-
OD Moderators: Keif’ Richards | negrogesic
RCs Isopropylphenidate Mega-thread
- Thread starter Speecies
- Start date
Not a great start for a mega thread.
Isopropylphenidate is a purely functional stimulant. Its ok, but the lack of adrenergic push makes it pretty non-motivating.
Isopropylphenidate is a purely functional stimulant. Its ok, but the lack of adrenergic push makes it pretty non-motivating.
Dextro .45
Bluelighter
I started out on Isopropylphenidate, and enjoyed it at low functional dosing at work. I would dose 5mg capsules and take a few at work. Great functional Ritalin analog. I have a great patent report of it being studied as a replacement for Ritalin with an improved safety profile, longer duration of action, and less interaction with ethanol.
I was using it until I got a script for Rita, and never looked back lol
Rita plus ethanol is very euphoric and functional for me...zero crash or negative effects. I enjoy Methylphenidate WAY more than Vyvanse (Lisdexamfetamine) which gave me insane dry mouth, trouble sleeping due to looong action, and a few palpitations.
Methylphenidate IR all the way
Isopropylphenidate is a decent alternative. Way less recreational potential, but very functional and gentle (less NE action than MPH). I enjoyed IPH actually for sharpening your mind and energy at work. I also have 4F-MPH which I still never tried. I am content with my Methylphenidate.
MPH = Amazing euphoric stimulant (my DOC + ethanol)
IPH = great functional stimulant (slightly longer lasting & less NE action)
4F-MPH = 3x potency of MPH at dopamine transporter (never tried)
Still have lots of everything ....for a rainy day
I was using it until I got a script for Rita, and never looked back lol
Rita plus ethanol is very euphoric and functional for me...zero crash or negative effects. I enjoy Methylphenidate WAY more than Vyvanse (Lisdexamfetamine) which gave me insane dry mouth, trouble sleeping due to looong action, and a few palpitations.
Methylphenidate IR all the way
Isopropylphenidate is a decent alternative. Way less recreational potential, but very functional and gentle (less NE action than MPH). I enjoyed IPH actually for sharpening your mind and energy at work. I also have 4F-MPH which I still never tried. I am content with my Methylphenidate.
MPH = Amazing euphoric stimulant (my DOC + ethanol)
IPH = great functional stimulant (slightly longer lasting & less NE action)
4F-MPH = 3x potency of MPH at dopamine transporter (never tried)
Still have lots of everything ....for a rainy day
simstim
Bluelighter
- Joined
- Apr 20, 2021
- Messages
- 6,606
I just tried this for the first time a few days ago. It's way more potent than ethylphenidate.
If you try it READ the recommended doses. You do NOT want to over do it with this one. It's very potent.
It's not bad though.
I had about 22mg up the nose earlier and just redosed 18mg.
I probably won't redose again today. Too much DNRI is always very unpleasant.
If you try it READ the recommended doses. You do NOT want to over do it with this one. It's very potent.
It's not bad though.
I had about 22mg up the nose earlier and just redosed 18mg.
I probably won't redose again today. Too much DNRI is always very unpleasant.
simstim
Bluelighter
- Joined
- Apr 20, 2021
- Messages
- 6,606
For me, real ethylphenidate was very cocaine like. I got some other shit one time labeled as ethylphenidate that was obviously not. Some kind of shittier cathinone instead.
Isopropylphenidate is a bit different. Definitely could be used as a study aid. I've been using it as a pick me up boost with 25e-NBOH and 6-APB.
simstim
Bluelighter
- Joined
- Apr 20, 2021
- Messages
- 6,606
Yes this is normal with ADHD.
Yesterday and today I tried isopropylphenidate orally and I think I prefer it orally... I've tried 30mg. It's pretty stimulating at that dose.
How dose doing bumps compare to taking it orally? For now I've only done the later. It seems very functional to me.
simstim
Bluelighter
- Joined
- Apr 20, 2021
- Messages
- 6,606
I like to bump it up.
Jabberwocky
Frumious Bandersnatch
This was meh as a drug, but great as a medicine because lack of all euphoria and Rush. I tried to get a Rush, but didn't get one. I IV'd 20mg, them 40mg, then 60mg. No Rush, no euphoria, no motivation, minor comedown and anxiety, as all phenidates. Then next Time i only snorted it,it gave little energy and motivation, calmed me down. Not mentionable comedown versus methylphenidate which IS horrible.
