Inherited/Natural tolerance to Opiates?

[face_rapist]

My first experience with opiates was when I got my wisdom teeth out. I was given 7.5 mg LT's and took way more than I was supposed to (misread the label) but experienced relatively nothing, and decided to save 3 of them to use after the surgery was healed to see if the pain simply masked the euphoria.

I took the 3 (22.5 mg hydrocodone) much later and still felt nothing.

Since then, I've eaten every opiate pill i could get my hands on to see if this was just a placebo, but i still experienced no euphoria, nothing but a slight calming effect identical to the description of a very low dose effect.

To date the the most i've done is snorted 40 mg of oxycodone and got nothing but the itchies; i actually went outside and mowed the grass!

yes, i'm absolutely positive it was real,

yes, i'm sure it was 40 mg (my friend broke an 80 in half and snorted about 10 mg of it and got fuct, i got the other half),

and yes, i'm sure it wasnt residual tolerance from a previous experience, I spaced out my experiments pretty far (at least a week, and in the 40mg case, it had been at least a month).

Can anyone explain this?

 

[theWorldWithin]

Yes some individuals have unusually low or high thresh holds for effects of different classes of drugs. But please be aware that just because you are feeling no euphoria does not mean that you are not experiencing any respitory depresion. In lay mans terms, do not take hero doses because of your natural resistance to opiods.

By the way this is not ADD, it belongs in other drugs.

 

[Splatt]

Yeah I agree. Don't think you just need more and more and won't OD.
I never relly got much from opiates unless it was combined with weed.

Once I did something stupid and kept snorting oxycontin. I believe it was around 160mg within one and a half to two hours, 40mg at a time. With no tolerance at all besides natural tolerance. And I finally got somewhere after all that, but I was getting horrible breathing problems. Then I nodded out, and woke up an hour later to my friend hitting me on the arm really hard and telling me to wake up. I felt my heart jump back to proepr beats and I jumped off of my seat fast, only to find out I was the only one in the house.

 

[burn out]

some people dont get euphoria off opioids when they first start using them. if you get yourself addicted youll probably start to like them then and youll be able to feel euphoria off even lower doses but its not worth it.

 

[mepat1111]

When I first started taking opiates I was the same. With little to no tolerance I ate 60mg of oxycodone and only got respitory depression, similar to the above poster, I only found it really hard to breath and almost blacked out. I worked at it, and worked at it, until I forced myself to start liking it, then got myself addicted to it.

Yeah I'm smart aren't I?

I'm on 8mg of Buprenorphine a day now, and suffer from all sorts of nasty drug-related mental illnesses (refere to TDS for more info), I also tried to kill myself 6 or 8 weeks ago. Don't make the same mistakes I did, think of yourself as blessed that you don't enjoy the stuff.

 

[haribo1]

Hydrocodone & oxycodone are both prodrugs. Have you tried morphine, hydromorphone or similar. In Japan, codeine is totally ineffective for 15% of the population because their bodies cannot do the 3-demethylation. Try methadone, thats cheap, long-lasting and if your not into opiates gives a good high...

 

[almost-]

I had no tolerance to opiates, and I tried suicide: ~10mg fentanyl IM

I puked a lot, wet my pants etc, the high lasted about 12h, then I was OK.

The high was similiar to that:

Does anyone here shoot heroin in such high doses that is goes beyond being fun? I'm talking about making such a large shot - intentionally - that you know it will override the euphoria, that you will be puking every 5 steps, that you won't see straight, and that you'll feel like shit. And at the same time, you will be so fucked out of your mind you won't care?

Anyone ever push it to this level? I'm starting to...

And it's not logical.

http://www.bluelight.ru/vb/showthread.php?t=282271

 

[face_rapist]

just to alleviate any worries, i'm not taking "hero doses" of opiates in an attempt to break my tolerace or anything, i just wanted to see if my tolerance is normal.

is there anything i can do so that i can enjoy opiates?

i've only tried hydrocodone and oxycodone, just to clarify, if i didnt make that clear in the first post.

 

[haribo1]

Well, that could be the problem. Try some morphine and see if that works.

 

[Helios.]

See also Shulgin's term, HARD HEADEDNESS.

 

[Psychubus]

Yeah I agree. Don't think you just need more and more and won't OD.
I never relly got much from opiates unless it was combined with weed.

Once I did something stupid and kept snorting oxycontin. I believe it was around 160mg within one and a half to two hours, 40mg at a time. With no tolerance at all besides natural tolerance. And I finally got somewhere after all that, but I was getting horrible breathing problems. Then I nodded out, and woke up an hour later to my friend hitting me on the arm really hard and telling me to wake up. I felt my heart jump back to proepr beats and I jumped off of my seat fast, only to find out I was the only one in the house.

big deal, ive had 40mg shots with no tolerance; this doesnt necessarily mean that other people can do the same, or that i can do this with any drug, but in this specific case i was able to tolerate oxycontin fairly well. my breathing was fine, and im like 1/5 of your size. you were probably unable to breathe because your weight problems are finally catching up to you.

also, were your OC's blue/green-ish colored or white? were they the originals or the newer ones? generic?

