Isodiazepam: naturally occurring, novel benzodiazepine

[Phener]

^^^
Right, but why just diazepam/nordiazepam then especially when one of these studies was conducted in 1989? I'm aware benzos are most prescribed class of psychoactive medicine (or at least were) but surely you would see all kinds of other things as well if it was simply an environmental pollutant. Pharmaceutical pollution surveys have detected dozens of drugs in drinking water internationally e.g. Bezafibrate, Bleomycin, Clofibric acid, Carbamazepine, Diclofenac, Gemfibrozil, Ibuprofen, Phenazone, Propylphenazone and Tylosin

Pharmaceuticals: a threat to drinking water?
Oliver A. Jones, John N. Lester and Nick Voulvoulis

Abstract

Aqueous acid extracts of wheat grains and potato exhibit after HPLC separation a series of compounds that are able to inhibit the binding of benzodiazepines to benzodiazepine receptors of rat brain membranes. In wheat one of the inhibiting compounds was shown to be identical to diazepam by means of HPLC characterization and gas chromatography combined with mass spectrometry. In potato one of the most prominent components in terms of binding inhibiting activity was identified as lormetazepam. In wheat and potato germination increases total inhibiting activity of the whole plant extracts as well as the content of the benzodiazepines approximately by factor five. Because uptake of benzodiazepines from the surrounding was excluded these findings indicate the biosynthesis of the benzodiazepines diazepam and lormetazepam by the plants investigated.

yet another KNOWN benzo. Indeed you probably would see all kinds of pharmaceuticals but these publications aren't EXCLUSIVE, they don't deny the existence of other pharmaceuticals - they merely provide evidence on compounds mentioned.

Regardless though convinced people are being too optimistic with this one, seen far too many biased so called "science" publications. These studies are EASY publications to whizz off and look good. Nanogramm quantity - VERY handy for justifying non replicability - the quintessential component of modern science.

 

[kaossalami]

http://www.sciencedirect.com/scienc...ab1bb5d0b171605b64c71d1b9970ac4b&searchtype=a