salvadorianstud
Greenlighter
- Joined
- Aug 4, 2016
- Messages
- 8
I blew about 6k in college financial aid on molly in under 3 months. And in my experience it's a waste of mdma. After a one time use your serotonin is pretty much nill.
Completely False - the synaptic vesicle is constantly being refilled with serotonin -- synthesis of serotonin never stops it may be reduced but it is still going on
nothing is ever 100% in biological systems. so while synthesis doesn't stop completely, mdma is a potent inhibitor of tryptophan hydroxylase leading to impaired synthesis of new serotonin.
besides, neurotransmitter depletion is a perfectly fine explanation for the tachyphylaxis we see with mdma. even for amphetamines this is the accepted model for tachyphylaxis. and the pathways using dopamine/noradrenalin seem more "more robust" than those using serotonin when confronted with chemicals.
here is just one random paper showing 5-ht depletion in rats. granted, the doses are higher than we'd see in humans (they try to find markers for decreased neuron viability using a ricaurte-style regimen but don't find anything to that effect), but what tells you that there is no depletion of serotonin at all even at lower doses when we know for sure that mdma releases shitloads of serotonin which is then broken down (because sert is blocked/reversed) and when we know that mdma inhibits serotonin synthesis?
both of the following are true
1. MDA is NOT cross tolerant with MDMA -- MDA effects are subjectively normal after 6 days of MDMA administration that resulted in complete tolerance to MDMA - PIHKAL -Shulgin
2. Tolerance to MDMA reverses after 7 days abstinence
so if serotonin synthesis is 90% inhibited -- that = 310 minutes, 480 minutes, for the putamen, and 8 minutes and 13 minutes for the temporal cortex -- to completely re-saturate the tissue (synaptic vesicle)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153986/ said:In the acute phase, which lasts for the first few h after drug administration, massive depletion of brain tissue 5-HT is accompanied by inactivation of tryptophan hydroxylase. By 24 h later, tissue 5-HT recovers to normal levels but hydroxylase activity remains diminished
i don't buy it that there's no cross tolernace with mda. mda hits the same receptors.
There is no basis to this statement at all. Is it advisable? Perhaps not
Is there any evidence at ALL that 3consecutive days of MDMA use is harmful? NONE WHATSOEVER
In fact, in PIHKAL Alexander Shulgin cites a tolerance study where subjects were given 120 mg - 160 mg MDMA daily for 6 days.
Unfounded Assertion, many people actually DO continue to feel the effects just fine
Completely False - the synaptic vesicle is constantly being refilled with serotonin -- synthesis of serotonin never stops it may be reduced but it is still going on
Total Bullshit -- how MDMA is metabolized has nothing to do with serotonin release -- the only difference in MDMA metabolism caused by MDMA use is the inhibition of CYP450 enzymes -- causing a longer but not different metabolic process
Again, total Bullshit
Posts like yours contribute to people NOT LISTENING TO HARM REDUCTION your are scientifically WRONG, and assert ridiculous things (nerve damage after 3 rolls - lolz lolz)
To the OP --
Based on many thousands of experiences, and outcomes the following is likely:
1. The subjective experience of MDMA -- for most people is reduced on consecutive days of use.
2. It is likely you will experience an altered perception, and perhaps a slightly depressed mood on day 4 -- however a small percentage of persons experience elevated mood as an afterglow for days or even weeks following MDMA use
3. Due to the catecholamine release and cascade as well as the possible inability to sleep -- it is very likely you will be physically exhausted on day four
If the substance you have is not MDMA or MDXX -- you could be subject to harm by taking an unknown substance for 3 consecutive days
the likelihood that you will have a negative experience and/or after effects increases based on the following:
1. concurrent use of alcohol
2. excessive concurrent use of cannabis (research cannabinoids like Spice/K2 should be avoided like the plague)
3. concurrent use of cocaine/ amphetamines/methamphetamines
4. failure to remaine properly hydrated with electrolytes (not dehydrated, not over hydrated on water alone)
5. failure to eat balanced meals
6. use of redosing MDMA or multiple dosing MDMA on any of the 3 consecutive days of use
That message is for icedcofee