justtesting
Bluelighter
- Joined
- Sep 24, 2010
- Messages
- 52
I could not reply privately to PHD in PRT, so here is a copy of my reply:
According to the author of the 13 step procedure (he doesn't want his handle known, so I'll call him 7of9 if I need to refer to him again in this message), it worked to dissolve PEO in isopropanol, which did not dissolve the API. He chose this based on what he read in cleaning materials for polyox work areas
Purdue intended it to be difficult to separate the API from the PEO, and seems to have done what they intended.
I do not know if that is only because they are able to encase individual micro-particles of the API in cured polyox (brand name of PEO) resin, or if the polyox chains are so large that they are able to wrap around the API micro-particles.
I do know that the molecular weight of the PolyOX that they have chosen is in the millions, so that may be possible. PolyOx literature talks about the capability of forming "association compounds" with various drugs. Do you know if such wrapping is what they mean by "association compound"? I couldn't find anything useful via web search.
Gelling seems to be what results in drug release, so maybe that lets the resin become flexible enough to allow molecules of oxycodone to escape, after which diffusion through the gel is like wading in mollasses.
The general idea of the method I proposed after reading 7of9's method is this:
Forgive my ignorance (or missing brain cells), but what is a PHD in PRT? (i.e. what does PRT stand for in this context?)
-- justtesting
PHD_in_PRT said:After reading his reply I did some research and anything I could find that Polyethylene Oxide is soluble in that is not only toxic but they it would also dissolve the main ingredient also soluble in the solvent.
According to the author of the 13 step procedure (he doesn't want his handle known, so I'll call him 7of9 if I need to refer to him again in this message), it worked to dissolve PEO in isopropanol, which did not dissolve the API. He chose this based on what he read in cleaning materials for polyox work areas
Purdue intended it to be difficult to separate the API from the PEO, and seems to have done what they intended.
I do not know if that is only because they are able to encase individual micro-particles of the API in cured polyox (brand name of PEO) resin, or if the polyox chains are so large that they are able to wrap around the API micro-particles.
I do know that the molecular weight of the PolyOX that they have chosen is in the millions, so that may be possible. PolyOx literature talks about the capability of forming "association compounds" with various drugs. Do you know if such wrapping is what they mean by "association compound"? I couldn't find anything useful via web search.
Gelling seems to be what results in drug release, so maybe that lets the resin become flexible enough to allow molecules of oxycodone to escape, after which diffusion through the gel is like wading in mollasses.
The general idea of the method I proposed after reading 7of9's method is this:
- (optional) Use fatty solvent, such as orange oil to remove the fat-soluble anti-oxidant BHT. May not be necessary when using more than just oxidation (for example, UV light) to degrade the PolyOx.
- degrade the PolyOx to reduce its ability to bind the API. Use strong UV light and oxidation (via aeration of next step's solvent) to degrade PolyOx. This probably can only be done concurrently with the next step.
- dissolve degraded Polyox so as to discard it, agitating to liberate the API (and possibly for shear forces to speed up degradation)
- remove dissolved (and ungelled) PolyOx and solvent by wick filtration, leaving solids.
Don't discard the solvent containing PolyOx just yet. There still may be bound API, so you may want to repeat the previous steps to try to release it. Once released from the PolyOx, it should sediment out, apparently like magic. There will be diminishing returns with each repetition
Perhaps 7of9 or someone else could comment on any problems they might see with the above?
- Use traditional method, such as original OC method, and modified as needed, to separate water soluble solids from the others, to produce a water soluble powder. The only difference is that you will start with powder from preceding steps, rather than powder from grinding pills.
Forgive my ignorance (or missing brain cells), but what is a PHD in PRT? (i.e. what does PRT stand for in this context?)
-- justtesting