Hey guys I’ve had an issue over the last 3 years with feeling euphoria from opiates but there’s a lot of factors so might be a long ready but any help is much appreciated 
so about 4 years ago I discovered opiates due to a neck injury and it began with tramadol needing only 50-100mg for full blown euphoria. Over the course of 6-7 months use was minimal and was probably about a packet (20x50mg) per month if not less and I handled keeping use to a minimal well I could have a packet sit around for weeks and only dabble when a perfect setting came up.During this time I also discovered oxycodone (endone 5mg) needing 10-15 max for incredible euphoria 15mg sometimes even putting me to sleep. In the period only used oxy a few times and went through 2 packets in the 6-7 month period and once came across a 20mg oxynorm which was the most intense feeling I’d ever felt. Now to the point December that same year went on a trip where I was introduced to MDMA witj no knowledge on the drug I recklessly used it every second day for 2 weeks and in doses I’d say were damaging due to lack of knowledge and is a massive regret. The same week I left for the trip I was prescribed risperidone an antipsychotic which I started days before the trip,after returning home I didn’t bother with opiates as I learned that antipsychotics made them ineffective. After 5-6 months I quit the antipsychotics due to mood/emotional side effects and was placed on antidepressants and hoped to enjoy opiates Again only to find they didn’t work (I only tried oxy after the period due to it being my favourite)... then learning most anti depressants block opiates due to the cyp2d6 liver enzyme. Despite every turn I tried constantly by weaning off meds for few days to see if it changed effects then returning to normal dose once realising no change was made. I was then taken off anti depressants and placed on lithium due to a new diagnosis of bipolar disorder. While looking forward to the mood stabalizing effects it also came to me “maybe I’ll be able to enjoy opiates again also” after minimal research found no info on lithium blocking opiates so give it A crack. Of course Notning again, out of frustration I tried multiple times, at most 2-3 nights in a week I’d try a single dose for a month before giving up, I made a blue light post at the time questioning lithium’s effect and got some good info in return that it might possibly be a culprite! Due to my doc giving oxycodone for a brief time they decided to change back to tramadol for management due to oxy being much more addictive and potent. To my surprise tramadol give me a decent high despite me being on lithium also, but most likely due to the snri properties not the opiate ones, as It was obvious to me no way would the opiate part of tramadol have a higher effect on me compared to the oxy they don’t even compare there. From that day for a 2 year period I was given tramadol weekly which I used in most cases anywhere from 1-4 days per week eventually taking slow release forms and sometimes upto 400-600mg per day but never daily use for longer then 4 days maximum and never experienced withdrawal in any form. During this 2 year period of oxy came my way I’d give a it a shot despite knowing I’d almost 100% be disappointed about 8 times per year it’d come my way and I’d try and felt Notning at all, toward the end I wondered about someone of a tolerance or cross tolerance from tramadol sour experimented doses from 20mg-60mg orally to feel notning but histamine release and in the 60mg doses minimal mood effects and by minimal I mean minimal like almost A natural mood lift in a slightly good day wouldn’t have even considered it euphoria. 80-100mg insufflayed was also tried for the same outcome as 60mg orally. I have sort Taken tolerance off my list of reasons since when I started the 2 year tramadol use I had at most only taken oxy 3 times in a week and never more then 30mg so my experimentation witj 60mg orally should never had required to be tjay high since my tolerance shouldn’t be close to that due to never Ever taking a single dose close to that let alone frequently. During the period also tried potentiatinf with grapefruit juice, promethazine, Dxm, orphenadrine witj no difference. On one rare occasion a year after starting tramadol frequently I took 25mg of oxy to feel Mild euphoria, very mild but was definitely euphoria, to try again the following day at 30mg to experience notning. My Main
Confusion is prior to that trip away 2-3 5mg tablets could put me in pure heaven, everytime without a miss, now 60mg not even a single mood lift even though oxy was only used once every 2 month ish in the period leading up. I have now come off lithium for 3 weeks due to being stable for a fair time but I’m afraid to bother wasting more time and opiates and I am wondering if anyone has any knowledge or tips that could give me a clue of what the issue is here I know it’s complex and long to read but I will
Greatly appreciate anyone’s time and help !
so in shorter term I enjoyed opiates easily and minimal dosage up until that December which then followed with
-Heavy MDMA usage for 2 weeks every second day atleast and one particular night a dosage of 1000mg (ridiculous I know but poor knowledge and wasn’tthinking due to already being intoxicated. (Possible brain chemistry damage affecting dopamine? I am aware MDMA is more serstonin though)
-roughly 5 months antipsychotic use (dopamine againist can cause permanent change on dopamine in brain, possibly blocking excessive dopamine opiates produce ?)
