Thanks so much for sharing your experience and situation jona, and I'm sorry to hear that you've got therapy-immune depression. I had treatment-resistent depression for many years as well, but eventually for some reason (or much more likely, a very complex and intricate combination of reasons lol) my depression started responding to Cymbalta and low-dose Topamax, 8 years ago, which I am still currently on and I DARE NOT stop taking for fear that my depression will return.