SuperPsych
Bluelighter
- Joined
- Apr 29, 2012
- Messages
- 780
This is from Mirtazapines wiki page.
"There is a possible interaction that results in a hypertensive crisis when mirtazapine is given to a patient that has already been on steady doses of clonidine. This involves a subtle consideration, when patients have been on chronic therapy with clonidine and suddenly stop the dosing, a rapid hypertensive rebound sometimes (20%) occurs from increased sympathetic outflow. Clonidine's blood pressure lowering effects are due to stimulation of presynaptic α2 autoreceptors in the CNS which suppress sympathetic outflow. Mirtazapine itself blocks these same α2 autoreceptors, so the effect of adding mirtazapine to a patient stabilized on clonidine may precipitate withdrawal symptoms."
So it's my understanding that if someone who has been on clonidine for some time takes Mirtazapine, then it will precipitate WD. Similar to someone who has been on full opioid agonist for some time taking Narcan.
How about the other way around? I'm prescribed Mirtazapine and take it occasionally for sleep. If I have mirtazapine and take a clonidine, will there be any danger? I'm not prescribed clonidine and don't take it regularly, but I do occasionally like to take it occasionally to help get to sleep after dissociatives, psychedelics or stimulants.
I took 3-MeO-PCE tonight and I'd usually take mirtazapine to help me sleep, but im trying to take a break from Mirtazapine so that I can use a psychedelic in the next week or 2.
I greatly appreciate any help
"There is a possible interaction that results in a hypertensive crisis when mirtazapine is given to a patient that has already been on steady doses of clonidine. This involves a subtle consideration, when patients have been on chronic therapy with clonidine and suddenly stop the dosing, a rapid hypertensive rebound sometimes (20%) occurs from increased sympathetic outflow. Clonidine's blood pressure lowering effects are due to stimulation of presynaptic α2 autoreceptors in the CNS which suppress sympathetic outflow. Mirtazapine itself blocks these same α2 autoreceptors, so the effect of adding mirtazapine to a patient stabilized on clonidine may precipitate withdrawal symptoms."
So it's my understanding that if someone who has been on clonidine for some time takes Mirtazapine, then it will precipitate WD. Similar to someone who has been on full opioid agonist for some time taking Narcan.
How about the other way around? I'm prescribed Mirtazapine and take it occasionally for sleep. If I have mirtazapine and take a clonidine, will there be any danger? I'm not prescribed clonidine and don't take it regularly, but I do occasionally like to take it occasionally to help get to sleep after dissociatives, psychedelics or stimulants.
I took 3-MeO-PCE tonight and I'd usually take mirtazapine to help me sleep, but im trying to take a break from Mirtazapine so that I can use a psychedelic in the next week or 2.
I greatly appreciate any help
