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I Like to Draw Pictures of Random Molecules

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This approach may not be too promising. Further simplifying the molecule as shown gives the known alkaloid hordenine, which is toxic. See https://en.wikipedia.org/wiki/Hordenine

4-_2-_dimethylamino_ethyl_phenol.jpg
 
Take Strawberry ketone here: the compound that gives strawberry its smell and typical flavor. So-called weight loss compound (no evidence but ppl still buy into the hype google it).. anyway here is its structure:

4-%284-Hydroxyphenyl%29-2-butanone.png


Now add amino alfa to the ketone (very easy to do) you get this:

3-%28amino%29-4-%284-hydroxyphenyl%29butan-2-one.png



analog of the amino acid Tyrosine. Tyrosine is strictly required in all endogenous endorphins peptides for opioid activity. here is Tyrosine structure:
2-Amino-3-(4-hydroxyphenyl)propanoic%20acid.png


So this compound is same as Tyrosine but with the Tyrosine COOH replaced by COCH3. Now this molecule is potent pure mu agonist but also a NDRI so may be similar effect but more potent than desmethyltramadol + it might smell and taste like earthly fruity freshly cut strawberries.. Yummmy! %)! lots of similar ketones do but that's another story!

notice how it is now also a cathinone analog similar to methedrone or ethodrone or similar cathinones like methedrone here:
200px-4-Methoxymethcathinone.svg.png


but with the CO switched from the phenyl side to the alfa-alkyl side and the OMe replaced by OH.

Now if you were to replace the primary amine with a pyrrolidine, you now get MDPV type analogs with the CO moved to the alkyl side:

3-%28pyrrolidin-1-yl%29-4-%284-hydroxyphenyl%29butan-2-one.png


Will it smell and taste like strawberries?.. who knows?.. lemme know if anybody has come across one of these.. cheers
EDIT: inspired by PT
 
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Now add amino alfa to the ketone (very easy to do) you get this:

I don't agree. You will have to protect/deprotect that phenol group before you can add that amino function so it becomes a multi-step problem.
 
In the video currently circulating of the raid of a large and popular RC vendor, visible for a moment is a bag of lilolidine.

Never heard of it before & doesn't seem to have any use outside of being a precursor. Wonder what they were going to use it for.

vhmjhtM.png


just a fantasy. probably not even active. still wonder what the lilolidine was going to be used for.
 
JacksinPA said:
Now add amino alfa to the ketone (very easy to do) you get this:

I don't agree. You will have to protect/deprotect that phenol group before you can add that amino function so it becomes a multi-step problem.
Click to expand...
not really! depend how you go about doing it.. (here is one easy way with a phenolic ketone No need to protect the phenol !..but no synthesis talk on BL tho. (@mod: remove if inappropriate)
 
Interesting method but I don't see how you avoid brominating the terminal methyl group instead of your desired position. You might get an uneven mixture which might be hard to separate. End of synthesis talk.
 
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What is the function of Phenolic OH in morphine?
Hydrogen bond donator, or acceptor? I guess the former, since codeine is much weaker.
Or is there another binding mode of that OH?
 
Pomzazed said:
What is the function of Phenolic OH in morphine?
Hydrogen bond donator, or acceptor? I guess the former, since codeine is much weaker.
Or is there another binding mode of that OH?
Click to expand...

I would guess both. Try Googling that question.
 
Hey, send me a sample. I'll be your Guinea Pig. I still think raspberry ketone is the way to go, though.
 
ketamine long lost cousin: FRl15427
1-methyl-1-(3-methoxyphenyl)-1%2C2%2C3%2C4-tetrahydroisoquinoline%20.png

developed in france japan as safer ketamine analog (no bladder fuckup).. this is about 10x more potent than ketamine as NMDAr antagonist well tolerated substituted fully w/pcp in rodent.. doesnt look like any disso one can think of. MXE??


Or this one pretty interesting; a spiroindanyl isoindole .. this compound is about 1/3 PCP and fully substitute with tcp in rats.. (ref..).
7-methoxyspiro%5B1%2C2-dihydroindene-3%2C3'-1%2C2-dihydroisoindole%5D.png


I wonder if they wont be safer that ketamine MXE.etc I mean no muscarinic cholinergic of arycyclohexylamines since apparently this is what cause bladder fuckup of ketamines and the like. cheaper and way easier to make too.. safer antidepressant for sure..
 
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^ good eyes!!.. I didnt notice .indeed it looks like MK801 with ring open. it is ~10x less potent than mk801 which is good cause mk801 is insanely potent with unbelievably long half-life (days?? ) but yeah I think it would be REALLY COOL new disso rc the unsubstituted (i mean no MeO) is about 1.5xpcp tho..half-life is anybody guess but probably similar to pcpc..
 
Rather fanciful structures that combine both pharmacophores of morphine but avoids the fused ring system of that alkaloid. They appear to be difficult molecules to approach synthetically. The 6-methyl should have been drawn as being in a chiral center.

2_S_6_R_-3_6-dimethyl-1_2_3_4_5_6-hexahydro-2_6-methanobenzo_d_az.jpg


2_3_6-trimethyl-1_2_3_4_5_6-hexahydrobenzo_d_azocin-8-ol.jpg
 
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Known morphine analog

Interestingly, as far as the EPA is concerned, the racemic form of this aminoindene is a known compound (CAS 78950-87-5).

R_-2-_dipropylamino_-2_3-dihydro-1_H-inden-5-ol.jpg
 
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Another morphine analog preserving both pharmacophores

Further reducing the fanciful structures in order to obtain morphine analogs with simpler structures, I came up with this:

3a_S_8a_R_-1-methyl-1_2_3_3a_8_8a-hexahydroindeno_2_1-b_pyrrol-5-.jpg
 
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