I found this dissertation:
THE SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SALVINORIN A
ANALOGUES AS OPIOID RECEPTOR PROBES
By Kimberly M. Lovell
They investigate if cyclodextrins can aid in the solubility of Salvinorin A in water.
They use a cyclodextrin called Captisol
And the solubility does improve:
I find this interesting, I liked the sublingual approach of Salvia, I did it with alcohol... but it does burn !
I'm in the process of ordering HPBCD... I will try it out
Anyone else tried this ?
THE SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SALVINORIN A
ANALOGUES AS OPIOID RECEPTOR PROBES
By Kimberly M. Lovell
They investigate if cyclodextrins can aid in the solubility of Salvinorin A in water.
They use a cyclodextrin called Captisol
Captisol® is a modified beta-cyclodextrin (beta-CD) known also as (SBE)7m-beta-CD. SBE refers
to sulfobutyl ether substitutions variably substituted at the 2-, 3-, and 6- position of beta-CD while 7
refers to the average degree of subsitution.323
And the solubility does improve:
The solubility of
salvinorin significantly increased with increasing concentrations of Captisol®. The effects of
different concentrations of Captisol® on the solubility of salvinorin A are summarized in Table 6
as fold increased relative to salvinorin A in sterile water. The solubility of salvinorin A was
highest with the greatest concentration of Captisol®. Use of 2.5 M Captisol® was found to
increase the aqueous solubility of salvinorin A approximately 50-fold.
Increasing concentrations of Captisol® in sterile water increased the solubility of
salvinorin A, which identifies a new vehicle for salvinorin A delivery. One of the most used
formulations to assist with salvinorin A solubility in in vivo studies is the mixture of Tween-
80:ethanol:saline (1:1:8 ). This vehicle cocktail still uses ethanol, which is unsatisfactory given
its known opioid effects.305 Even with the use of ethanol, only 0.2 mg/mL of salvinorin A is able
to be solubilized in solution.308 By using Captisol® we were able to successfully solubilized 0.5
mg/mL of salvinorin A in sterile water with the potential to limit the negative effects of currently
known vehicles. Thus, we have identified Captisol® as a solubilizing agent to assist in the
pharmacological evaluation of salvinorin A and salvinorin A derivatives.
I find this interesting, I liked the sublingual approach of Salvia, I did it with alcohol... but it does burn !
I'm in the process of ordering HPBCD... I will try it out
Anyone else tried this ?
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