-anti depressants which affect opiates due to cyp2d6 enzyme (shouldn’t have any problematic effect at this current time, only at the time of use)
-Lithium carbonate usage for 1-2 years (I’m not sure how but in a previous post I received info on lithium blocking effects of opiates and hear of other users reporting similar problem)
- Tolerance? This I doubt as oxy use was at most 2-3 times a week and at times didn’t use for 3 months at a time, While trying to work out why they wouldn’t work for me, while they did work wasn’t more then once a month maybe even less. Also tramadol for 2 years upto 4 days weekly cross tolerance ? This I also doubt as prior to and in early stages of tramadol use oxy still
Had no effect. (Side note also tried codiene,dihydrocodiene,morphine all with no effect beside side effects)
thankyou everyone for your time and I really apologise for the length of this post!
so about 4 years ago I discovered opiates due to a neck injury and it began with tramadol needing only 50-100mg for full blown euphoria. Over the course of 6-7 months use was minimal and was probably about a packet (20x50mg) per month if not less and I handled keeping use to a minimal well I could have a packet sit around for weeks and only dabble when a perfect setting came up.During this time I also discovered oxycodone (endone 5mg) needing 10-15 max for incredible euphoria 15mg sometimes even putting me to sleep. In the period only used oxy a few times and went through 2 packets in the 6-7 month period and once came across a 20mg oxynorm which was the most intense feeling I’d ever felt. Now to the point December that same year went on a trip where I was introduced to MDMA witj no knowledge on the drug I recklessly used it every second day for 2 weeks and in doses I’d say were damaging due to lack of knowledge and is a massive regret. The same week I left for the trip I was prescribed risperidone an antipsychotic which I started days before the trip,after returning home I didn’t bother with opiates as I learned that antipsychotics made them ineffective. After 5-6 months I quit the antipsychotics due to mood/emotional side effects and was placed on antidepressants and hoped to enjoy opiates Again only to find they didn’t work (I only tried oxy after the period due to it being my favourite)... then learning most anti depressants block opiates due to the cyp2d6 liver enzyme. Despite every turn I tried constantly by weaning off meds for few days to see if it changed effects then returning to normal dose once realising no change was made. I was then taken off anti depressants and placed on lithium due to a new diagnosis of bipolar disorder. While looking forward to the mood stabalizing effects it also came to me “maybe I’ll be able to enjoy opiates again also” after minimal research found no info on lithium blocking opiates so give it A crack. Of course Notning again, out of frustration I tried multiple times, at most 2-3 nights in a week I’d try a single dose for a month before giving up, I made a blue light post at the time questioning lithium’s effect and got some good info in return that it might possibly be a culprite! Due to my doc giving oxycodone for a brief time they decided to change back to tramadol for management due to oxy being much more addictive and potent. To my surprise tramadol give me a decent high despite me being on lithium also, but most likely due to the snri properties not the opiate ones, as It was obvious to me no way would the opiate part of tramadol have a higher effect on me compared to the oxy they don’t even compare there. From that day for a 2 year period I was given tramadol weekly which I used in most cases anywhere from 1-4 days per week eventually taking slow release forms and sometimes upto 400-600mg per day but never daily use for longer then 4 days maximum and never experienced withdrawal in any form. During this 2 year period of oxy came my way I’d give a it a shot despite knowing I’d almost 100% be disappointed about 8 times per year it’d come my way and I’d try and felt Notning at all, toward the end I wondered about someone of a tolerance or cross tolerance from tramadol sour experimented doses from 20mg-60mg orally to feel notning but histamine release and in the 60mg doses minimal mood effects and by minimal I mean minimal like almost A natural mood lift in a slightly good day wouldn’t have even considered it euphoria. 80-100mg insufflayed was also tried for the same outcome as 60mg orally. I have sort Taken tolerance off my list of reasons since when I started the 2 year tramadol use I had at most only taken oxy 3 times in a week and never more then 30mg so my experimentation witj 60mg orally should never had required to be tjay high since my tolerance shouldn’t be close to that due to never Ever taking a single dose close to that let alone frequently. During the period also tried potentiatinf with grapefruit juice, promethazine, Dxm, orphenadrine witj no difference. On one rare occasion a year after starting tramadol frequently I took 25mg of oxy to feel Mild euphoria, very mild but was definitely euphoria, to try again the following day at 30mg to experience notning. My Main
Confusion is prior to that trip away 2-3 5mg tablets could put me in pure heaven, everytime without a miss, now 60mg not even a single mood lift even though oxy was only used once every 2 month ish in the period leading up. I have now come off lithium for 3 weeks due to being stable for a fair time but I’m afraid to bother wasting more time and opiates and I am wondering if anyone has any knowledge or tips that could give me a clue of what the issue is here I know it’s complex and long to read but I will
Greatly appreciate anyone’s time and help !
so in shorter term I enjoyed opiates easily and minimal dosage up until that December which then followed with
-Heavy MDMA usage for 2 weeks every second day atleast and one particular night a dosage of 1000mg (ridiculous I know but poor knowledge and wasn’tthinking due to already being intoxicated. (Possible brain chemistry damage affecting dopamine? I am aware MDMA is more serstonin though)
-roughly 5 months antipsychotic use (dopamine againist can cause permanent change on dopamine in brain, possibly blocking excessive dopamine opiates produce ?)
-anti depressants which affect opiates due to cyp2d6 enzyme (shouldn’t have any problematic effect at this current time, only at the time of use)
-Lithium carbonate usage for 1-2 years (I’m not sure how but in a previous post I received info on lithium blocking effects of opiates and hear of other users reporting similar problem)
- Tolerance? This I doubt as oxy use was at most 2-3 times a week and at times didn’t use for 3 months at a time, While trying to work out why they wouldn’t work for me, while they did work wasn’t more then once a month maybe even less. Also tramadol for 2 years upto 4 days weekly cross tolerance ? This I also doubt as prior to and in early stages of tramadol use oxy still
Had no effect. (Side note also tried codiene,dihydrocodiene,morphine all with no effect beside side effects)
thankyou everyone for your time and I really apologise for the length of this post!
