N&PD Moderators: Skorpio | thegreenhand
^ Wouldn't that (the compound above) be hydrolyzed immediately like most acid anhydrides?
from US20050154002A1, carbonate ester prodrug of 3-Ac-dihydromorphine
This brings up an interesting legal question: is the dimer of a compound an analogue of it? That would be an interesting case to see!
simply put, the pentenyl chain 'looks' a lot like the pentyl chain, and is still nonreactive enough that it doesn't mess with the drug's binding or half life by too much.Can anyone explain where the difference between a pentyl-chain like usually found in cannabinoids and a pentene-yl chain like you can find in some of today's overly potent cannabinoids
why aren't they more widely used? Seems like a simple change in chemistry design. (For example there is a pentene-yl chain on the third cannbinoid above the bottom left one)
For example, exposure to acids like HCl can result in hydrohalogenations (turning the alkene into a saturated haloalkane)