N&PD Moderators: Skorpio | someguyontheinternet
BilZ0r said:^ Drugs don't need to be water soluble to be insuflated
BilZ0r said:No, you're both wrong. For one, benzos can be snorted. Secondly, ALL membranes can only be crossed by fat solubile drugs, unless there is an carrier/channel for it.
Read this post, and then get back to me.
By that I assume you mean, drugs with a lower o/w co-efficent are better absorbed. Well if this is such a basic physiologica fact, I'm sure you will have no problem finding an authoratative citation or two to support you.But, it's just basic physiology that a water soluble drug will be much more likely to be absorbed by the thin mucous membrane of the nasal cavity.
BilZ0r said:
I'm sure you will have no problem finding an authoratative citation or two to support you.
AznRaver said:source: DR. AznRaver
You're lucky i even read your post and responded. i don't have time to play with you anymore.
AznRaver said:complete crap. it's the negative charge not the esterification per say or the partition coefficients that resulted in one of the esterified carboxyl moiety of L-tyrosine having faster absorption rates than regular L-tyrosine. You also have to take into account that it had to convert to the parent compound, L-tyrosine for it to be absorbed intranasally. Is this conversion going to happen for all drugs? i don't think so.