Dextro .45
Bluelighter
It’s amazing how you can chance a molecule the slightest and it has such dramatic changes to the drugs MOA
Ephedrine ……to Desoxyephedrine HCL (Methedrine/Desoxyn) d-Methylamphetamine the most potent & pleasurable dopaminergic stimulant on earth
Methylphenidate (Ritalin) is one of the worlds most successful blockbuster drugs in pharmacological history…..that and Valium (Diazepam).
Methylphenidate analogs are vast….but there will always be just ONE Ritalin (Methylphenidate) …….fck Focalin lol
Isopropylphenidate IPH is/was actually being investigated as a safer alternative to Ritalin. It has identical DAT properties but only 1/3 the NET which has safer cardiovascular properties…..but NET is also essential
d-Ethylphenidate is the only analog that’s euphoric on par with Ritalin.
Even 4F-MPH (which has 3.33X more DAT than Ritalin) doesn’t have the reenforcing properties of Ritalin.
4-Methyl Methylphenidate is also very pleasurable apparently (never tired)
I have Ritalin (Methylphenidate) for 10-15 years now…..it’s absolutely Amazing ….best dopaminergic stimulant I’ve had a script for. Vyvanse (Lisdexamfetamine) was not great (pro-drug for d-Amph) tried Adderall XR 30mg capsules which were GREAT …..IR Dexedrine 5mg are gold standard SKF …..but I had an apo-tex 5mg which was pressed garbage most likely
Isopropylphenidate IPH is a functional dopaminergic stimulant at best……Ritalin without the euphoric pleasure lol
CIBA pharmaceuticals god bless that Italian pharmacologist who named his new compound after his lovely wife, Margarette (whom he called Rita) …. Ritalin was born. Methylphenidate 5/10/20 IR and a 100mg API powder for IV/IM/SC injection 10mg doses injected are like 100mg orally
Ephedrine ……to Desoxyephedrine HCL (Methedrine/Desoxyn) d-Methylamphetamine the most potent & pleasurable dopaminergic stimulant on earth
Methylphenidate (Ritalin) is one of the worlds most successful blockbuster drugs in pharmacological history…..that and Valium (Diazepam).
Methylphenidate analogs are vast….but there will always be just ONE Ritalin (Methylphenidate) …….fck Focalin lol
Isopropylphenidate IPH is/was actually being investigated as a safer alternative to Ritalin. It has identical DAT properties but only 1/3 the NET which has safer cardiovascular properties…..but NET is also essential
d-Ethylphenidate is the only analog that’s euphoric on par with Ritalin.
Even 4F-MPH (which has 3.33X more DAT than Ritalin) doesn’t have the reenforcing properties of Ritalin.
4-Methyl Methylphenidate is also very pleasurable apparently (never tired)
I have Ritalin (Methylphenidate) for 10-15 years now…..it’s absolutely Amazing ….best dopaminergic stimulant I’ve had a script for. Vyvanse (Lisdexamfetamine) was not great (pro-drug for d-Amph) tried Adderall XR 30mg capsules which were GREAT …..IR Dexedrine 5mg are gold standard SKF …..but I had an apo-tex 5mg which was pressed garbage most likely
Isopropylphenidate IPH is a functional dopaminergic stimulant at best……Ritalin without the euphoric pleasure lol
CIBA pharmaceuticals god bless that Italian pharmacologist who named his new compound after his lovely wife, Margarette (whom he called Rita) …. Ritalin was born. Methylphenidate 5/10/20 IR and a 100mg API powder for IV/IM/SC injection 10mg doses injected are like 100mg orally
Last edited:
Dextro .45
Bluelighter
Also a side note…Health Canada (although restricted all the MPH analogs about 7 or 8 years ago) specific analogs are still being actively researched as possibilities to be marketed as branded ADHD medications. The most prominent example being IPH - Isopropylphenidate HCL and to a lesser extent 4-Methyl-MPH and EPH - Ethylphenidate.
There are various medical journals outlining all three Phenidates / MPH - IPH - EPH for their pharmalogical profiles and binding affinities. Isopropylphenidate IPH is the most attractive candidate due to it minimal DDI’s, reduced issues with co-administration with ethanol/alcohol (like Ritalin has)
Most significantly, Isopropylphenidate has nearly identical binding affinity to the DAT but boasts an attractive safety profile of only 1/3 the affinity at the NET. Reduced Norepinephrine activity results in less severe cardiovascular affects such as increased HR & BP.
