Sorry for bringing up this old thread, but loperamide has recently been of interest to me as I've heard people speaking about getting high from large doses on IRC.
I was looking at this link posted from page 1:
http://dmd.aspetjournals.org/content/32/9/943.full
I do not really understand most of it, but is this saying that unmodified loperamide, if allowed to cross the bbb, may on its own form toxic metabolites?
If this is the case...then one who is trying to take large doses coupled with quinidine etc to allow loperamide to cross the bbb is likely to be unwise?
I was looking at this link posted from page 1:
http://dmd.aspetjournals.org/content/32/9/943.full
I do not really understand most of it, but is this saying that unmodified loperamide, if allowed to cross the bbb, may on its own form toxic metabolites?
If this is the case...then one who is trying to take large doses coupled with quinidine etc to allow loperamide to cross the bbb is likely to be unwise?