I'm an ultrarapid CYP3A metabolizer

[faithingasoline]

Hi everyone, first post here. As the title says, I metabolize drugs extremely quickly. I got tested recently because the highest doses allowed of all the psychiatric drugs I have been prescribed aren't enough for me. I was told by my doctor that she's sure it's my metabolism and that when I get the results the thresholds can be dismissed and I will be given higher doses. The gene (CYP3A4) that metabolizes over 50% of drugs used in medicine and another one (CYP3A5) are both rapid. When it comes to recreational use, even though I'm a very small framed person, I have to take amounts experienced drug users take even when I'm trying something for the first time. The test results state my initial dosing should be 1.5-2 times higher than the standard, plus because of a certain combination I might need even higher doses. Does anyone have experience or knowledge on this?

 

[mdaniel80]

Hi everyone, first post here. As the title says, I metabolize drugs extremely quickly. I got tested recently because the highest doses allowed of all the psychiatric drugs I have been prescribed aren't enough for me. I was told by my doctor that she's sure it's my metabolism and that when I get the results the thresholds can be dismissed and I will be given higher doses. The gene (CYP3A4) that metabolizes over 50% of drugs used in medicine and another one (CYP3A5) are both rapid. When it comes to recreational use, even though I'm a very small framed person, I have to take amounts experienced drug users take even when I'm trying something for the first time. The test results state my initial dosing should be 1.5-2 times higher than the standard, plus because of a certain combination I might need even higher doses. Does anyone have experience or knowledge on this?

Grapefruit juice and other CYP inhibitors may be of great value to you bro

 

[Skorpio]

CYPs vary so much within the population. As a rapid metabolizer, you likely have an extra copy or two of cyp3a4 in your genome, so every time the dna goes to RNA and then protein you get 2 for the price of one. (Poor metabolizers usually have either a point mutation that lessened the function of the protein or a bigger mutation that totally junks the protein such as an early stop codon.

Using higher doses could be more simpler than inhibitors, as you don't have to worry about steady state inhibition, but tagamet or white grape fruits could be a useful tool in your arsenal for dire situations.

I think it would be worthwhile looking into the metabolism of drugs you take beforehand, as there are drugs primarily metabolized by other cyps (or even other enzymes), and you wouldn't want to dose too high and get a bad reaction.