How long does it take for Gabapentin to work? Let say hypothetically that one needs something ASAP in order to survive until next appointment. In a long term Benzo (Bromazepam) makes TRD worse. But how about just for 3-4 days? Any advice is much appreciated.
I've been taking amitriptyline for the last decade. Currently on 150mg at bedtime with zero antidepressant effect. Just gives me a few extra hours of sleep and that's it.
In conclusion. When mild opioids stop working for TRD (Treatment Resistant Depression) due to tolerance, we don't have much choice. A few benzos, antipsychotics and that's basically it. New treatments apparently work but due to extremely high price are not accessible by general population. If anybody here had a chance to try: esketamine, MDMA, psilocybin... PLEASE let us know is it working, how does it feel and is it worth the money? Thanks.
Thanks mate for being honest. I am sorry to hear that Ketamine didn't work for your depression. I guess one does not know is it helpful until tries it. Just one month of esketamine nasal spray therapy costs around $3000 with no guarantees. I could find (borrow) borrow that money but I see no point because you need at least several sessions in order to find out is it good for you. I am officially diagnosed with TRD but my GP still makes me try all kinds of SSRI'S with no results at all. It's hard to accept the fact that my TRD is incurable. I wish there's some hope at the horizon but that's all just a wishful thinking.
Are you in Australia? You sound like it by saying mate. I only ask as I am in Australia also and very interested in trying ketamine for depression.
I am mate. Born and raised in Adelaide. Saw my Psychiatrist recently and he told me that esketamine nasal spray Spravato won't be affordable any time soon. It's not covered by Medicare and weekly treatment costs around $800-900.
This is a very important topic which can (literally) save lives. We are not talking about painkillers for recreational use. We are talking about minimal dose for TRD. Most overdose cases happen by accident. But some of them are intentional, due to a lack of treatment for depression. I woke up this morning with a dark thoughts and was unable to get out of bed. Took 10mg Endone and after 15-20 minutes l am writing this post and feeling "normal". Some will call it a miracle but I think there's a logical explanation for all of this. Opiates improve your mood and that's a fact. It's not easy but it's doable. All one needs is a discipline. Unfortunately it's not easy to get Government's approval for this kind of treatment. All they care about are rules, not our health. It's been almost a year since I started this treatment and results are amazing. Next month my Dr. has to reapply again and I am really scared. What if they say NO? Why do l have to feel like a criminal just because I want to live? So PLEASE let's continue this topic as it gives HOPE to many of us. BLUELIGHT saved more lives than all outdated "therapies" combined. So any advice or experience will be helpful and greatly appreciated. Thanks.
I also have a chronic pain (headache) for the last 15-20 years and Endone is prescribed for that. For me it's the only Medication (off the label) that relieves symptoms of TRD. To be honest I will swap my depression for the most painful headache at any time. I asked my Psychiatrist about tolerance and in his opinion l shouldn't be worried at such a small dose. When I first tried Endone I felt a bit relaxed and that feeling is long gone. But it still works like a charm for TRD. In my humble opinion only people who would complain about tolerance are recreational users. I can't afford to be one of them because if I take more than 10mg today, I'll have nothing for tomorrow. It's not easy and it took me a while to learn how to resist a temptation. It would be nice to hear from people (if any) who tried some of the new treatments (MDMA, psilocybin, Spravato nasal spray).
I am done with Paracetamols and my GP is surprised that my liver is still OK. Psychiatrist is a 100% with me regarding 10mg Endone. He said there is no cure for TRD and not to expect any breakthrough in the next couple of years. Meanwhile small dose of opioids is the only thing that can ease the symptoms. Maybe something else would have better effect than Endone but I'm not sure if the government would approve it? Can't afford to gamble with my lifeline.
Tapentadol oral solution and tablet are used to treat pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. The extended-release tablet is used to treat severe pain, including pain caused by nerve damage from diabetes.
I agree. They work for most people and that's the fact. But there's a small percentage of us with TRD. There are 5 major groups of antidepressants and over the years l tried at least top 3 from each category.
In general you are absolutely right. But there's always exception that proves the rule.