to thousands of others inside the visual cortex. It's a very sensitive part of brain, especially since it's part of the neocortex, the most recent evolutionary part of the human brain. I believe this is why psychedelic compounds are so powerful and such a vital defense mechanism in hallucinogenic plant/fungi species.
 
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