 

[IGNVS]

looks like nobodys answerd your question, and i dont know much about opiates, so im gonna say probably reaserch a little into that 15% japaneese thing, the genetics behind that...it probably has something to do with an enzyme. then i would sugest trying to find out a bit more about the chemestry of hydros and oxies and look at what enzymes do what to turn it into this or that that then goes to your brain. learn about all that then look up stuff about the receptors and such and similar cases to yours. google is your freind. i would do all that reaserch for you and poop out an answer but i dont want to. but its probably completly regular to have no big euphoric reaction to the stuff.

 

[hussness]

I have also heard that around 10% of the white population is deficient in CYP2D6, the enzyme that performs the O-demethylation on opiates. I was interested in whether a lacking of this enzyme would prevent me from experiencing effects of hydrocodone and oxycodone, but I don't think this is the case. I don't have the source on me, but I'm pretty sure oxycodone and hydrocodone have affinities for the mu receptor that are around 15-17 nm. So lacking CYP2D6 shouldn't prevent you from experiencing a "high" off these drugs, even if it could for all intents and purposes block the analgesic effects of codeine. I would really like this question answered since I'm display almost no response to codeine, and only a slight response to high doses of oxycodone (40 mg range). I do remember when I was six and had surgery they gave me IM morphine, and that was wonderful, so I do want to find the answer to this problem.

 

[Splatt]

big deal, ive had 40mg shots with no tolerance; this doesnt necessarily mean that other people can do the same, or that i can do this with any drug, but in this specific case i was able to tolerate oxycontin fairly well. my breathing was fine, and im like 1/5 of your size. you were probably unable to breathe because your weight problems are finally catching up to you.

also, were your OC's blue/green-ish colored or white? were they the originals or the newer ones? generic?

you don't contribute anything useful to these forums, go away.

 

[theWorldWithin]

I have also heard that around 10% of the white population is deficient in CYP2D6, the enzyme that performs the O-demethylation on opiates. I was interested in whether a lacking of this enzyme would prevent me from experiencing effects of hydrocodone and oxycodone, but I don't think this is the case. I don't have the source on me, but I'm pretty sure oxycodone and hydrocodone have affinities for the mu receptor that are around 15-17 nm. So lacking CYP2D6 shouldn't prevent you from experiencing a "high" off these drugs, even if it could for all intents and purposes block the analgesic effects of codeine. I would really like this question answered since I'm display almost no response to codeine, and only a slight response to high doses of oxycodone (40 mg range). I do remember when I was six and had surgery they gave me IM morphine, and that was wonderful, so I do want to find the answer to this problem.

Absolutely correct. Although oxycodone does metabolize into oxymorphone the amount is so small that it is beyond the range of most CGMS equipment. It has almost no effect on the analgesia and certianly nothing from a recreational standpoint. I don't understand why so many people continually post about oxycodone to oxymorphone.

 

[Enlitx]

Absolutely correct. Although oxycodone does metabolize into oxymorphone the amount is so small that it is beyond the range of most CGMS equipment. It has almost no effect on the analgesia and certianly nothing from a recreational standpoint. I don't understand why so many people continually post about oxycodone to oxymorphone.

Because people get off at the idea of having the holy grail of opioids in their system?

 

[Cloud_9]

I have also heard that around 10% of the white population is deficient in CYP2D6, the enzyme that performs the O-demethylation on opiates. I was interested in whether a lacking of this enzyme would prevent me from experiencing effects of hydrocodone and oxycodone, but I don't think this is the case. I don't have the source on me, but I'm pretty sure oxycodone and hydrocodone have affinities for the mu receptor that are around 15-17 nm. So lacking CYP2D6 shouldn't prevent you from experiencing a "high" off these drugs, even if it could for all intents and purposes block the analgesic effects of codeine. I would really like this question answered since I'm display almost no response to codeine, and only a slight response to high doses of oxycodone (40 mg range). I do remember when I was six and had surgery they gave me IM morphine, and that was wonderful, so I do want to find the answer to this problem.

I happen to have an over active cyp450 pathway in my liver [genetics tests proved it, I'm not speculating] and I have the same kind of problem some of you guys are talking about. I can take "heroic" doses of opiates and have no recreational effect at all. In fact, right now I am taking 240mg of oxycontin every day for my chronic nerve pain condition and recieve absolutely no euphoria from it and very little pain relief; but then again it works better than anything else.

For one I'm glad I hardly get any eiphoria out of my opiates as I tend to get pain relief without some of the loopiness and groggyness that some of people in the chronic pain clinic I interact with say they get at exponentilly smaller doses. Even during surgery they gave me the max dose of morphine they could IV and I got up and walked out of the hospital in frustration [for other reasons] and the nurses and doctor were amazed at my ability to handle opiates [without a tolerance at that point.]

Basically I'm sayin is that it happens [to about 6% of the white population] and you have to either tak a lot more or just give up. Sometimes though when you take more you will get the respiratory depression and itchiness without the pain relief and euphoria and can easily overdose not knowing your own tolerance because you can't feel it comming on in the sense a normal person would be able to.