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Improved solubility of Salvinorin A

SWIMMY

Greenlighter
Joined
May 18, 2010
Messages
38
I found this dissertation:

THE SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SALVINORIN A
ANALOGUES AS OPIOID RECEPTOR PROBES

By Kimberly M. Lovell

They investigate if cyclodextrins can aid in the solubility of Salvinorin A in water.

They use a cyclodextrin called Captisol

Captisol® is a modified beta-cyclodextrin (beta-CD) known also as (SBE)7m-beta-CD. SBE refers

to sulfobutyl ether substitutions variably substituted at the 2-, 3-, and 6- position of beta-CD while 7

refers to the average degree of subsitution.323

And the solubility does improve:

The solubility of

salvinorin significantly increased with increasing concentrations of Captisol®. The effects of

different concentrations of Captisol® on the solubility of salvinorin A are summarized in Table 6

as fold increased relative to salvinorin A in sterile water. The solubility of salvinorin A was




highest with the greatest concentration of Captisol®. Use of 2.5 M Captisol® was found to

increase the aqueous solubility of salvinorin A approximately 50-fold.


Increasing concentrations of Captisol® in sterile water increased the solubility of

salvinorin A, which identifies a new vehicle for salvinorin A delivery. One of the most used

formulations to assist with salvinorin A solubility in in vivo studies is the mixture of Tween-

80:ethanol:saline (1:1:8 ). This vehicle cocktail still uses ethanol, which is unsatisfactory given

its known opioid effects.305 Even with the use of ethanol, only 0.2 mg/mL of salvinorin A is able

to be solubilized in solution.308 By using Captisol® we were able to successfully solubilized 0.5

mg/mL of salvinorin A in sterile water with the potential to limit the negative effects of currently

known vehicles. Thus, we have identified Captisol® as a solubilizing agent to assist in the

pharmacological evaluation of salvinorin A and salvinorin A derivatives.

I find this interesting, I liked the sublingual approach of Salvia, I did it with alcohol... but it does burn !

I'm in the process of ordering HPBCD... I will try it out

Anyone else tried this ?
 
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This'll likely be merged in with the Big & Dandy Salvia thread soon, just letting you know beforehand, as being new you get the chance to reply to the thread first :)

Sounds interesting, worth a shot :)
 
Interesting.. and speaking of shot, I wonder how salvinorin A would feel injected IV.
 
I don't understand why you would inject a drug you could simply eat or smoke... I understand the nature of people, especially ones who like to experiment why psychs, wanting to push the boundaries... but you have to stop somewhere. Just seems stupid and unnecessary IMO.

Regarding the actual topic though, does Captisol have any effects in humans when consumed?
 
^IVing salvinorin A is not reported to be that different than smoking, just like IVing DMT is not that much different than smoking (though IVing is reportedly a lot less painful if you find the smoke harsh).

IMing salvinorin A, on the other hand, seems extraordinarily justified to me as a potential means of experiencing yet unrevealed attributes of consciousness. And maybe now I have a means (thanks for the info, OP!). I've tried IMing it before, with DMSO. I didn't feel anything. I was using just a milligram of salvinorin A, so it was hard to even see if it dissolved (though it should have) The reason I think it's potentially so valuable is because using IM would presumably be slower in its onset than smoking (which often results in a confusing experience), but much faster than sublingual (which often results in non-breakthrough experiences).

IMing may be a way to reach the "breakthrough" visionary salvia state in a way where it is possible to "watch the doors of perception open" to the beyond, rather than shatter them as we careen through as during smoking. Typically, with smoking, the onset is so rapid that you simply find yourself in the thrall of the state, barely aware of how you reached that point.

The most valuable aspect of the salvia experience, to my mind, is observing how sober consensus reality reassembles on the return. Why does the recognition of your identity, knowledge that you took a drug, and the time and place in which you are, return to consciousness in the way and in the order that it does for you? How does it return to you, and how might finding that answer refine your perspective on the nature of perception? The return is a way to peak under the hood, to observe and analyze the nature of your self reforming in real time from a perspective unique to the world of mind altering substances.

However, there is no way (at least for me, as sublingual doesn't work well for me) to watch the reality of the self disassemble during entry into the visionary state (because it happens so quickly when smoking). Perhaps, if we could slow down the onset and really feel our world crumbling -- feel where in the foundation of consciousness the fissure is formed and how and where the first blocks fall, enter the visionary state, and slowly return -- then integrate the narrative of the "descent" and "ascent" into and out of salvia space it would reveal something invaluable about the structure of our individual consciousnesses.

It's difficult for me to imagine a more compelling reason to IM inject any other drug. I'm aware of no such reports with salvia, either.

My plan has always been to IM it while on DXM or ketamine, as combining with dissociatives maximizes the lucidity of the salvia experience without really altering the more interesting content.
 
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Regarding the actual topic though, does Captisol have any effects in humans when consumed?

It would be best if such a carrier didn't have pharmacological properties itself, but I don't know if this is the case. I also didn't find any way to buy Captisol.
 
^IVing salvinorin A is not reported to be that different than smoking, just like IVing DMT is not that much different than smoking (though IVing is reportedly a lot less painful if you find the smoke harsh).

IMing salvinorin A, on the other hand, seems extraordinarily justified to me as a potential means of experiencing yet unrevealed attributes of consciousness.

or perhaps subcutaneous ? perhaps it would also spread the effects, but I don't know, there seem to have been a study with subcutaneous injections in non-human primates

The discriminative effects of the κ-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects

Figure 3 in this study reveals that the facial relexation (because of the salvinorin A) takes more time to reach a maximum with a subcutaneous injection as it does with an iv injection
 
I tried the salvia in a solution of alcohol - "an extraordinary potion of enchantment" it said on the label, cost a fortune. Gave a pleasant enough experience but not really worth the effort of taking the skin off your tongue holding the salvia/alcohol in your mouth.
 
yes, i first tried it with alcohol too. It worked the first 2 times. The second time I had difficulty remembering that I was human, I was only a consciousness and a consciousness is not human

so that was very interesting, the effects are quite different too !

but then I tried it a third time and the effects were gone, I don't know why
 
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