It should be noted however, Ritalin (Methylphenidate) although classified as a “Classic Amphetamine” is easily the safest dopaminergic stimulant ever marketed since the 1950’s . In safe, low, therapeutic doses, Ritalin (Methylphenidate) is a rapid acting mild stimulant & antidepressant, that has minimal adverse effects on reducing appetite and causing sleep disturbances
The ED-50 of Methylphenidate is 0.25mg of HCL salts / per Kg of body weight ….the Effective Dose to inhibit 50% of the DAT (ED-50). A short acting drug with a duration of acting 3-4 hours max. Taking Ritalin with a healthy fatty meal actually speeds absorption achieving higher C-Max…..more concerning, co-administering Ethanol with Methylphenidate significantly increases the active isomer, being d-threo-Methylphenidate HCL (marketed as Focalin currently)
I have large quantities of:
IPH - Isopropylphenidate
MPH - Methylphenidate (Ritalin)
4F-MPH - 4 Fluoromethylphenidate (has 3.33X higher affinity to the DAT) not euphoric oddly
Vyvanse (Lisdexamfetamine) pro-drug to d-Amphetamine 3h onset / 8-10h duration
Small amounts of Dexedrine Spansule & IR tablets
Honestly….. Ritalin (Methylphenidate) is the safest most pleasurable dopaminergic stimulant I’ve EVER has the pleasure of taking. Nearly identical euphoric bliss as oral Oxycodone. I’ve never felt so happy and content, euphoric, outgoing social butterfly, confident, bold, charismatic pleasant individual
20+ years ago when I was naive on every substance, I’d LOVE to have taken this oral Brompton Cocktail
as a 240 lbs / 6’ male I think I’d be able to enjoy this. Id be FREAKING FADED …but not dangerous
Oxy-IR 5mg tablets
Ritalin 20mg IR tablets
Xanax 1mg
Valium 10mg
Lyrica 150mg
Phenibut 750mg
Isopropylphenidate IPH is actually a great compound to add to the Ritalin (Methylphenidate) to increase the Dopamine while having minimal effects on Norepinephrine
There are various medical journals outlining all three Phenidates / MPH - IPH - EPH for their pharmalogical profiles and binding affinities. Isopropylphenidate IPH is the most attractive candidate due to it minimal DDI’s, reduced issues with co-administration with ethanol/alcohol (like Ritalin has)
Most significantly, Isopropylphenidate has nearly identical binding affinity to the DAT but boasts an attractive safety profile of only 1/3 the affinity at the NET. Reduced Norepinephrine activity results in less severe cardiovascular affects such as increased HR & BP.
It should be noted however, Ritalin (Methylphenidate) although classified as a “Classic Amphetamine” is easily the safest dopaminergic stimulant ever marketed since the 1950’s . In safe, low, therapeutic doses, Ritalin (Methylphenidate) is a rapid acting mild stimulant & antidepressant, that has minimal adverse effects on reducing appetite and causing sleep disturbances
The ED-50 of Methylphenidate is 0.25mg of HCL salts / per Kg of body weight ….the Effective Dose to inhibit 50% of the DAT (ED-50). A short acting drug with a duration of acting 3-4 hours max. Taking Ritalin with a healthy fatty meal actually speeds absorption achieving higher C-Max…..more concerning, co-administering Ethanol with Methylphenidate significantly increases the active isomer, being d-threo-Methylphenidate HCL (marketed as Focalin currently)
I have large quantities of:
IPH - Isopropylphenidate
MPH - Methylphenidate (Ritalin)
4F-MPH - 4 Fluoromethylphenidate (has 3.33X higher affinity to the DAT) not euphoric oddly
Vyvanse (Lisdexamfetamine) pro-drug to d-Amphetamine 3h onset / 8-10h duration
Small amounts of Dexedrine Spansule & IR tablets
Honestly….. Ritalin (Methylphenidate) is the safest most pleasurable dopaminergic stimulant I’ve EVER has the pleasure of taking. Nearly identical euphoric bliss as oral Oxycodone. I’ve never felt so happy and content, euphoric, outgoing social butterfly, confident, bold, charismatic pleasant individual
20+ years ago when I was naive on every substance, I’d LOVE to have taken this oral Brompton Cocktail
as a 240 lbs / 6’ male I think I’d be able to enjoy this. Id be FREAKING FADED …but not dangerous Oxy-IR 5mg tablets
Ritalin 20mg IR tablets
Xanax 1mg
Valium 10mg
Lyrica 150mg
Phenibut 750mg
Isopropylphenidate IPH is actually a great compound to add to the Ritalin (Methylphenidate) to increase the Dopamine while having minimal effects on Norepinephrine