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Interaction between amphetamine, celexa and bupropion

M

Mycelium

Greenlighter
Joined
Mar 2, 2007
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3
My doctor says otherwise but there has to be some interaction between SSRIs, Wellbutrin and amphetamine. I feel no buzz at all from the amphetamine, although the concentration effects are there somewhat. It's weird though. I can take 20-40mg of adderall and then go to sleep just fine an hour later. But if I choose to focus on work, I can.

I'm guessing it's the wellbutrin since it stops the release of dopamine (but also inhibits its reuptake, sort of keeps it leveled), but I'm not sure. Another thing that's weird is that Ritalin is far more pronounced than adderall. Not a "buzz" so much but it feels speedier.


400mg bupropion SR (200mg 2/day)
20mg celexa (lowest dose, 1/day)
modafinil on and off (100-200mg)
Adderall I take ~20-30mg on and off
Ritalin usually 20-40 but rare (causes headaches and jitters)

I usually potentiate the adderall with calcium carbonate. Seems to work, but still no buzz. Also, there's no real crash from the adderall. I can take 300mg of caffeine or 40mg of ritalin and feel like total shit after a few hours, but not so with adderall.

I don't care about a buzz. I'm just wondering why the effects are so weak? My friend took 20mg of adderall (first time) and he was blown away.
 
Celexa blocks the reuptake of serotonin. Bupropion blocks the reuptake of dopamine. Adderall releases both of these, but when u take drugs like wellbutrin and celexa your not going to feel the "euphoric push" from the adderall. Its essentially blocking that mechanism. The same would be true if you tried to take MDMA while on celexa or prozac. You really wont feel it that much. Either you need to take the SSRI's and bupropion alone or take the adderall alone. Dont get this confused either. Dont stop taking the celexa and bupropion just to catch a buzz. You might experience some nasty withdrawal from that. If you really want to take just the adderall then talk to ur doc about tapering off of the celexa and bup. Although coming of those just to catch a buzz from adderall seems like not a good idea but ultimatly its your choice.
 
well, it's not so much the general concept/theory. I need specifics on what's going on.

If celexa blocks the reuptake of serotonin (which it does), and adderall releases serotonin, it's a good thing - in the context that more serotonin is good. It would sort of be like a ghetto MDMA combination. This doesn't seem to be the case however. probably because adderall doesn't act so much on serotonin.

It's not the celexa that's interfering with the adderall in this case. I'm on the lowest possible dose and I've tapered off many times (in between trying different SSRIs). Wellbutrin is the only drug I've been taking long term on a steady basis (highly recommended - it's like a low dose of amphetamine 24/7).

What drug has more affinity for the dopamine receptors? I don't plan on tapering off anything I'm taking, but just curious.

I'm also wondering if the provigil's efficiency is being affected by what I'm taking. From the reports I've read, it shouldn't be, but I wouldn't be able to tell because I never took it alone.
 
bupropion is blocking the addy as well. Its a dopamine reuptake inhibitor. Celexa and bup both are blocking the reuptake sites so the addy can get in effectivley. Your not going to get the amphetamine feel if your taking bupropion. Amphetamines release serotonin, dopamine, and epinephrine. SSRIS and DRI's are going to interfere plain and simple. Not to mention tolerance.
 
Even if Bupropion is blocking DAT, it should not reduce the euphoriant effects. DARI + Amphetamine combos are commonly used, such as combining cocaine with meth
 
SSRI like Celexa counteract amphetamine:
Eur J Pharmacol. 1985 Dec 3;118(3):245-52.

Behavioral aspects of serotonin-dopamine interaction in the monkey.

Korsgaard S, Gerlach J, Christensson E.

The effects of serotonin (5-hydroxytryptamine; 5-HT) antagonists and 5-HT uptake inhibitors on the behavioral response to amphetamine and haloperidol in monkeys (cercopithecus aethiops) were investigated. Amphetamine increased locomotor activity and reactivity and induced repetitive movements of head, limbs and trunk, but no oral hyperkinesia. Haloperidol induced dystonia and parkinsonism. Pretreatment with the 5-HT antagonists cyproheptadine and mianserin increased amphetamine-induced locomotor activity, reactivity and repetitive movements and decreased haloperidol-induced dystonia and parkinsonism. Conversely the 5-HT uptake inhibitors paroxetine and CGP 6085 A decreased amphetamine-induced repetitive movements and aggravated haloperidol-induced dystonia and parkinsonism. The 5-HT uptake inhibitors produced oral hyperkinesia resembling human tardive dyskinesia, which was intensified by amphetamine and blocked by haloperidol. These findings support the suggestion that 5-HT inhibits dopamine functions and may imply that 5-HT antagonists could have a beneficial effect against acute extrapyramidal side-effects of neuroleptic treatment. 5-HT uptake inhibitors in the monkey may serve as a model for tardive dyskinesia.

PMID: 4085556 [PubMed - indexed for MEDLINE]
Click to expand...
 
Hammilton said:
Even if Bupropion is blocking DAT, it should not reduce the euphoriant effects. DARI + Amphetamine combos are commonly used, such as combining cocaine with meth
Click to expand...

yes true, but if your dopamine levels are higher in their baseline from wellbutrin the PERCENTAGE of increase from the amphetamine will not be as big as without wellbutrin so you may feel the effects less although they are as strong as ever...:D
 
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